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PREX1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [ Rousettus aegyptiacus (Egyptian rousette) ]

Gene ID: 107510319, updated on 30-Mar-2024

Summary

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Gene symbol
PREX1
Gene description
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
Locus tag
HJG63_015855
Gene type
protein coding
RefSeq status
MODEL
Organism
Rousettus aegyptiacus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Rousettinae; Rousettus
Orthologs
human mouse all
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Genomic context

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See PREX1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
40
Annotation release Status Assembly Chr Location
101 current mRouAeg1.p (GCF_014176215.1) Unplaced Scaffold NW_023416287.1 (8690426..8863132)
100 previous assembly Raegyp2.0 (GCF_001466805.2) Unplaced Scaffold NW_015494033.1 (492003..668367, complement)

NW_023416287.1Genomic Context describing neighboring genes Neighboring gene methylthioribulose-1-phosphate dehydratase-like Neighboring gene 5S ribosomal RNA Neighboring gene ARF guanine nucleotide exchange factor 2 Neighboring gene 5S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized LOC118609939 Neighboring gene nucleolin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rousettus aegyptiacus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRouAeg1.p

Genomic

  1. NW_023416287.1 Reference mRouAeg1.p

    Range
    8690426..8863132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016143709.2 → XP_015999195.2  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X2

    UniProtKB/TrEMBL
    A0A7J8DJY1
    Conserved Domains (6) summary
    smart00228
    Location:632 → 699
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00136
    Location:718 → 770
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd04440
    Location:503 → 595
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:241 → 393
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00621
    Location:50 → 235
    RhoGEF; RhoGEF domain
    cl02442
    Location:411 → 491
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

  2. XM_016143708.2 → XP_015999194.2  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1

    Conserved Domains (6) summary
    smart00228
    Location:632 → 699
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00136
    Location:718 → 770
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd04440
    Location:503 → 595
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:241 → 393
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00621
    Location:50 → 235
    RhoGEF; RhoGEF domain
    cl02442
    Location:411 → 491
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
Nucleotide Protein
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