U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [ Mus musculus (house mouse) ]

Gene ID: 277360, updated on 7-May-2024

Summary

Official Symbol
Prex1provided by MGI
Official Full Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1provided by MGI
Primary source
MGI:MGI:3040696
See related
Ensembl:ENSMUSG00000039621 AllianceGenome:MGI:3040696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Setd6; P-REX1; G630042G04
Summary
Predicted to enable phospholipid binding activity. Acts upstream of or within several processes, including neutrophil chemotaxis; positive regulation of GTPase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; nervous system; palatal shelf; skeleton; and testis. Used to study autism spectrum disorder. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 69.0), spleen adult (RPKM 46.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prex1 in Genome Data Viewer
Location:
2 H3; 2 87.09 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166408265..166555752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166566345..166713832, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30908 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 2_2197.1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166374636-166374823 Neighboring gene predicted gene, 29679 Neighboring gene STARR-positive B cell enhancer ABC_E4521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166455969-166456190 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166462419-166462620 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166488818-166489019 Neighboring gene STARR-positive B cell enhancer ABC_E1259 Neighboring gene predicted gene, 50596 Neighboring gene predicted gene, 46777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166571427-166571628 Neighboring gene predicted gene, 31117

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Names
SET domain containing 6
ptdIns(3,4,5)-dependent Rac exchanger 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177782.3NP_808450.2  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

    See identical proteins and their annotated locations for NP_808450.2

    Status: VALIDATED

    Source sequence(s)
    AK173168
    Consensus CDS
    CCDS38334.1
    UniProtKB/Swiss-Prot
    A2A5U1, Q69ZK0, Q6PFD4, Q8BN08
    UniProtKB/TrEMBL
    B2RXQ5, B9EKR4
    Related
    ENSMUSP00000037180.6, ENSMUST00000036719.12
    Conserved Domains (6) summary
    smart00228
    Location:630697
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00136
    Location:714768
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd00160
    Location:45233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04440
    Location:501593
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:239391
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl02442
    Location:409489
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    166408265..166555752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)