NUDC nuclear distribution C, dynein complex regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: NUDCprovided by HGNC
Official Full Name: nuclear distribution C, dynein complex regulatorprovided by HGNC
Primary source: HGNC:HGNC:8045
See related: Ensembl:ENSG00000090273 MIM:610325
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HNUDC; MNUDC; NPD011
Summary: This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
Expression: Ubiquitous expression in testis (RPKM 27.7), adrenal (RPKM 27.5) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 1p36.11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109.20191205	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (26900569..26946871)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (27248187..27273362)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High expression of NUDC is associated with prostate cancer.
Title: MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein.
the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells.
Title: MicroRNA-194 restrains the cell progression of non-small cell lung cancer by targeting human nuclear distribution protein C.
NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis.
Title: Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis.
NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression.
Title: NudC deacetylation regulates mitotic progression.
Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma.
Title: [Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma].
NudC may be involved in the regulation of LIS1 stability by its chaperone function.
Title: The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.
separate binding sites on the Mpl receptor for TPO and hNUDC identified
Title: Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC).
Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation.
Title: Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation.
hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways
Title: hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl).
hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation.
Title: Regulation of cell differentiation by hNUDC via a Mpl-dependent mechanism in NIH 3T3 cells.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with nuclear distribution gene C homolog (NUDC) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of nudC nuclear distribution protein (NUDC) in Jurkat cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2560 (e-PCR)
- UniSTS:37928

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-33625 (e-PCR)
- UniSTS:66209

RH69664 (e-PCR)
- UniSTS:64991

Homology

Homologs of the NUDC gene: The NUDC gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 294 organisms have orthologs with human gene NUDC
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cadherin binding	HDA more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
developmental process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
microtubule	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: nuclear migration protein nudC

Names: nuclear distribution C homolog; nuclear distribution gene C homolog; nuclear distribution protein C homolog; nudC nuclear distribution protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006600.4 → NP_006591.1 nuclear migration protein nudC

See identical proteins and their annotated locations for NP_006591.1

Status: REVIEWED

Source sequence(s)

AL356390, BC007280

Consensus CDS

CCDS292.1

UniProtKB/Swiss-Prot

Q9Y266

Related

ENSP00000319664.5, ENST00000321265.10

Conserved Domains (3) summary

cd06492
Location:172 → 258

p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...

pfam14050
Location:9 → 59

Nudc_N; N-terminal conserved domain of Nudc

pfam16273
Location:98 → 141

NuDC; Nuclear distribution C domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p13 Primary Assembly

Range

26900569..26946871

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024452486.1 → XP_024308254.1 nuclear migration protein nudC isoform X4

Conserved Domains (4) summary

cd06492
Location:176 → 262

p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...

pfam14050
Location:32 → 63

Nudc_N; N-terminal conserved domain of Nudc

pfam16273
Location:102 → 145

NuDC; Nuclear distribution C domain

cl21469
Location:52 → 97

HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
XM_017000094.1 → XP_016855583.1 nuclear migration protein nudC isoform X1
XM_017000095.2 → XP_016855584.1 nuclear migration protein nudC isoform X2
XM_011540530.1 → XP_011538832.1 nuclear migration protein nudC isoform X5

Conserved Domains (2) summary

cd06492
Location:123 → 209

p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...

pfam16273
Location:49 → 92

NuDC; Nuclear distribution C domain
XM_017000096.2 → XP_016855585.1 nuclear migration protein nudC isoform X3