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NUDC nuclear distribution C, dynein complex regulator [ Homo sapiens (human) ]

Gene ID: 10726, updated on 9-Dec-2018

Summary

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Official Symbol
NUDCprovided by HGNC
Official Full Name
nuclear distribution C, dynein complex regulatorprovided by HGNC
Primary source
HGNC:HGNC:8045
See related
Ensembl:ENSG00000090273 MIM:610325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNUDC; MNUDC; NPD011
Summary
This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in testis (RPKM 27.7), adrenal (RPKM 27.5) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See NUDC in Genome Data Viewer
Location:
1p36.11
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (26900569..26946871)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27248187..27273362)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 2 Neighboring gene G-patch domain containing 3 Neighboring gene nuclear receptor subfamily 0 group B member 2 Neighboring gene keratinocyte differentiation factor 1 Neighboring gene ribosomal protein L12 pseudogene 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NudC deacetylation regulates mitotic progression. Chuang C, et al. PLoS One, 2013. PMID 24069238, Free PMC Article
  2. [Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma]. Chen Y, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2011 Jan. PMID 21473139
  3. Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein. Lin SH, et al. Oncogene, 2004 Apr 1. PMID 14676831
  4. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Miller BA, et al. Exp Hematol, 1999 Apr. PMID 10210332
  5. MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein. Kong Q, et al. Oncol Rep, 2017 Feb. PMID 27959429

See all (82) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. High expression of NUDC is associated with prostate cancer.
    Title: MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein.
  2. the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells.
    Title: MicroRNA-194 restrains the cell progression of non-small cell lung cancer by targeting human nuclear distribution protein C.
  3. NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis.
    Title: Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis.
  4. NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression.
    Title: NudC deacetylation regulates mitotic progression.
  5. Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma.
    Title: [Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma].
  6. NudC may be involved in the regulation of LIS1 stability by its chaperone function.
    Title: The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.
  7. separate binding sites on the Mpl receptor for TPO and hNUDC identified
    Title: Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC).
  8. Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation.
    Title: Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation.
  9. hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways
    Title: hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl).
  10. hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation.
    Title: Regulation of cell differentiation by hNUDC via a Mpl-dependent mechanism in NIH 3T3 cells.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with nuclear distribution gene C homolog (NUDC) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat HIV-1 Tat upregulates the expression of nudC nuclear distribution protein (NUDC) in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
    Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
    Lissencephaly gene (LIS1) in neuronal migration and development
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Mitotic Telophase/Cytokinesis, organism-specific biosystem (from REACTOME)
    Mitotic Telophase/Cytokinesis, organism-specific biosystemIn this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around th...
  • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    PLK1 signaling events, organism-specific biosystem
    PLK1 signaling events
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
  
cell division IEA
Inferred from Electronic Annotation
more info
  
cell proliferation TAS
Traceable Author Statement
more info
 PubMed 
developmental process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
 PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytosol IDA
Inferred from Direct Assay
more info
  
cytosol TAS
Traceable Author Statement
more info
  
microtubule IEA
Inferred from Electronic Annotation
more info
  
nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
nuclear migration protein nudC
Names
nuclear distribution C homolog
nuclear distribution gene C homolog
nuclear distribution protein C homolog
nudC nuclear distribution protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006600.4 → NP_006591.1  nuclear migration protein nudC

    See identical proteins and their annotated locations for NP_006591.1

    Status: REVIEWED

    Source sequence(s)
    AL356390, BC007280
    Consensus CDS
    CCDS292.1
    UniProtKB/Swiss-Prot
    Q9Y266
    Related
    ENSP00000319664.5, ENST00000321265.9
    Conserved Domains (3) summary
    cd06492
    Location:172 → 258
    p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
    pfam14050
    Location:9 → 59
    Nudc_N; N-terminal conserved domain of Nudc
    pfam16273
    Location:98 → 141
    NuDC; Nuclear distribution C domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    26900569..26946871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452486.1 → XP_024308254.1  nuclear migration protein nudC isoform X4

    Conserved Domains (4) summary
    cd06492
    Location:176 → 262
    p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
    pfam14050
    Location:32 → 63
    Nudc_N; N-terminal conserved domain of Nudc
    pfam16273
    Location:102 → 145
    NuDC; Nuclear distribution C domain
    cl21469
    Location:52 → 97
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  2. XM_017000094.1 → XP_016855583.1  nuclear migration protein nudC isoform X1

  3. XM_017000095.2 → XP_016855584.1  nuclear migration protein nudC isoform X2

  4. XM_011540530.1 → XP_011538832.1  nuclear migration protein nudC isoform X5

    Conserved Domains (2) summary
    cd06492
    Location:123 → 209
    p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
    pfam16273
    Location:49 → 92
    NuDC; Nuclear distribution C domain

  5. XM_017000096.2 → XP_016855585.1  nuclear migration protein nudC isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y266.1 GenPept UniProtKB/Swiss-Prot:Q9Y266

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