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GNB5 G protein subunit beta 5 [ Homo sapiens (human) ]

Gene ID: 10681, updated on 14-Oct-2021

Summary

Official Symbol
GNB5provided by HGNC
Official Full Name
G protein subunit beta 5provided by HGNC
Primary source
HGNC:HGNC:4401
See related
Ensembl:ENSG00000069966 MIM:604447
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GB5; HG2E; IDDCA; LADCI; gbeta5
Summary
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 9.7), kidney (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

See GNB5 in Genome Data Viewer
Location:
15q21.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (52115100..52191392, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52407297..52483589, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268150 Neighboring gene ribosomal protein S13 pseudogene 8 Neighboring gene BCL2 like 10 Neighboring gene competing endogenous lncRNA 1 for miR-4707-5p and miR-4767 Neighboring gene myosin VC Neighboring gene uncharacterized LOC105370820 Neighboring gene microRNA 1266

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37457, FLJ43714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein gamma-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dark adaptation IEA
Inferred from Electronic Annotation
more info
 
involved_in dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in light adaption IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of GTPase activator complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit beta-5
Names
G protein, beta subunit 5L
guanine nucleotide binding protein (G protein), beta 5
guanine nucleotide-binding protein, beta subunit 5L
heterotrimeric guanine nucleotide-binding protein 2E
transducin beta chain 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052868.1 RefSeqGene

    Range
    5001..75443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379343.1NP_001366272.1  guanine nucleotide-binding protein subunit beta-5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010674, AC023906
    Conserved Domains (2) summary
    cd00200
    Location:4301
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1451
    7WD40; WD40 repeat [structural motif]
  2. NM_006578.4NP_006569.1  guanine nucleotide-binding protein subunit beta-5 isoform a

    See identical proteins and their annotated locations for NP_006569.1

    Status: REVIEWED

    Source sequence(s)
    AC023906, AF017656, BC013997
    Consensus CDS
    CCDS45261.1
    UniProtKB/Swiss-Prot
    O14775
    UniProtKB/TrEMBL
    A0A024R5R9
    Related
    ENSP00000351635.7, ENST00000358784.11
    Conserved Domains (2) summary
    cd00200
    Location:56353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:66103
    7WD40; WD40 repeat [structural motif]
  3. NM_016194.4NP_057278.2  guanine nucleotide-binding protein subunit beta-5 isoform b

    See identical proteins and their annotated locations for NP_057278.2

    Status: REVIEWED

    Source sequence(s)
    AC010674, AC023906, AW967075, BC013997
    Consensus CDS
    CCDS10149.1
    UniProtKB/Swiss-Prot
    O14775
    UniProtKB/TrEMBL
    A0A024R5V3
    Related
    ENSP00000261837.7, ENST00000261837.12
    Conserved Domains (2) summary
    cd00200
    Location:98395
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:108145
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    52115100..52191392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521162.3XP_011519464.1  guanine nucleotide-binding protein subunit beta-5 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:54352
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:56353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:66103
    7WD40; WD40 repeat [structural motif]
  2. XM_017021867.2XP_016877356.1  guanine nucleotide-binding protein subunit beta-5 isoform X3

    Conserved Domains (2) summary
    cd00200
    Location:9212
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1551
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_001751060.2 RNA Sequence

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