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Gnb5 guanine nucleotide binding protein (G protein), beta 5 [ Mus musculus (house mouse) ]

Gene ID: 14697, updated on 18-Sep-2024

Summary

Official Symbol
Gnb5provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 5provided by MGI
Primary source
MGI:MGI:101848
See related
Ensembl:ENSMUSG00000032192 AllianceGenome:MGI:101848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GBS; flr; Hg2e; Gbeta5
Summary
Predicted to enable several functions, including G-protein gamma-subunit binding activity; GTPase activating protein binding activity; and chaperone binding activity. Predicted to contribute to GTPase activator activity. Acts upstream of or within G protein-coupled receptor signaling pathway; dark adaptation; and light adaption. Located in several cellular components, including nucleus; photoreceptor inner segment; and photoreceptor outer segment. Is active in presynapse. Is expressed in several structures, including brain; eye; genitourinary system; liver; and lung. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Orthologous to human GNB5 (G protein subunit beta 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 36.1), frontal lobe adult (RPKM 31.3) and 19 other tissues See more
Orthologs
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Genomic context

See Gnb5 in Genome Data Viewer
Location:
9 D; 9 42.3 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75213570..75253205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75306288..75345923)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33750 Neighboring gene myosin VC Neighboring gene predicted gene, 53503 Neighboring gene STARR-seq mESC enhancer starr_24658 Neighboring gene predicted gene, 19531 Neighboring gene Bcl2-like 10 Neighboring gene STARR-positive B cell enhancer ABC_E11750 Neighboring gene zygote arrest 1-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein gamma-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein gamma-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell tip IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in myelin sheath HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit beta-5
Names
flail
flailer
guanine nucleotide binding protein, beta 5
heterotrimeric guanine nucleotide-binding protein 2e
hug
transducin beta chain 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010313.2NP_034443.1  guanine nucleotide-binding protein subunit beta-5 isoform 1

    See identical proteins and their annotated locations for NP_034443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1; also known as Long, Beta-5L, Gbeta5L) encodes the longer isoform (1).
    Source sequence(s)
    AI323394, BX513135, BY607717, CK621143, U69145
    Consensus CDS
    CCDS40692.1
    UniProtKB/Swiss-Prot
    O35354, P54314, P62881, Q91WB3
    UniProtKB/TrEMBL
    Q3V331
    Related
    ENSMUSP00000149938.2, ENSMUST00000213990.2
    Conserved Domains (2) summary
    cd00200
    Location:98395
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:108145
    7WD40; WD40 repeat [structural motif]
  2. NM_138719.5NP_619733.1  guanine nucleotide-binding protein subunit beta-5 isoform 2

    See identical proteins and their annotated locations for NP_619733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2; also known as Gbeta5S) differs in the 5' UTR compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC133947
    Consensus CDS
    CCDS90626.1
    UniProtKB/TrEMBL
    Q3UG14, Q3V331
    Related
    ENSMUSP00000150492.2, ENSMUST00000215875.2
    Conserved Domains (2) summary
    cd00200
    Location:56353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:66103
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_073186.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC133947

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75213570..75253205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004935317.1 RNA Sequence