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CHERP calcium homeostasis endoplasmic reticulum protein [ Homo sapiens (human) ]

Gene ID: 10523, updated on 18-Aug-2020

Summary

Official Symbol
CHERPprovided by HGNC
Official Full Name
calcium homeostasis endoplasmic reticulum proteinprovided by HGNC
Primary source
HGNC:HGNC:16930
See related
Ensembl:ENSG00000085872 MIM:618539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRA1; DAN16; SCAF6
Expression
Ubiquitous expression in testis (RPKM 13.3), spleen (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See CHERP in Genome Data Viewer
Location:
19p13.11
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (16517894..16542437, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16628700..16653341, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor pathway substrate 15 like 1 Neighboring gene ribosomal protein S2 pseudogene 51 Neighboring gene calreticulin 3 Neighboring gene chromosome 19 open reading frame 44 Neighboring gene RNA, 7SL, cytoplasmic 146, pseudogene Neighboring gene solute carrier family 35 member E1 Neighboring gene uncharacterized LOC105372295 Neighboring gene mediator complex subunit 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
calcium homeostasis endoplasmic reticulum protein
Names
ERPROT 213-21
ERPROT213-21
SR-related CTD associated factor 6
protein with polyglutamine repeat

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006387.6NP_006378.3  calcium homeostasis endoplasmic reticulum protein

    See identical proteins and their annotated locations for NP_006378.3

    Status: VALIDATED

    Source sequence(s)
    AA782418, BC021294, U94836
    Consensus CDS
    CCDS42518.1
    UniProtKB/Swiss-Prot
    Q8IWX8
    Related
    ENSP00000439856.2, ENST00000546361.7
    Conserved Domains (3) summary
    smart00443
    Location:839889
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:1365
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:212271
    CTD_bind; RNA polymerase II-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    16517894..16542437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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