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MED26 mediator complex subunit 26 [ Homo sapiens (human) ]

Gene ID: 9441, updated on 25-Nov-2021

Summary

Official Symbol
MED26provided by HGNC
Official Full Name
mediator complex subunit 26provided by HGNC
Primary source
HGNC:HGNC:2376
See related
Ensembl:ENSG00000105085 MIM:605043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRSP7; CRSP70
Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 18.2), bone marrow (RPKM 6.2) and 23 other tissues See more
Orthologs
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Genomic context

See MED26 in Genome Data Viewer
Location:
19p13.11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (16574919..16628204, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16685730..16739015, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene RNA, 7SL, cytoplasmic 146, pseudogene Neighboring gene solute carrier family 35 member E1 Neighboring gene uncharacterized LOC105372295 Neighboring gene uncharacterized LOC105372296 Neighboring gene small integral membrane protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 26 (MED26) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED26 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 26
Names
ARC70
CRSP complex subunit 7
activator-recruited cofactor 70 kDa component
cofactor required for Sp1 transcriptional activation subunit 7
cofactor required for Sp1 transcriptional activation, subunit 7 (70kD)
cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa
transcriptional coactivator CRSP70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004831.5NP_004822.2  mediator of RNA polymerase II transcription subunit 26

    See identical proteins and their annotated locations for NP_004822.2

    Status: VALIDATED

    Source sequence(s)
    AC008764, AC024075, AF104253, AK128435
    Consensus CDS
    CCDS12347.1
    UniProtKB/Swiss-Prot
    O95402
    Related
    ENSP00000263390.3, ENST00000263390.8
    Conserved Domains (3) summary
    smart00509
    Location:1286
    TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
    pfam15693
    Location:419598
    Med26_C; Mediator complex subunit 26 C-terminal
    pfam15694
    Location:177417
    Med26_M; Mediator complex subunit 26 middle domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    16574919..16628204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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