U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cherp calcium homeostasis endoplasmic reticulum protein [ Mus musculus (house mouse) ]

Gene ID: 27967, updated on 30-Apr-2024

Summary

Official Symbol
Cherpprovided by MGI
Official Full Name
calcium homeostasis endoplasmic reticulum proteinprovided by MGI
Primary source
MGI:MGI:106417
See related
Ensembl:ENSMUSG00000052488 AllianceGenome:MGI:106417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAN16; Scaf6; D8Wsu96e; 5730408I11Rik
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in perinuclear region of cytoplasm. Is expressed in embryo and extraembryonic component. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 40.1), limb E14.5 (RPKM 31.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cherp in Genome Data Viewer
Location:
8 B3.3; 8 35.08 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73214327..73229077, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72460483..72475233, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calreticulin 3 Neighboring gene STARR-positive B cell enhancer ABC_E6662 Neighboring gene microRNA 7068 Neighboring gene solute carrier family 35, member E1 Neighboring gene STARR-positive B cell enhancer ABC_E2267 Neighboring gene uncharacterized LOC102639683 Neighboring gene mediator complex subunit 26

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium homeostasis endoplasmic reticulum protein
Names
SR-related CTD associated factor 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359024.1NP_001345953.1  calcium homeostasis endoplasmic reticulum protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113182
    Consensus CDS
    CCDS90417.1
    UniProtKB/Swiss-Prot
    Q8CGZ0, Q8K291, Q8VCD2
    UniProtKB/TrEMBL
    G5E8I8
    Related
    ENSMUSP00000078469.6, ENSMUST00000079510.6
    Conserved Domains (5) summary
    smart00443
    Location:861911
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:1365
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:211284
    CTD_bind; RNA polymerase II-binding domain
    cl25764
    Location:528666
    PAT1; Topoisomerase II-associated protein PAT1
    cl27975
    Location:393702
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  2. NM_138585.3NP_613051.3  calcium homeostasis endoplasmic reticulum protein isoform 1

    See identical proteins and their annotated locations for NP_613051.3

    Status: VALIDATED

    Source sequence(s)
    AF536541, AK049765, BY061354
    Consensus CDS
    CCDS40389.1
    UniProtKB/Swiss-Prot
    Q8CGZ0, Q8K291, Q8VCD2
    UniProtKB/TrEMBL
    A0A1D5RL92
    Related
    ENSMUSP00000148273.2, ENSMUST00000212991.2
    Conserved Domains (3) summary
    smart00443
    Location:850900
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:1365
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:212271
    CTD_bind; RNA polymerase II-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73214327..73229077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)