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Cherp calcium homeostasis endoplasmic reticulum protein [ Mus musculus (house mouse) ]

Gene ID: 27967, updated on 2-Nov-2024

Summary

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Official Symbol
Cherpprovided by MGI
Official Full Name
calcium homeostasis endoplasmic reticulum proteinprovided by MGI
Primary source
MGI:MGI:106417
See related
Ensembl:ENSMUSG00000052488 AllianceGenome:MGI:106417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAN16; Scaf6; D8Wsu96e; 5730408I11Rik
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in intracellular calcium ion homeostasis; positive regulation of calcineurin-NFAT signaling cascade; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in perinuclear region of cytoplasm. Is expressed in embryo and extraembryonic component. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 40.1), limb E14.5 (RPKM 31.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cherp in Genome Data Viewer
Location:
8 B3.3; 8 35.08 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73214327..73229077, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72460483..72475233, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calreticulin 3 Neighboring gene STARR-positive B cell enhancer ABC_E6662 Neighboring gene microRNA 7068 Neighboring gene solute carrier family 35, member E1 Neighboring gene STARR-positive B cell enhancer ABC_E2267 Neighboring gene uncharacterized LOC102639683 Neighboring gene mediator complex subunit 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. Contos JJ, et al. Genomics, 2000 Mar 1. PMID 10729222
  2. Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins. Crisci A, et al. Nucleic Acids Res, 2015 Dec 2. PMID 26420826, Free PMC Article
  3. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang T, et al. Cell, 2017 Feb 23. PMID 28162770, Free PMC Article
  4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium homeostasis endoplasmic reticulum protein
Names
SR-related CTD associated factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359024.1 → NP_001345953.1  calcium homeostasis endoplasmic reticulum protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113182
    Consensus CDS
    CCDS90417.1
    UniProtKB/Swiss-Prot
    Q8CGZ0, Q8K291, Q8VCD2
    UniProtKB/TrEMBL
    G5E8I8
    Related
    ENSMUSP00000078469.6, ENSMUST00000079510.6
    Conserved Domains (5) summary
    smart00443
    Location:861 → 911
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:13 → 65
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:211 → 284
    CTD_bind; RNA polymerase II-binding domain
    cl25764
    Location:528 → 666
    PAT1; Topoisomerase II-associated protein PAT1
    cl27975
    Location:393 → 702
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

  2. NM_138585.3 → NP_613051.3  calcium homeostasis endoplasmic reticulum protein isoform 1

    See identical proteins and their annotated locations for NP_613051.3

    Status: VALIDATED

    Source sequence(s)
    AF536541, AK049765, BY061354
    Consensus CDS
    CCDS40389.1
    UniProtKB/Swiss-Prot
    Q8CGZ0, Q8K291, Q8VCD2
    UniProtKB/TrEMBL
    A0A1D5RL92
    Related
    ENSMUSP00000148273.2, ENSMUST00000212991.2
    Conserved Domains (3) summary
    smart00443
    Location:850 → 900
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:13 → 65
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:212 → 271
    CTD_bind; RNA polymerase II-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73214327..73229077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGZ0.1 GenPept UniProtKB/Swiss-Prot:Q8CGZ0

Gene LinkOut

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