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Zfp692 zinc finger protein 692 [ Mus musculus (house mouse) ]

Gene ID: 103836, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp692provided by MGI
Official Full Name
zinc finger protein 692provided by MGI
Primary source
MGI:MGI:2144276
See related
Ensembl:ENSMUSG00000037243 AllianceGenome:MGI:2144276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf692; Zfp692-ps
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in kinetochore. Is expressed in several structures, including 1st branchial arch; limb; male reproductive system; maxillary process; and urinary system. Orthologous to human ZNF692 (zinc finger protein 692). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 26.7), CNS E18 (RPKM 23.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp692 in Genome Data Viewer
Location:
11 B1.3; 11 36.19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58197883..58205971)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58307057..58315145)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39827 Neighboring gene nuclear encoded tRNA glutamic acid 10 (anticodon CTC) Neighboring gene STARR-positive B cell enhancer ABC_E2989 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAA) Neighboring gene zinc finger protein 672 Neighboring gene STARR-positive B cell enhancer ABC_E3953 Neighboring gene SH3 binding domain protein 5 like Neighboring gene predicted gene, 33660

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo. Shirai T, et al. Biochem Biophys Res Commun, 2011 Oct 22. PMID 21910974
  2. Retinal transcriptome of neonatal mice after optic nerve injury. Yao SQ, et al. PLoS One, 2023. PMID 37252932, Free PMC Article
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AREBP is a key modulator of hepatic glucose production regulated by AMPK in vivo.
    Title: AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 692
Names
AICAR responsive element binding protein
zinc finger protein 692, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040686.1 → NP_001035776.1  zinc finger protein 692

    See identical proteins and their annotated locations for NP_001035776.1

    Status: VALIDATED

    Source sequence(s)
    AL845463
    Consensus CDS
    CCDS36162.1
    UniProtKB/Swiss-Prot
    Q3U381
    UniProtKB/TrEMBL
    B2RX02
    Related
    ENSMUSP00000126674.2, ENSMUST00000153510.9
    Conserved Domains (4) summary
    COG5048
    Location:383 → 436
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:360 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:402 → 427
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:328 → 406
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_182996.3 → NP_892041.2  zinc finger protein 692

    See identical proteins and their annotated locations for NP_892041.2

    Status: VALIDATED

    Source sequence(s)
    AL845463
    Consensus CDS
    CCDS36162.1
    UniProtKB/Swiss-Prot
    Q3U381
    UniProtKB/TrEMBL
    B2RX02
    Related
    ENSMUSP00000131896.2, ENSMUST00000049353.9
    Conserved Domains (4) summary
    COG5048
    Location:383 → 436
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:360 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:402 → 427
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:328 → 406
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58197883..58205971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156191.1 → XP_036012084.1  zinc finger protein 692 isoform X1

    Conserved Domains (3) summary
    COG5236
    Location:229 → 344
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:200 → 278
    zf-C2H2_8; C2H2-type zinc ribbon

  2. XM_036156192.1 → XP_036012085.1  zinc finger protein 692 isoform X1

    Conserved Domains (3) summary
    COG5236
    Location:229 → 344
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:200 → 278
    zf-C2H2_8; C2H2-type zinc ribbon

  3. XM_006531919.4 → XP_006531982.1  zinc finger protein 692 isoform X1

    See identical proteins and their annotated locations for XP_006531982.1

    Conserved Domains (3) summary
    COG5236
    Location:229 → 344
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:200 → 278
    zf-C2H2_8; C2H2-type zinc ribbon

  4. XM_036156193.1 → XP_036012086.1  zinc finger protein 692 isoform X1

    Conserved Domains (3) summary
    COG5236
    Location:229 → 344
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:200 → 278
    zf-C2H2_8; C2H2-type zinc ribbon

  5. XM_006531920.2 → XP_006531983.1  zinc finger protein 692 isoform X1

    See identical proteins and their annotated locations for XP_006531983.1

    Conserved Domains (3) summary
    COG5236
    Location:229 → 344
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:200 → 278
    zf-C2H2_8; C2H2-type zinc ribbon
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U381.1 GenPept UniProtKB/Swiss-Prot:Q3U381

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