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ZNF692 zinc finger protein 692 [ Homo sapiens (human) ]

Gene ID: 55657, updated on 1-Aug-2020

Summary

Official Symbol
ZNF692provided by HGNC
Official Full Name
zinc finger protein 692provided by HGNC
Primary source
HGNC:HGNC:26049
See related
Ensembl:ENSG00000171163 MIM:617758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AREBP; Zfp692
Expression
Ubiquitous expression in testis (RPKM 9.4), prostate (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF692 in Genome Data Viewer
Location:
1q44
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (248850004..248860761, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (249144203..249153315, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 3124 Neighboring gene zinc finger protein 672 Neighboring gene tRNA-Leu (anticodon CAA) 4-1 Neighboring gene tRNA-Glu (anticodon CTC) 2-1 Neighboring gene piggyBac transposable element derived 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20531

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 692
Names
AICAR responsive element binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136036.3NP_001129508.1  zinc finger protein 692 isoform 1

    See identical proteins and their annotated locations for NP_001129508.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK302187, AL672291, DA147512, DB520788, H07076
    Consensus CDS
    CCDS44348.1
    UniProtKB/Swiss-Prot
    Q9BU19
    Related
    ENSP00000391200.1, ENST00000451251.5
    Conserved Domains (4) summary
    COG5048
    Location:389490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:366388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:394416
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:408433
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001193328.2NP_001180257.1  zinc finger protein 692 isoform 3

    See identical proteins and their annotated locations for NP_001180257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different first exon, which results in the use of a downstream start codon, and lacks an alternate exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK225535, AK302187, H07076
    Consensus CDS
    CCDS53487.1
    UniProtKB/Swiss-Prot
    Q9BU19
    Related
    ENSP00000355427.3, ENST00000366471.7
    Conserved Domains (3) summary
    sd00017
    Location:316338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:344366
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:358383
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001350072.2NP_001337001.1  zinc finger protein 692 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a different first exon, which results in the use of a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus and lacks an internal aa when it is compared to isoform 1.
    Source sequence(s)
    BC002948, DA319079
    Conserved Domains (4) summary
    COG5189
    Location:289407
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:357484
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:360382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:208332
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. NM_001350073.2NP_001337002.1  zinc finger protein 692 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains a different first exon, and uses alternate splice sites at another exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL672291, BC002948, DA319079, DA765600
    Conserved Domains (4) summary
    COG5189
    Location:86204
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:154281
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:157179
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl25580
    Location:4121
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  5. NM_017865.4NP_060335.2  zinc finger protein 692 isoform 2

    See identical proteins and their annotated locations for NP_060335.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different first exon, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    BC002948, DA319079
    Consensus CDS
    CCDS31127.1
    UniProtKB/Swiss-Prot
    Q9BU19
    Related
    ENSP00000305483.4, ENST00000306601.8
    Conserved Domains (4) summary
    COG5189
    Location:290408
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:358485
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:361383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl25580
    Location:208325
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    248850004..248860761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544223.2XP_011542525.1  zinc finger protein 692 isoform X7

    Conserved Domains (4) summary
    COG5048
    Location:490591
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:465489
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:509534
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011544221.2XP_011542523.2  zinc finger protein 692 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:156178
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:198223
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:124202
    zf-C2H2_8; C2H2-type zinc ribbon
    cl25580
    Location:4120
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  3. XM_017001699.2XP_016857188.2  zinc finger protein 692 isoform X5

    Related
    ENSP00000431582.1, ENST00000476503.5
    Conserved Domains (3) summary
    COG5189
    Location:62178
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:128255
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:131153
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011544220.2XP_011542522.2  zinc finger protein 692 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:86204
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:154281
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:157179
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl25580
    Location:4121
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  5. XM_017001698.1XP_016857187.1  zinc finger protein 692 isoform X4

    Conserved Domains (4) summary
    COG5189
    Location:289407
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:357484
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:360382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:208332
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  6. XM_017001700.1XP_016857189.1  zinc finger protein 692 isoform X6

  7. XM_011544222.1XP_011542524.1  zinc finger protein 692 isoform X3

    See identical proteins and their annotated locations for XP_011542524.1

    UniProtKB/Swiss-Prot
    Q9BU19
    Conserved Domains (4) summary
    COG5189
    Location:290408
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:358485
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:361383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl25580
    Location:208325
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  8. XM_017001705.1XP_016857194.1  zinc finger protein 692 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:86204
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:154281
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:157179
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl25580
    Location:4121
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  9. XM_017001702.2XP_016857191.1  zinc finger protein 692 isoform X6

  10. XM_017001704.1XP_016857193.1  zinc finger protein 692 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:86204
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:154281
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:157179
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl25580
    Location:4121
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  11. XM_011544227.1XP_011542529.1  zinc finger protein 692 isoform X8

    See identical proteins and their annotated locations for XP_011542529.1

    Conserved Domains (4) summary
    COG5048
    Location:357458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:362384
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:376401
    zf-H2C2_2; Zinc-finger double domain
  12. XM_024448274.1XP_024304042.1  zinc finger protein 692 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:86204
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:154281
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:157179
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl25580
    Location:4121
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

RNA

  1. XR_001737293.2 RNA Sequence

    Related
    ENST00000412341.6
  2. XR_949147.3 RNA Sequence

  3. XR_949146.3 RNA Sequence

  4. XR_002957066.1 RNA Sequence

  5. XR_001737294.2 RNA Sequence

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