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KLF2 Kruppel like factor 2 [ Homo sapiens (human) ]

Gene ID: 10365, updated on 12-Jul-2020

Summary

Official Symbol
KLF2provided by HGNC
Official Full Name
Kruppel like factor 2provided by HGNC
Primary source
HGNC:HGNC:6347
See related
Ensembl:ENSG00000127528 MIM:602016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LKLF
Summary
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
Expression
Broad expression in fat (RPKM 40.2), ovary (RPKM 23.1) and 19 other tissues See more
Orthologs

Genomic context

See KLF2 in Genome Data Viewer
Location:
19p13.11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (16324826..16328685)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16435651..16438345)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 32 member A Neighboring gene adaptor related protein complex 1 subunit mu 1 Neighboring gene epidermal growth factor receptor pathway substrate 15 like 1 Neighboring gene ribosomal protein S2 pseudogene 51 Neighboring gene calreticulin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Kruppel-like factor 2 (KLF2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of Kruppel-like factor 2 (KLF2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to cycloheximide IEA
Inferred from Electronic Annotation
more info
 
cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cellular response to laminar fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
cellular stress response to acid chemical IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression, epigenetic IEA
Inferred from Electronic Annotation
more info
 
type I pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 2
Names
Kruppel-like factor 2 (lung)
Kruppel-like factor LKLF
lung Kruppel-like factor
lung Kruppel-like zinc finger transcription factor
lung krueppel-like factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016270.4NP_057354.1  Krueppel-like factor 2

    See identical proteins and their annotated locations for NP_057354.1

    Status: REVIEWED

    Source sequence(s)
    AC020917
    Consensus CDS
    CCDS12343.1
    UniProtKB/Swiss-Prot
    Q9Y5W3
    Related
    ENSP00000248071.4, ENST00000248071.5
    Conserved Domains (4) summary
    COG5048
    Location:267350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:272296
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:318343
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    16324826..16328685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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