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KLF2 KLF transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 10365, updated on 4-Feb-2024

Summary

Official Symbol
KLF2provided by HGNC
Official Full Name
KLF transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:6347
See related
Ensembl:ENSG00000127528 MIM:602016; AllianceGenome:HGNC:6347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LKLF
Summary
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
Expression
Broad expression in fat (RPKM 40.2), ovary (RPKM 23.1) and 19 other tissues See more
Orthologs
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Genomic context

See KLF2 in Genome Data Viewer
Location:
19p13.11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (16324826..16328685)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (16459702..16463562)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16435637..16439496)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10292 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:16315239-16315388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16334661-16335161 Neighboring gene adaptor related protein complex 1 subunit mu 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16362883-16363384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16363385-16363884 Neighboring gene KLF2-I enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14219 Neighboring gene MPRA-validated peak3390 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10293 Neighboring gene KLF2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14221 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16435432-16436204 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16436205-16436975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14227 Neighboring gene epidermal growth factor receptor pathway substrate 15 like 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16486555-16487056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16494079-16494580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16528701-16529304 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16531117-16531720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16531721-16532324 Neighboring gene ribosomal protein S2 pseudogene 51 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16551872-16552372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16552373-16552873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14232 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:16555578-16556777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16564379-16564879 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16565415-16565914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16567358-16568116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16572441-16573108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16573109-16573776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16575487-16576411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16581959-16582870 Neighboring gene Sharpr-MPRA regulatory region 3003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16606242-16606742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16606743-16607243 Neighboring gene calreticulin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Kruppel-like factor 2 (KLF2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of Kruppel-like factor 2 (KLF2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cycloheximide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to laminar fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular stress response to acid chemical IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epigenetic regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in type I pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Krueppel-like factor 2
Names
Kruppel like factor 2
Kruppel-like factor 2 (lung)
Kruppel-like factor LKLF
lung Kruppel-like factor
lung Kruppel-like zinc finger transcription factor
lung krueppel-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016270.4NP_057354.1  Krueppel-like factor 2

    See identical proteins and their annotated locations for NP_057354.1

    Status: REVIEWED

    Source sequence(s)
    AC020917
    Consensus CDS
    CCDS12343.1
    UniProtKB/Swiss-Prot
    Q6IPC4, Q9UJS5, Q9UKR6, Q9Y5W3
    Related
    ENSP00000248071.5, ENST00000248071.6
    Conserved Domains (4) summary
    COG5048
    Location:267350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:272296
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:318343
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    16324826..16328685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    16459702..16463562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_006075.1: Suppressed sequence

    Description
    NM_006075.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  2. NM_016198.1: Suppressed sequence

    Description
    NM_016198.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.