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CDK5 cyclin dependent kinase 5 [ Homo sapiens (human) ]

Gene ID: 1020, updated on 9-Feb-2020

Summary

Official Symbol
CDK5provided by HGNC
Official Full Name
cyclin dependent kinase 5provided by HGNC
Primary source
HGNC:HGNC:1774
See related
Ensembl:ENSG00000164885 MIM:123831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIS7; PSSALRE
Summary
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in brain (RPKM 18.5), adrenal (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See CDK5 in Genome Data Viewer
Location:
7q36.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (151053815..151057897, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150750899..150755052, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 8 Neighboring gene acid sensing ion channel subunit 3 Neighboring gene solute carrier family 4 member 2 Neighboring gene Fas activated serine/threonine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with CDK5 PubMed
Tat tat HIV-1 Tat hyperactivates CDK5 by interfering with it's nucleo-cytoplasmic translocation in neuronal cells PubMed
tat HIV-1 Tat increases levels of phosphorylated Cdk5 in human neuronal cells PubMed
tat Neural cells expressing Tat reduces the phosphorylation level of neurofilaments by p35/Cdk5 PubMed
tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
tat HIV-1 Tat downregulates the expression of p35, a neuron-specific activator of cdk5, and also binds to Puralpha, which associates with cdk5, leading to deregulation of neuronal differentiation and survival PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ErbB-2 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ErbB-3 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
acetylcholine receptor activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT microtubule binding TAS
Traceable Author Statement
more info
PubMed 
p53 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Schwann cell development IEA
Inferred from Electronic Annotation
more info
 
axon extension TAS
Traceable Author Statement
more info
PubMed 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
calcium ion import IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
 
central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex formation IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
histone phosphorylation IEA
Inferred from Electronic Annotation
more info
 
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron apoptotic process TAS
Traceable Author Statement
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
neuron migration TAS
Traceable Author Statement
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection development TAS
Traceable Author Statement
more info
PubMed 
nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of actin cytoskeleton reorganization TAS
Traceable Author Statement
more info
PubMed 
positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
receptor clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of macroautophagy TAS
Traceable Author Statement
more info
PubMed 
regulation of neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic vesicle recycling NAS
Non-traceable Author Statement
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
serine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
synapse assembly TAS
Traceable Author Statement
more info
PubMed 
synapse pruning IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle endocytosis TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
protein kinase 5 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclin-dependent-like kinase 5
Names
TPKII catalytic subunit
cell division protein kinase 5
epididymis secretory sperm binding protein
protein kinase CDK5 splicing
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
NP_001157882.1
NP_004926.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042167.1 RefSeqGene

    Range
    5069..9151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164410.3NP_001157882.1  cyclin-dependent-like kinase 5 isoform 2

    See identical proteins and their annotated locations for NP_001157882.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as CDK5-SV, omits an in-frame coding exon compared to variant 1 resulting in a shorter predicted protein (isoform 2). Expression of this transcript was described by Li et al. (2009; PubMed ID 19693690).
    Source sequence(s)
    AK026533, CA429180, DB487008, DQ411039
    Consensus CDS
    CCDS55184.1
    UniProtKB/Swiss-Prot
    Q00535
    UniProtKB/TrEMBL
    A0A0S2Z355
    Related
    ENSP00000297518.4, ENST00000297518.4
    Conserved Domains (1) summary
    cl21453
    Location:3254
    PKc_like; Protein Kinases, catalytic domain
  2. NM_004935.4NP_004926.1  cyclin-dependent-like kinase 5 isoform 1

    See identical proteins and their annotated locations for NP_004926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK026533, BC005115, BP309068, CA429180
    Consensus CDS
    CCDS47748.1
    UniProtKB/Swiss-Prot
    Q00535
    UniProtKB/TrEMBL
    A0A090N7W4
    Related
    ENSP00000419782.1, ENST00000485972.6
    Conserved Domains (1) summary
    cd07839
    Location:3286
    STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    151053815..151057897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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