1UNL,1H4L,1UNG


Conserved Protein Domain Family
STKc_CDK5

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cd07839: STKc_CDK5 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 143344
View PSSM: cd07839
Aligned: 14 rows
Threshold Bit Score: 536.246
Threshold Setting Gi: 167522771
Created: 18-Jul-2006
Updated: 2-Mar-2014
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ####    #            # #                              #               ###
1UNL_B         3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82
1H4L_B         3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82
1UNG_A         3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82
gi 12644288    3 KYDKMEKIGEGTYGTVFKGRNRdtmEIVALKRVRLDEDDEGVPSSALREICLLKELkHKNIVRLIDVLHsdKKLTLVFEH 82
gi 1705719     3 KYEKLEKIGEGTYGTVFKAKNRdthEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82
gi 17552716    3 NYDKMEKIGEGTYGTVFKARNKnsgEIVALKRVRLDDDDEGVPSSALREICILRELkHRNVVRLYDVVHseNKLTLVFEY 82
gi 56753669    8 KYEKLEKIGEGTYGKVYKARNRethEIVALKRVRLENDDEGIPSSAFREICLLKELkHKNIVRLFDVLLsdSRLTIVFEY 87
gi 156407302   3 KYDKLEKIGEGTYGTVFKGKNKetrEILALKRVRLDDDDEGVPSSALREICLLKELkHNNIVRLYDVLHseKKLTLVFEF 82
gi 198422386   3 KYEKIEKIGEGTYGTVFKAKNResgEVVALKRVQLDDDDEGVPSSALREICILKELkHKNVVRLHDVLHseRKMTLVFEY 82
gi 209417930   3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #  #                                        ## #          #                  
1UNL_B        83 CDQDLKKYFDsCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLANFGLARAFGIPVRCYSAEV 162
1H4L_B        83 CDQDLKKYFDsCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162
1UNG_A        83 CDQDLKKYFDsCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLANFGLARAFGIPVRCYSAEV 162
gi 12644288   83 CDQDLKKYFDsLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEV 162
gi 1705719    83 CDQDLKKYFDsCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162
gi 17552716   83 CDQDLKKFFDsLNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEV 162
gi 56753669   88 CDQDLKKYFDnCNGEIDQNTVKLFMFQLLRGLQFCHSHNVLHRDLKPQNLLINDNGELKLADFGLARAYGIPVRQYSAEV 167
gi 156407302  83 CDQDLKKYFDsCQGEVDASVVKSFMFQLLRGLAFCHSHNVLHRDLKPQNLLINKDGELKLADFGLARAFGIPVRCFSAEV 162
gi 198422386  83 CEQDLKKYFDsCGGEIDRPTVQSFMYQLLKGLAFCHQQNILHRDLKPQNLLINKNGELKLADFGLARSFGIPVRCYSAEV 162
gi 209417930  83 CDQDLKKYFDsCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1UNL_B       163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY-KPYPM 241
1H4L_B       163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAaRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY-KPYPM 241
1UNG_A       163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY-KPYPM 241
gi 12644288  163 VTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAgRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDY-VALPS 241
gi 1705719   163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDY-KPYPM 241
gi 17552716  163 VTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAgRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDY-KPYPI 241
gi 56753669  168 VTLWYRPPDVLLGAKLYTTSIDMWSAGCIFAEMSNAgRPLFPGYDVEDQLQRIFKLLGTPTESTWPSVVELPDYePFTVM 247
gi 156407302 163 VTLWYRPPDVLMGAKLYSTSIDMWSAGCIFAEMANGgRPLFPGNDVDDQLRRIFKILGTPTEESWPNVSKLPDY-KEFPP 241
gi 198422386 163 VTLWYRPPDVLFGAKLYSTTIDTWSAGCIFAEISNAgVPLFPGNDVEDQLKRIFKVLGTPTEQSWPGVSKLPDF-KIFPL 241
gi 209417930 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMAKLPDY-KPYPM 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
Feature 1                                                     
1UNL_B       242 YPATTSlVNVVPKlnATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
1H4L_B       242 YPATTSlVNVVPKlnATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
1UNG_A       242 YPATTSlVNVVPKlnATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
gi 12644288  242 FPAITSwSQLVPRlnSKGRDLLQKLLICRPNQRISAEAAMQHPYF 286
gi 1705719   242 YPATMSlVNVVPKlnATGRDLLQNLLKCNPVQRICADEALQHPYF 286
gi 17552716  242 YHPTLTwSQIVPNlnSRGRDLLQKLLVCNPAGRIDADAALRHAYF 286
gi 56753669  248 YPRIMNwHHVVPKmsFRGRDLLQQLVACNPVDRISADQALKHSYF 292
gi 156407302 242 QGPSVSlGMVVPKlsSTGRDLLQKLLVSNPAHRISAEDAMKHAYF 286
gi 198422386 242 YPSNAHwAAITPRlsSSGHDLLKCLIVANPSERLTASNALKHRYF 286
gi 209417930 242 YPATTSlVNVVPKlnATGRDLLQNLLKVHPVQRISAEEALQHPYF 286

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