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Cdk5 cyclin dependent kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 12568, updated on 8-Feb-2024

Summary

Official Symbol
Cdk5provided by MGI
Official Full Name
cyclin dependent kinase 5provided by MGI
Primary source
MGI:MGI:101765
See related
Ensembl:ENSMUSG00000028969 AllianceGenome:MGI:101765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crk6
Summary
Enables several functions, including Hsp90 protein binding activity; acetylcholine receptor activator activity; and signaling receptor binding activity. Involved in regulation of dendritic spine morphogenesis; regulation of glutamatergic synaptic transmission; and regulation of protein localization to plasma membrane. Acts upstream of or within several processes, including chemical synaptic transmission; nervous system development; and regulation of intracellular protein transport. Located in several cellular components, including axon; filopodium; and lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 36.7), CNS E14 (RPKM 31.7) and 28 other tissues See more
Orthologs
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Genomic context

See Cdk5 in Genome Data Viewer
Location:
5 A3; 5 11.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24612595..24628737, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24407597..24423587, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15589 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:23853089-23853272 Neighboring gene STARR-positive B cell enhancer ABC_E10309 Neighboring gene nitric oxide synthase 3, endothelial cell Neighboring gene STARR-positive B cell enhancer ABC_E4747 Neighboring gene STARR-positive B cell enhancer ABC_E1677 Neighboring gene autophagy related 9B Neighboring gene ATP-binding cassette, sub-family B member 8 Neighboring gene STARR-positive B cell enhancer ABC_E9251 Neighboring gene acid-sensing ion channel 3 Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene predicted gene, 22333 Neighboring gene Fas-activated serine/threonine kinase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ErbB-2 class receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ErbB-3 class receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables acetylcholine receptor activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables histone kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar cortex formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within corpus callosum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within layer formation in cerebral cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcium ion-dependent exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of presynaptic cytosolic calcium concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse pruning ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within serine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within telencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase 5 complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 5
Names
CR6 protein kinase
TPKII catalytic subunit
cell division protein kinase 5
cyclin-dependent-like kinase 5
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
NP_031694.1
XP_006535689.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007668.4NP_031694.1  cyclin-dependent kinase 5

    See identical proteins and their annotated locations for NP_031694.1

    Status: VALIDATED

    Source sequence(s)
    AI550418, AK051790, BY126868
    Consensus CDS
    CCDS51434.1
    UniProtKB/Swiss-Prot
    P49615
    UniProtKB/TrEMBL
    Q543F6
    Related
    ENSMUSP00000030814.7, ENSMUST00000030814.11
    Conserved Domains (1) summary
    cd07839
    Location:3286
    STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5

RNA

  1. NR_156449.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113055

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24612595..24628737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535626.4XP_006535689.1  cyclin-dependent kinase 5 isoform X1

    Conserved Domains (1) summary
    cd07839
    Location:3264
    STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5