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RBM7 RNA binding motif protein 7 [ Homo sapiens (human) ]

Gene ID: 10179, updated on 9-Dec-2018

Summary

Official Symbol
RBM7provided by HGNC
Official Full Name
RNA binding motif protein 7provided by HGNC
Primary source
HGNC:HGNC:9904
See related
Ensembl:ENSG00000076053 MIM:612413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 12.9), urinary bladder (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See RBM7 in Genome Data Viewer
Location:
11q23.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (114400529..114410610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114271283..114279636)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nicotinamide N-methyltransferase Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391 Neighboring gene chromosome 11 open reading frame 71 Neighboring gene nocturnin pseudogene Neighboring gene RNA exonuclease 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RNA binding motif protein 7 (RBM7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11153

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286045.1NP_001272974.1  RNA-binding protein 7 isoform a

    See identical proteins and their annotated locations for NP_001272974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK002015, AK225615, AP002373, DA027521
    Consensus CDS
    CCDS66233.1
    UniProtKB/Swiss-Prot
    Q9Y580
    UniProtKB/TrEMBL
    J3KPD3
    Related
    ENSP00000364639.5, ENST00000375490.9
    Conserved Domains (2) summary
    COG0724
    Location:984
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12592
    Location:983
    RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)
  2. NM_001286046.1NP_001272975.1  RNA-binding protein 7 isoform c

    See identical proteins and their annotated locations for NP_001272975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c).
    Source sequence(s)
    AP002373, BC013320, BC034381, DA027521
    Consensus CDS
    CCDS73395.1
    UniProtKB/Swiss-Prot
    Q9Y580
    UniProtKB/TrEMBL
    G3V1T9
  3. NM_001286047.1NP_001272976.1  RNA-binding protein 7 isoform c

    See identical proteins and their annotated locations for NP_001272976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c).
    Source sequence(s)
    AP002373, BC034381, CN308273, DA027521
    Consensus CDS
    CCDS73395.1
    UniProtKB/Swiss-Prot
    Q9Y580
    UniProtKB/TrEMBL
    G3V1T9
    Related
    ENSP00000485655.1, ENST00000624815.3
  4. NM_001286048.1NP_001272977.1  RNA-binding protein 7 isoform c

    See identical proteins and their annotated locations for NP_001272977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c).
    Source sequence(s)
    AP002373, BC034381, BQ067937, DA027521
    Consensus CDS
    CCDS73395.1
    UniProtKB/Swiss-Prot
    Q9Y580
    UniProtKB/TrEMBL
    G3V1T9
    Related
    ENSP00000445848.1, ENST00000545678.1
  5. NM_016090.3NP_057174.1  RNA-binding protein 7 isoform b

    See identical proteins and their annotated locations for NP_057174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AP002373, BC034381, DA027521
    Consensus CDS
    CCDS8370.1
    UniProtKB/Swiss-Prot
    Q9Y580
    Related
    ENSP00000439918.1, ENST00000540163.5
    Conserved Domains (2) summary
    cd12592
    Location:983
    RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)
    cl25617
    Location:10238
    LSM_int_assoc; LSM-interacting associated unstructured

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    114400529..114410610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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