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REXO2 RNA exonuclease 2 [ Homo sapiens (human) ]

Gene ID: 25996, updated on 23-Aug-2020

Summary

Official Symbol
REXO2provided by HGNC
Official Full Name
RNA exonuclease 2provided by HGNC
Primary source
HGNC:HGNC:17851
See related
Ensembl:ENSG00000076043 MIM:607149
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFN; SFN; REX2; CGI-114
Summary
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in heart (RPKM 41.6), kidney (RPKM 38.9) and 25 other tissues See more
Orthologs

Genomic context

See REXO2 in Genome Data Viewer
Location:
11q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (114439467..114450279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114310108..114321001)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 71 Neighboring gene RNA binding motif protein 7 Neighboring gene nocturnin pseudogene Neighboring gene neurexophilin and PC-esterase domain family member 2 Neighboring gene neurexophilin and PC-esterase domain family member 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RBM7

Homology

Clone Names

  • MGC111570, DKFZp566E144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
focal adhesion IDA
Inferred from Direct Assay
more info
 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
oligoribonuclease, mitochondrial
Names
REX2, RNA exonuclease 2 homolog
RNA exonuclease 2 homolog
small fragment nuclease

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015523.4NP_056338.2  oligoribonuclease, mitochondrial precursor

    See identical proteins and their annotated locations for NP_056338.2

    Status: REVIEWED

    Source sequence(s)
    AI249345, BC143701
    Consensus CDS
    CCDS8371.1
    UniProtKB/Swiss-Prot
    Q9Y3B8
    Related
    ENSP00000265881.5, ENST00000265881.10
    Conserved Domains (1) summary
    cd06135
    Location:43215
    Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    114439467..114450279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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