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ZNF197 zinc finger protein 197 [ Homo sapiens (human) ]

Gene ID: 10168, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF197provided by HGNC
Official Full Name
zinc finger protein 197provided by HGNC
Primary source
HGNC:HGNC:12988
See related
Ensembl:ENSG00000186448 MIM:618359; AllianceGenome:HGNC:12988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P18; VHLaK; ZNF20; ZNF166; ZKSCAN9; ZSCAN41; D3S1363E
Summary
This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in thyroid (RPKM 4.1), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF197 in Genome Data Viewer
Location:
3p21.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44625036..44648471)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44640750..44664179)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44666528..44689963)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 35 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. Pengue G, et al. Hum Mol Genet, 1993 Jun. PMID 8353497
  2. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Gonsky R, et al. Nucleic Acids Res, 1997 Oct 1. PMID 9380504, Free PMC Article
  3. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. Calabrò V, et al. Hum Genet, 1995 Jan. PMID 7814019
  4. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. Li Z, et al. EMBO J, 2003 Apr 15. PMID 12682018, Free PMC Article
  5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF660-ZNF197

Readthrough gene: ZNF660-ZNF197, Included gene: ZNF660

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 197
Names
VHL-associated KRAB-A domain-containing protein
pVHL-associated KRAB domain-containing protein
zinc finger protein 166
zinc finger protein 20
zinc finger protein with KRAB and SCAN domains 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024855.3 → NP_001020026.1  zinc finger protein 197 isoform 2

    See identical proteins and their annotated locations for NP_001020026.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AY074878, AY279353
    UniProtKB/Swiss-Prot
    O14709
    Related
    ENSP00000373251.2, ENST00000383745.6
    Conserved Domains (2) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    pfam01352
    Location:216 → 257
    KRAB; KRAB box

  2. NM_001323293.2 → NP_001310222.1  zinc finger protein 197 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC099669, BQ002665
    UniProtKB/Swiss-Prot
    B2RAH8, O14709, Q86VG0
    Related
    ENSP00000379370.1, ENST00000396058.1
    Conserved Domains (5) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    COG5048
    Location:424 → 853
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400 → 420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:216 → 256
    KRAB; KRAB box
    pfam13465
    Location:384 → 409
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001323294.2 → NP_001310223.1  zinc finger protein 197 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC099669, AY279353, BQ002665
    UniProtKB/Swiss-Prot
    O14709
    Related
    ENSP00000373250.4, ENST00000383744.8
    Conserved Domains (2) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    pfam01352
    Location:216 → 257
    KRAB; KRAB box

  4. NM_001323295.2 → NP_001310224.1  zinc finger protein 197 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC099669, BQ002665
    Conserved Domains (6) summary
    smart00349
    Location:14 → 54
    KRAB; krueppel associated box
    COG5048
    Location:221 → 650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:197 → 217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:615 → 637
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:685 → 710
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001323296.2 → NP_001310225.1  zinc finger protein 197 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC099669, BQ002665
    Conserved Domains (6) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    COG5048
    Location:211 → 640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:605 → 627
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:675 → 700
    zf-H2C2_2; Zinc-finger double domain

  6. NM_006991.5 → NP_008922.1  zinc finger protein 197 isoform 1

    See identical proteins and their annotated locations for NP_008922.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC099669, AY261677, AY279353, BQ002665
    UniProtKB/Swiss-Prot
    B2RAH8, O14709, Q86VG0
    Related
    ENSP00000345809.4, ENST00000344387.9
    Conserved Domains (5) summary
    smart00431
    Location:38 → 150
    SCAN; leucine rich region
    COG5048
    Location:424 → 853
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400 → 420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:216 → 256
    KRAB; KRAB box
    pfam13465
    Location:384 → 409
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_136582.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099669, AY279353, BC031209

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44625036..44648471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    150390..173825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44640750..44664179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14709.1 GenPept UniProtKB/Swiss-Prot:O14709

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