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ZNF197 zinc finger protein 197 [ Homo sapiens (human) ]

Gene ID: 10168, updated on 5-Jan-2022

Summary

Official Symbol
ZNF197provided by HGNC
Official Full Name
zinc finger protein 197provided by HGNC
Primary source
HGNC:HGNC:12988
See related
Ensembl:ENSG00000186448 MIM:618359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P18; VHLaK; ZNF20; ZNF166; ZKSCAN9; ZSCAN41; D3S1363E
Summary
This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in thyroid (RPKM 4.1), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF197 in Genome Data Viewer
Location:
3p21.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44625036..44648471)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44666528..44689963)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene zinc finger protein 35 Neighboring gene zinc finger protein 251 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF660-ZNF197

Readthrough gene: ZNF660-ZNF197, Included gene: ZNF660

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 197
Names
VHL-associated KRAB-A domain-containing protein
pVHL-associated KRAB domain-containing protein
zinc finger protein 166
zinc finger protein 20
zinc finger protein with KRAB and SCAN domains 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024855.3NP_001020026.1  zinc finger protein 197 isoform 2

    See identical proteins and their annotated locations for NP_001020026.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AY074878, AY279353
    Consensus CDS
    CCDS33743.1
    UniProtKB/Swiss-Prot
    O14709
    Related
    ENSP00000373251.2, ENST00000383745.6
    Conserved Domains (2) summary
    smart00431
    Location:38150
    SCAN; leucine rich region
    pfam01352
    Location:216257
    KRAB; KRAB box
  2. NM_001323293.2NP_001310222.1  zinc finger protein 197 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC099669, BQ002665
    Consensus CDS
    CCDS2717.1
    UniProtKB/Swiss-Prot
    O14709
    Related
    ENSP00000379370.1, ENST00000396058.1
    Conserved Domains (5) summary
    smart00431
    Location:38150
    SCAN; leucine rich region
    COG5048
    Location:424853
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:216256
    KRAB; KRAB box
    pfam13465
    Location:384409
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001323294.2NP_001310223.1  zinc finger protein 197 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC099669, AY279353, BQ002665
    Consensus CDS
    CCDS33743.1
    UniProtKB/Swiss-Prot
    O14709
    Related
    ENSP00000373250.4, ENST00000383744.8
    Conserved Domains (2) summary
    smart00431
    Location:38150
    SCAN; leucine rich region
    pfam01352
    Location:216257
    KRAB; KRAB box
  4. NM_001323295.2NP_001310224.1  zinc finger protein 197 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC099669, BQ002665
    Conserved Domains (6) summary
    smart00349
    Location:1454
    KRAB; krueppel associated box
    COG5048
    Location:221650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:197217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:615637
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:685710
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001323296.2NP_001310225.1  zinc finger protein 197 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC099669, BQ002665
    Conserved Domains (6) summary
    smart00349
    Location:444
    KRAB; krueppel associated box
    COG5048
    Location:211640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:605627
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:675700
    zf-H2C2_2; Zinc-finger double domain
  6. NM_006991.5NP_008922.1  zinc finger protein 197 isoform 1

    See identical proteins and their annotated locations for NP_008922.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC099669, AY261677, AY279353, BQ002665
    Consensus CDS
    CCDS2717.1
    UniProtKB/Swiss-Prot
    O14709
    UniProtKB/TrEMBL
    Q7Z6G1
    Related
    ENSP00000345809.4, ENST00000344387.9
    Conserved Domains (5) summary
    smart00431
    Location:38150
    SCAN; leucine rich region
    COG5048
    Location:424853
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:216256
    KRAB; KRAB box
    pfam13465
    Location:384409
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_136582.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099669, AY279353, BC031209

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44625036..44648471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p13 PATCHES

    Range
    150390..173825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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