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ZNF660 zinc finger protein 660 [ Homo sapiens (human) ]

Gene ID: 285349, updated on 5-Sep-2021

Summary

Official Symbol
ZNF660provided by HGNC
Official Full Name
zinc finger protein 660provided by HGNC
Primary source
HGNC:HGNC:26720
See related
Ensembl:ENSG00000144792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that contains multiple C2H2 zinc finger domains, and is located in a cluster of zinc-finger encoding genes on chromosome 3. Naturally-occurring readthrough transcription is observed between this gene and the downstream zinc finger protein 197 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]
Expression
Broad expression in ovary (RPKM 1.9), endometrium (RPKM 1.3) and 22 other tissues See more
Orthologs
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Genomic context

See ZNF660 in Genome Data Viewer
Location:
3p21.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44584964..44599694)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44626456..44641186)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15293 Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene zinc finger with KRAB and SCAN domains 7 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene myosin phosphatase Rho interacting protein pseudogene 1 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene zinc finger protein 197

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF660-ZNF197

Readthrough gene: ZNF660-ZNF197, Included gene: ZNF197

Homology

Clone Names

  • FLJ36870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054906.1 RefSeqGene

    Range
    5116..19846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173658.4NP_775929.2  zinc finger protein 660

    See identical proteins and their annotated locations for NP_775929.2

    Status: REVIEWED

    Source sequence(s)
    AC099669, AK094189, BC075094
    Consensus CDS
    CCDS2716.1
    UniProtKB/Swiss-Prot
    Q6AZW8
    Related
    ENSP00000324605.2, ENST00000322734.2
    Conserved Domains (3) summary
    COG5048
    Location:107294
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:5272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:6489
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44584964..44599694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p13 PATCHES

    Range
    110318..125048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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