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ptpn4a protein tyrosine phosphatase non-receptor type 4a [ Oryzias latipes (Japanese medaka) ]

Gene ID: 101171899, updated on 8-Mar-2024

Summary

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Gene symbol
ptpn4a
Gene description
protein tyrosine phosphatase non-receptor type 4a
See related
EnsemblRapid:ENSORLG00000020845
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Also known as
ptpn4
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 21
Exon count:
27
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 21 NC_019879.2 (31022454..31059083, complement)
102 previous assembly ASM31367v1 (GCF_000313675.1) Unplaced Scaffold NW_004095216.1 (210302..258592)

Chromosome 21 - NC_019879.2Genomic Context describing neighboring genes Neighboring gene neuropilin-2 Neighboring gene uncharacterized LOC110014889 Neighboring gene erythrocyte membrane protein band 4.1 like 5 Neighboring gene ribosomal RNA processing protein 1 homolog A Neighboring gene transmembrane protein 177

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 4
Names
protein tyrosine phosphatase non-receptor type 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019879.2 Reference ASM223467v1 Primary Assembly

    Range
    31022454..31059083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023950763.1 → XP_023806531.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

    UniProtKB/TrEMBL
    A0A3P9H7F9
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:693 → 920
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:519 → 606
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)

  2. XM_023950764.1 → XP_023806532.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

    UniProtKB/TrEMBL
    A0A3P9H7F9, H2N2X7
    Related
    ENSORLP00000025817.3, ENSORLT00000025818.3
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:686 → 913
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:519 → 606
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)
Nucleotide Protein
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