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DLG4 discs large MAGUK scaffold protein 4 [ Felis catus (domestic cat) ]

Gene ID: 101093902, updated on 17-Aug-2024

Summary

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Official Symbol
DLG4
Official Full Name
discs large MAGUK scaffold protein 4
Primary source
VGNC:VGNC:61512
See related
EnsemblRapid:ENSFCTG00005011909
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: E1
Exon count:
25
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) E1 NC_058381.1 (2149379..2171923, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) E1 NC_018736.3 (2158225..2181425, complement)

Chromosome E1 - NC_058381.1Genomic Context describing neighboring genes Neighboring gene asialoglycoprotein receptor 1 Neighboring gene uncharacterized LOC109494155 Neighboring gene acyl-CoA dehydrogenase very long chain Neighboring gene uncharacterized LOC109494156 Neighboring gene dishevelled segment polarity protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in AMPA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disks large homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058381.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    2149379..2171923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019817072.3 → XP_019672631.1  disks large homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (7) summary
    cd12030
    Location:506 → 571
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:386 → 470
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:141 → 225
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:609 → 787
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:321 → 388
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:54 → 140
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cl02672
    Location:26 → 47
    L27; L27 domain

  2. XM_019817080.3 → XP_019672639.1  disks large homolog 4 isoform X8

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Related
    ENSFCTP00005023349.1, ENSFCTT00005034313.1
    Conserved Domains (7) summary
    cd12030
    Location:470 → 535
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:350 → 434
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:105 → 189
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:573 → 751
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:285 → 352
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:54 → 104
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cl02672
    Location:26 → 47
    L27; L27 domain

  3. XM_019817078.3 → XP_019672637.1  disks large homolog 4 isoform X7

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (7) summary
    cd12030
    Location:472 → 537
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:352 → 436
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:107 → 191
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:575 → 753
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:287 → 354
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:53 → 106
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cl02672
    Location:26 → 47
    L27; L27 domain

  4. XM_019817076.3 → XP_019672635.1  disks large homolog 4 isoform X6

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (7) summary
    cd12030
    Location:473 → 538
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:353 → 437
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:108 → 192
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:576 → 754
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:288 → 355
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:54 → 107
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cl02672
    Location:26 → 47
    L27; L27 domain

  5. XM_045045053.1 → XP_044900988.1  disks large homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (5) summary
    cd12030
    Location:370 → 435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250 → 334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:5 → 89
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473 → 651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185 → 252
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  6. XM_023243655.2 → XP_023099423.1  disks large homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Related
    ENSFCTP00005023473.1, ENSFCTT00005034466.1
    Conserved Domains (5) summary
    cd12030
    Location:370 → 435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250 → 334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:5 → 89
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473 → 651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185 → 252
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  7. XM_019817081.3 → XP_019672640.1  disks large homolog 4 isoform X9

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Related
    ENSFCTP00005023233.1, ENSFCTT00005034170.1
    Conserved Domains (6) summary
    cd12030
    Location:463 → 528
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:343 → 427
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:98 → 182
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:566 → 744
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278 → 345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 97
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  8. XM_019817086.3 → XP_019672645.1  disks large homolog 4 isoform X15

    UniProtKB/TrEMBL
    A0A2I2UWA7, M3VZ73
    Related
    ENSFCTP00005023089.1, ENSFCTT00005033998.1
    Conserved Domains (6) summary
    cd12030
    Location:405 → 470
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:285 → 369
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:40 → 124
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:508 → 686
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:220 → 287
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:7 → 39
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  9. XM_019817084.3 → XP_019672643.1  disks large homolog 4 isoform X14

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (6) summary
    cd12030
    Location:407 → 472
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:287 → 371
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:42 → 126
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:510 → 688
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:222 → 289
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 41
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  10. XM_011288884.4 → XP_011287186.1  disks large homolog 4 isoform X11

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (7) summary
    cd12030
    Location:429 → 494
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:543 → 709
    GuKc; Guanylate kinase homologues
    smart00228
    Location:309 → 393
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:64 → 148
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:532 → 710
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:244 → 311
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 63
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  11. XM_019817083.3 → XP_019672642.1  disks large homolog 4 isoform X13

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Related
    ENSFCTP00005023406.1, ENSFCTT00005034385.1
    Conserved Domains (6) summary
    cd12030
    Location:408 → 473
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:288 → 372
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:43 → 127
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:511 → 689
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:223 → 290
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:7 → 42
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  12. XM_011288885.4 → XP_011287187.1  disks large homolog 4 isoform X12

    UniProtKB/TrEMBL
    A0A2I2U784, A0A2I2UWA7
    Conserved Domains (6) summary
    cd12030
    Location:427 → 492
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:307 → 391
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:62 → 146
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:530 → 708
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:242 → 309
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 61
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  13. XM_011288883.4 → XP_011287185.1  disks large homolog 4 isoform X10

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (6) summary
    cd12030
    Location:430 → 495
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:310 → 394
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:65 → 149
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:533 → 711
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245 → 312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:10 → 64
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  14. XM_023243653.2 → XP_023099421.1  disks large homolog 4 isoform X5

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Related
    ENSFCTP00005023152.1, ENSFCTT00005034072.1
    Conserved Domains (6) summary
    cd12030
    Location:431 → 496
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:311 → 395
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:66 → 150
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:534 → 712
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:246 → 313
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:15 → 65
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  15. XM_023243652.2 → XP_023099420.1  disks large homolog 4 isoform X4

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (6) summary
    cd12030
    Location:433 → 498
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:313 → 397
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:68 → 152
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:536 → 714
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:248 → 315
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:15 → 67
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  16. XM_019817082.3 → XP_019672641.1  disks large homolog 4 isoform X3

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (6) summary
    cd12030
    Location:434 → 499
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:314 → 398
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:69 → 153
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:537 → 715
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:249 → 316
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:15 → 68
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  17. XM_023243651.2 → XP_023099419.1  disks large homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A2I2UWA7
    Conserved Domains (5) summary
    cd12030
    Location:370 → 435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250 → 334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:5 → 89
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473 → 651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185 → 252
    PDZ_assoc; PDZ-associated domain of NMDA receptors

RNA

  1. XR_006589829.1 RNA Sequence

    Related
    ENSFCTT00005033809.1
Nucleotide Protein
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