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TSPAN5 tetraspanin 5 [ Homo sapiens (human) ]

Gene ID: 10098, updated on 11-Apr-2024

Summary

Official Symbol
TSPAN5provided by HGNC
Official Full Name
tetraspanin 5provided by HGNC
Primary source
HGNC:HGNC:17753
See related
Ensembl:ENSG00000168785 MIM:613136; AllianceGenome:HGNC:17753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET4; NET-4; TM4SF9; TSPAN-5
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 32.0), ovary (RPKM 24.8) and 18 other tissues See more
Orthologs
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Genomic context

Location:
4q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (98470367..98658611, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (101785330..101973565, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99391518..99579762, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rap1 GTPase-GDP dissociation stimulator 1 Neighboring gene uncharacterized LOC124900919 Neighboring gene ribosomal protein L21 pseudogene 48 Neighboring gene Sharpr-MPRA regulatory region 12770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:99457519-99458032 Neighboring gene Sharpr-MPRA regulatory region 11258 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:99518736-99519334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21735 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:99574420-99575619 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:99579327-99579486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15578 Neighboring gene uncharacterized LOC112267901 Neighboring gene TSPAN5 divergent transcript Neighboring gene CRISPRi-validated cis-regulatory element chr4.2289 Neighboring gene CRISPRi-validated cis-regulatory element chr4.2290 Neighboring gene mitochondrial import receptor subunit TOM7 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tetraspanin 5 (TSPAN5) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tetraspanin-5
Names
tetraspan NET-4
tetraspan TM4SF
transmembrane 4 superfamily member 9
transmembrane 4 superfamily, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046902.1 RefSeqGene

    Range
    5051..193295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005723.4NP_005714.2  tetraspanin-5

    See identical proteins and their annotated locations for NP_005714.2

    Status: REVIEWED

    Source sequence(s)
    AC058823, AC114811, AI089708, BC009704
    Consensus CDS
    CCDS3646.1
    UniProtKB/Swiss-Prot
    B2RDY2, O60628, O60746, P62079, Q6FHE5, Q9JLY1
    UniProtKB/TrEMBL
    Q6FHC5
    Related
    ENSP00000307701.3, ENST00000305798.8
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:15257
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    98470367..98658611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262680.2XP_005262737.1  tetraspanin-5 isoform X1

    See identical proteins and their annotated locations for XP_005262737.1

    UniProtKB/TrEMBL
    Q6FHC5
    Conserved Domains (1) summary
    cd03159
    Location:64184
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. XM_047449475.1XP_047305431.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317
    Related
    ENSP00000423916.1, ENST00000505184.5
  3. XM_047449473.1XP_047305429.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317
  4. XM_047449472.1XP_047305428.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317
  5. XM_047449477.1XP_047305433.1  tetraspanin-5 isoform X4

  6. XM_047449476.1XP_047305432.1  tetraspanin-5 isoform X3

    UniProtKB/TrEMBL
    D6RAR1
    Related
    ENSP00000421808.1, ENST00000508798.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    101785330..101973565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348694.1XP_054204669.1  tetraspanin-5 isoform X1

  2. XM_054348695.1XP_054204670.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    B7Z317
  3. XM_054348697.1XP_054204672.1  tetraspanin-5 isoform X4

  4. XM_054348696.1XP_054204671.1  tetraspanin-5 isoform X3

    UniProtKB/TrEMBL
    D6RAR1