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TSPAN5 tetraspanin 5 [ Homo sapiens (human) ]

Gene ID: 10098, updated on 10-Oct-2019

Summary

Official Symbol
TSPAN5provided by HGNC
Official Full Name
tetraspanin 5provided by HGNC
Primary source
HGNC:HGNC:17753
See related
Ensembl:ENSG00000168785 MIM:613136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET4; NET-4; TM4SF9; TSPAN-5
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 32.0), ovary (RPKM 24.8) and 18 other tissues See more
Orthologs

Genomic context

See TSPAN5 in Genome Data Viewer
Location:
4q23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (98470367..98658661, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99391518..99579812, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377340 Neighboring gene Rap1 GTPase-GDP dissociation stimulator 1 Neighboring gene ribosomal protein L21 pseudogene 48 Neighboring gene uncharacterized LOC112267901 Neighboring gene uncharacterized LOC105377342 Neighboring gene mitochondrial import receptor subunit TOM7 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tetraspanin 5 (TSPAN5) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tetraspanin-5
Names
tetraspan NET-4
tetraspan TM4SF
transmembrane 4 superfamily member 9
transmembrane 4 superfamily, member 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046902.1 RefSeqGene

    Range
    5051..193295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005723.4NP_005714.2  tetraspanin-5

    See identical proteins and their annotated locations for NP_005714.2

    Status: REVIEWED

    Source sequence(s)
    AC058823, AC114811, AI089708, BC009704
    Consensus CDS
    CCDS3646.1
    UniProtKB/Swiss-Prot
    P62079
    Related
    ENSP00000307701.3, ENST00000305798.8
    Conserved Domains (2) summary
    cd03159
    Location:113233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:15254
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    98470367..98658661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262680.1XP_005262737.1  tetraspanin-5 isoform X1

    See identical proteins and their annotated locations for XP_005262737.1

    Conserved Domains (1) summary
    cd03159
    Location:64184
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

  1. XR_001741092.1 RNA Sequence

  2. XR_244617.1 RNA Sequence

    Related
    ENST00000508798.5
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