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ARPC4 actin related protein 2/3 complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 10093, updated on 7-Jun-2020

Summary

Official Symbol
ARPC4provided by HGNC
Official Full Name
actin related protein 2/3 complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:707
See related
Ensembl:ENSG00000241553 MIM:604226
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC20; P20-ARC
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in lymph node (RPKM 63.0), appendix (RPKM 61.6) and 25 other tissues See more
Orthologs

Genomic context

See ARPC4 in Genome Data Viewer
Location:
3p25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9792495..9807724)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9834082..9848789)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene transcriptional adaptor 3 Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify 20kDa subunit 4 of actin related protein 2/3 complex (ARPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify 20kDa subunit 4 of actin related protein 2/3 complex (ARPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify 20kDa subunit 4 of actin related protein 2/3 complex (ARPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify 20kDa subunit 4 of actin related protein 2/3 complex (ARPC4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ARPC4-TTLL3

Readthrough gene: ARPC4-TTLL3, Included gene: TTLL3

Homology

  • Homologs of the ARPC4 gene: The ARPC4 gene is conserved in chimpanzee, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 216 organisms have orthologs with human gene ARPC4

Clone Names

  • MGC13544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to actin filament binding NAS
Non-traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein binding, bridging IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
actin nucleation NAS
Non-traceable Author Statement
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Arp2/3 protein complex TAS
Traceable Author Statement
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 4
Names
actin related protein 2/3 complex, subunit 4, 20kDa
arp2/3 complex 20 kDa subunit
arp2/3 protein complex subunit p20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024959.2NP_001020130.1  actin-related protein 2/3 complex subunit 4 isoform b

    See identical proteins and their annotated locations for NP_001020130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC022382, AI612891, BQ688329, DB060690
    Consensus CDS
    CCDS46743.1
    UniProtKB/Swiss-Prot
    P59998
    Related
    ENSP00000432235.1, ENST00000498623.6
    Conserved Domains (1) summary
    cl05433
    Location:176
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)
  2. NM_001024960.2NP_001020131.1  actin-related protein 2/3 complex subunit 4 isoform b

    See identical proteins and their annotated locations for NP_001020131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC022382, AI612891, BG938423, DA226584
    Consensus CDS
    CCDS46743.1
    UniProtKB/Swiss-Prot
    P59998
    Related
    ENSP00000473435.1, ENST00000485273.1
    Conserved Domains (1) summary
    cl05433
    Location:176
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)
  3. NM_001198780.2NP_001185709.1  actin-related protein 2/3 complex subunit 4 isoform c

    See identical proteins and their annotated locations for NP_001185709.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (c) is longer than isoform a.
    Source sequence(s)
    AC022382, AI612891, BX419672
    Consensus CDS
    CCDS56238.1
    UniProtKB/Swiss-Prot
    P59998
    Related
    ENSP00000388169.1, ENST00000433034.1
    Conserved Domains (1) summary
    pfam05856
    Location:21185
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)
  4. NM_005718.4NP_005709.1  actin-related protein 2/3 complex subunit 4 isoform a

    See identical proteins and their annotated locations for NP_005709.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AC022382, AF006087, AI612891, BI910730, DA909066
    Consensus CDS
    CCDS43047.1
    UniProtKB/Swiss-Prot
    P59998
    Related
    ENSP00000380431.2, ENST00000397261.7
    Conserved Domains (1) summary
    pfam05856
    Location:1166
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9792495..9807724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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