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TTLL3 tubulin tyrosine ligase like 3 [ Homo sapiens (human) ]

Gene ID: 26140, updated on 19-Oct-2019

Summary

Official Symbol
TTLL3provided by HGNC
Official Full Name
tubulin tyrosine ligase like 3provided by HGNC
Primary source
HGNC:HGNC:24483
See related
Ensembl:ENSG00000214021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOTTL
Expression
Ubiquitous expression in ovary (RPKM 13.9), testis (RPKM 13.9) and 24 other tissues See more
Orthologs

Genomic context

See TTLL3 in Genome Data Viewer
Location:
3p25.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9809915..9836365)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9851632..9878040)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene transcriptional adaptor 3 Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 1 Neighboring gene cell death inducing DFFA like effector c

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ARPC4-TTLL3

Readthrough gene: ARPC4-TTLL3, Included gene: ARPC4

Homology

Clone Names

  • FLJ13898, MGC120529, MGC120530, MGC120532, DKFZp434B103, DKFZp686D076

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-glycine ligase activity, initiating ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
axoneme assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein polyglycylation IDA
Inferred from Direct Assay
more info
PubMed 
protein polyglycylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tubulin monoglycylase TTLL3
Names
tubulin tyrosine ligase-like family, member 3
tubulin--tyrosine ligase-like protein 3
NP_001021100.3
NP_001352980.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025930.5NP_001021100.3  tubulin monoglycylase TTLL3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1), and represents use of a different promoter relative to variant 3.
    Source sequence(s)
    AC018809, AC022382, AK023960
    Consensus CDS
    CCDS43048.2
    UniProtKB/Swiss-Prot
    Q9Y4R7
    UniProtKB/TrEMBL
    J3KQB2
    Related
    ENSP00000392549.4, ENST00000426895.9
    Conserved Domains (1) summary
    pfam03133
    Location:356648
    TTL; Tubulin-tyrosine ligase family
  2. NM_001366051.2NP_001352980.1  tubulin monoglycylase TTLL3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR relative to variant 1, and represents use of a different promoter, resulting in the use of a downstream start codon relative to variant 1. The encoded isoform is shorter at the N-terminus relative to variant 1.
    Source sequence(s)
    AC018809, AC022382, AK023960
    Conserved Domains (1) summary
    pfam03133
    Location:213505
    TTL; Tubulin-tyrosine ligase family

RNA

  1. NR_037162.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' terminal exons, and includes alternate internal exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of multiple upstream ORFs that are predicted to inhibit the translation of the longest ORF; upstream ORF translation would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA742169, AC018809, AC022382, BC028169

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9809915..9836365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015644.3: Suppressed sequence

    Description
    NM_015644.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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