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ARPC4-TTLL3 ARPC4-TTLL3 readthrough [ Homo sapiens (human) ]

Gene ID: 100526693, updated on 7-Aug-2022

Summary

Official Symbol
ARPC4-TTLL3provided by HGNC
Official Full Name
ARPC4-TTLL3 readthroughprovided by HGNC
Primary source
HGNC:HGNC:38830
See related
Ensembl:ENSG00000250151 AllianceGenome:HGNC:38830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC20; ARPC4; p20-ARC
Summary
This locus represents naturally occurring read-through transcription between the neighboring ARPC4 (actin related protein 2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like family, member 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in lymph node (RPKM 18.9), bone marrow (RPKM 17.8) and 25 other tissues See more
Orthologs
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Genomic context

See ARPC4-TTLL3 in Genome Data Viewer
Location:
3p25.3
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (9792548..9836356)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (9784502..9828357)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9834232..9878040)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene Sharpr-MPRA regulatory region 4794 Neighboring gene transcriptional adaptor 3 Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene MARK2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14048

General protein information

Preferred Names
ARPC4-TTLL3 fusion protein
Names
ARPC4-TTLL3 read-through transcript
Actin-related protein 2/3 complex subunit 4
Arp2/3 complex 20 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198793.1NP_001185722.1  ARPC4-TTLL3 fusion protein

    Status: VALIDATED

    Source sequence(s)
    AC018809, AC022382, BC025289
    UniProtKB/TrEMBL
    A0A0A6YYG9
    Related
    ENSP00000380427.1, ENST00000397256.5
    Conserved Domains (2) summary
    pfam03133
    Location:274566
    TTL; Tubulin-tyrosine ligase family
    pfam05856
    Location:1110
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    9792548..9836356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    9784502..9828357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)