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PDCD7 programmed cell death 7 [ Homo sapiens (human) ]

Gene ID: 10081, updated on 5-Sep-2021

Summary

Official Symbol
PDCD7provided by HGNC
Official Full Name
programmed cell death 7provided by HGNC
Primary source
HGNC:HGNC:8767
See related
Ensembl:ENSG00000090470 MIM:608138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
59K; ES18; HES18
Summary
This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 10.7), ovary (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See PDCD7 in Genome Data Viewer
Location:
15q22.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65117379..65133808, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65409717..65426146, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 13 Neighboring gene ubiquitin associated protein 1 like Neighboring gene caseinolytic mitochondrial matrix peptidase chaperone subunit X Neighboring gene Sharpr-MPRA regulatory region 15221

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ54213, MGC22015

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in RNA splicing IC
Inferred by Curator
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
programmed cell death protein 7
Names
U11/U12 snRNP 59K
apoptosis-related protein ES18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005707.2NP_005698.1  programmed cell death protein 7

    See identical proteins and their annotated locations for NP_005698.1

    Status: REVIEWED

    Source sequence(s)
    AC013553, AK096970, BC016992
    Consensus CDS
    CCDS10201.1
    UniProtKB/Swiss-Prot
    Q8N8D1
    UniProtKB/TrEMBL
    Q6IEG3
    Related
    ENSP00000204549.4, ENST00000204549.9
    Conserved Domains (1) summary
    pfam16021
    Location:191481
    PDCD7; Programmed cell death protein 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65117379..65133808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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