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NR1H3 nuclear receptor subfamily 1 group H member 3 [ Homo sapiens (human) ]

Gene ID: 10062, updated on 11-Jun-2021

Summary

Official Symbol
NR1H3provided by HGNC
Official Full Name
nuclear receptor subfamily 1 group H member 3provided by HGNC
Primary source
HGNC:HGNC:7966
See related
Ensembl:ENSG00000025434 MIM:602423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LXRA; LXR-a; RLD-1
Summary
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in fat (RPKM 25.1), spleen (RPKM 16.7) and 23 other tissues See more
Orthologs
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Genomic context

See NR1H3 in Genome Data Viewer
Location:
11p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (47248300..47269033)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47269851..47290584)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 pseudogene 26 Neighboring gene damage specific DNA binding protein 2 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene Sharpr-MPRA regulatory region 2100 Neighboring gene Sharpr-MPRA regulatory region 9889 Neighboring gene MADD antisense RNA 1 Neighboring gene MAP kinase activating death domain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
GeneReviews: Not available
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA activates NR1H3 signaling in primary hepatocytes PubMed
gag HIV-1 MA upregulates NR1H3 mRNA expression in HepG2 cells and primary hepatocytes PubMed
gag HIV-1 MA upregulates NR1H3 (LXR-alpha) gene expresssion in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cholesterol storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interferon-gamma-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of lipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of pancreatic juice secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of pinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of secretion of lysosomal enzymes ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylcholine acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipoprotein lipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transporter activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
involved_in response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
involved_in triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
oxysterols receptor LXR-alpha
Names
liver X nuclear receptor alpha variant 1
NP_001123573.1
NP_001123574.1
NP_001238863.1
NP_001238864.1
NP_001350524.1
NP_005684.2
XP_005252763.1
XP_005252770.1
XP_005252775.1
XP_011518107.1
XP_011518108.1
XP_011518109.1
XP_011518110.1
XP_016872545.1
XP_016872546.1
XP_024304052.1
XP_024304053.1
XP_024304054.1
XP_024304055.1
XP_024304056.1
XP_024304057.1
XP_024304058.1
XP_024304059.1
XP_024304060.1
XP_024304061.1
XP_024304062.1
XP_024304063.1
XP_024304064.1
XP_024304065.1
XP_024304066.1
XP_024304067.1
XP_024304068.1
XP_024304070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030392.1 RefSeqGene

    Range
    5001..25734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130101.3NP_001123573.1  oxysterols receptor LXR-alpha isoform 2

    See identical proteins and their annotated locations for NP_001123573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AA644385, AI097478, AU133574, BC008819
    Consensus CDS
    CCDS44584.1
    UniProtKB/Swiss-Prot
    Q13133
    Related
    ENSP00000384745.3, ENST00000405853.7
    Conserved Domains (2) summary
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:210385
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. NM_001130102.3NP_001123574.1  oxysterols receptor LXR-alpha isoform 3

    See identical proteins and their annotated locations for NP_001123574.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks another exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA644385, AC018410, AI097478, AU135617, BC041172
    Consensus CDS
    CCDS44585.1
    UniProtKB/Swiss-Prot
    Q13133
    Related
    ENSP00000378793.3, ENST00000395397.7
    Conserved Domains (2) summary
    cd06954
    Location:165400
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  3. NM_001251934.2NP_001238863.1  oxysterols receptor LXR-alpha isoform 4

    See identical proteins and their annotated locations for NP_001238863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform.
    Source sequence(s)
    AA644385, AI097478, AK302132, AK311590
    Consensus CDS
    CCDS73285.1
    UniProtKB/TrEMBL
    B4DXU5
    Related
    ENST00000529540.5
    Conserved Domains (2) summary
    cd06954
    Location:216451
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:84184
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  4. NM_001251935.2NP_001238864.1  oxysterols receptor LXR-alpha isoform 4

    See identical proteins and their annotated locations for NP_001238864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform (4).
    Source sequence(s)
    AA644385, AI097478, AK302132, AK311590
    Consensus CDS
    CCDS73285.1
    UniProtKB/TrEMBL
    B4DXU5
    Related
    ENSP00000477707.1, ENST00000616973.4
    Conserved Domains (2) summary
    cd06954
    Location:216451
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:84184
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  5. NM_001363595.2NP_001350524.1  oxysterols receptor LXR-alpha isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC018410
    Consensus CDS
    CCDS86200.1
    Conserved Domains (2) summary
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:165340
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  6. NM_005693.4NP_005684.2  oxysterols receptor LXR-alpha isoform 1

    See identical proteins and their annotated locations for NP_005684.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AA644385, AI097478, AK290614, AK302132
    Consensus CDS
    CCDS7929.1
    UniProtKB/Swiss-Prot
    Q13133
    UniProtKB/TrEMBL
    B4DXU5, F1D8N1
    Related
    ENSP00000387946.2, ENST00000441012.7
    Conserved Domains (2) summary
    cd06954
    Location:210445
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    47248300..47269033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448299.1XP_024304067.1  oxysterols receptor LXR-alpha isoform X4

    Conserved Domains (1) summary
    cd06954
    Location:76375
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  2. XM_005252718.3XP_005252775.1  oxysterols receptor LXR-alpha isoform X13

    Conserved Domains (1) summary
    cl11397
    Location:76251
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. XM_024448292.1XP_024304060.1  oxysterols receptor LXR-alpha isoform X3

    Related
    ENSP00000433271.1, ENST00000481889.6
    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  4. XM_024448302.1XP_024304070.1  oxysterols receptor LXR-alpha isoform X12

    Conserved Domains (1) summary
    cd06954
    Location:1297
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  5. XM_024448288.1XP_024304056.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  6. XM_011519808.2XP_011518110.1  oxysterols receptor LXR-alpha isoform X14

    Conserved Domains (1) summary
    cd06954
    Location:1233
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  7. XM_005252713.3XP_005252770.1  oxysterols receptor LXR-alpha isoform X11

    See identical proteins and their annotated locations for XP_005252770.1

    UniProtKB/Swiss-Prot
    Q13133
    Related
    ENSP00000385801.1, ENST00000407404.5
    Conserved Domains (2) summary
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:210385
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  8. XM_024448294.1XP_024304062.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  9. XM_011519805.2XP_011518107.1  oxysterols receptor LXR-alpha isoform X5

    See identical proteins and their annotated locations for XP_011518107.1

    UniProtKB/Swiss-Prot
    Q13133
    UniProtKB/TrEMBL
    F1D8N1
    Conserved Domains (2) summary
    cd06954
    Location:210445
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  10. XM_024448298.1XP_024304066.1  oxysterols receptor LXR-alpha isoform X2

    Conserved Domains (2) summary
    cd06954
    Location:165400
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  11. XM_024448287.1XP_024304055.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  12. XM_005252706.1XP_005252763.1  oxysterols receptor LXR-alpha isoform X5

    See identical proteins and their annotated locations for XP_005252763.1

    UniProtKB/Swiss-Prot
    Q13133
    UniProtKB/TrEMBL
    F1D8N1
    Conserved Domains (2) summary
    cd06954
    Location:210445
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  13. XM_024448295.1XP_024304063.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  14. XM_024448284.1XP_024304052.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  15. XM_024448291.1XP_024304059.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  16. XM_024448300.1XP_024304068.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  17. XM_024448285.1XP_024304053.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  18. XM_024448286.1XP_024304054.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  19. XM_024448290.1XP_024304058.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  20. XM_024448297.1XP_024304065.1  oxysterols receptor LXR-alpha isoform X6

    Conserved Domains (1) summary
    cd06954
    Location:121420
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  21. XM_024448296.1XP_024304064.1  oxysterols receptor LXR-alpha isoform X4

    Conserved Domains (1) summary
    cd06954
    Location:76375
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  22. XM_011519807.1XP_011518109.1  oxysterols receptor LXR-alpha isoform X10

    See identical proteins and their annotated locations for XP_011518109.1

    Conserved Domains (1) summary
    cd06954
    Location:76311
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  23. XM_024448289.1XP_024304057.1  oxysterols receptor LXR-alpha isoform X2

    Conserved Domains (2) summary
    cd06954
    Location:165400
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  24. XM_011519806.1XP_011518108.1  oxysterols receptor LXR-alpha isoform X7

    UniProtKB/TrEMBL
    B5MBY7
    Related
    ENSP00000385073.1, ENST00000405576.5
    Conserved Domains (2) summary
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:165340
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  25. XM_017017056.1XP_016872545.1  oxysterols receptor LXR-alpha isoform X8

  26. XM_017017057.1XP_016872546.1  oxysterols receptor LXR-alpha isoform X9

  27. XM_024448293.1XP_024304061.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
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