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NR1H3 nuclear receptor subfamily 1 group H member 3 [ Homo sapiens (human) ]

Gene ID: 10062, updated on 12-May-2019

Summary

Official Symbol
NR1H3provided by HGNC
Official Full Name
nuclear receptor subfamily 1 group H member 3provided by HGNC
Primary source
HGNC:HGNC:7966
See related
Ensembl:ENSG00000025434 MIM:602423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LXRA; LXR-a; RLD-1
Summary
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in fat (RPKM 25.1), spleen (RPKM 16.7) and 23 other tissues See more
Orthologs

Genomic context

See NR1H3 in Genome Data Viewer
Location:
11p11.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (47248300..47269033)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47269851..47290584)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 pseudogene 26 Neighboring gene damage specific DNA binding protein 2 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene uncharacterized LOC101928943 Neighboring gene MAP kinase activating death domain Neighboring gene myosin binding protein C, cardiac

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
NHGRI GWA Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA activates NR1H3 signaling in primary hepatocytes PubMed
gag HIV-1 MA upregulates NR1H3 mRNA expression in HepG2 cells and primary hepatocytes PubMed
gag HIV-1 MA upregulates NR1H3 (LXR-alpha) gene expresssion in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
    Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
  • Liver X Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Liver X Receptor Pathway, organism-specific biosystemThe liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis.
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
  • Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • PPAR Alpha Pathway, organism-specific biosystem (from WikiPathways)
    PPAR Alpha Pathway, organism-specific biosystemPPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc.
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
    SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.
  • VLDL interactions, organism-specific biosystem (from REACTOME)
    VLDL interactions, organism-specific biosystemVery-low-density lipoprotein (VLDL) is a lipoprotein made by the liver (Gibbons et al. 2004) and is one of the five major groups of lipoproteins (chylomicrons, VLDL, LDL, IDL and HDL) that enable fat...
  • VLDLR internalisation and degradation, organism-specific biosystem (from REACTOME)
    VLDLR internalisation and degradation, organism-specific biosystemThe steps involved in proprotein convertase PCSK9-induced degradation of VLDLR are described here (Poirier et al. 2008).

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol binding TAS
Traceable Author Statement
more info
PubMed 
nuclear receptor activity TAS
Traceable Author Statement
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
sterol response element binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cholesterol storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interferon-gamma-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of lipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
negative regulation of pancreatic juice secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of secretion of lysosomal enzymes ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipoprotein lipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
regulation of nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
sterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
oxysterols receptor LXR-alpha
Names
liver X nuclear receptor alpha variant 1
NP_001123573.1
NP_001123574.1
NP_001238863.1
NP_001238864.1
NP_005684.2
XP_005252763.1
XP_005252770.1
XP_005252775.1
XP_011518107.1
XP_011518108.1
XP_011518109.1
XP_011518110.1
XP_016872545.1
XP_016872546.1
XP_024304052.1
XP_024304053.1
XP_024304054.1
XP_024304055.1
XP_024304056.1
XP_024304057.1
XP_024304058.1
XP_024304059.1
XP_024304060.1
XP_024304061.1
XP_024304062.1
XP_024304063.1
XP_024304064.1
XP_024304065.1
XP_024304066.1
XP_024304067.1
XP_024304068.1
XP_024304069.1
XP_024304070.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030392.1 RefSeqGene

    Range
    5001..25734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130101.2NP_001123573.1  oxysterols receptor LXR-alpha isoform 2

    See identical proteins and their annotated locations for NP_001123573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AA644385, AI097478, AU133574, BC008819
    Consensus CDS
    CCDS44584.1
    UniProtKB/Swiss-Prot
    Q13133
    Related
    ENSP00000384745.3, ENST00000405853.7
    Conserved Domains (2) summary
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:210385
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. NM_001130102.2NP_001123574.1  oxysterols receptor LXR-alpha isoform 3

    See identical proteins and their annotated locations for NP_001123574.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks another exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA644385, AI097478, AU135617, BC041172
    Consensus CDS
    CCDS44585.1
    UniProtKB/Swiss-Prot
    Q13133
    Related
    ENSP00000378793.3, ENST00000395397.7
    Conserved Domains (2) summary
    cd06954
    Location:165400
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  3. NM_001251934.1NP_001238863.1  oxysterols receptor LXR-alpha isoform 4

    See identical proteins and their annotated locations for NP_001238863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform.
    Source sequence(s)
    AA644385, AI097478, AK302132, AK311590
    Consensus CDS
    CCDS73285.1
    UniProtKB/TrEMBL
    B4DXU5
    Conserved Domains (2) summary
    cd06954
    Location:216451
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:84184
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  4. NM_001251935.1NP_001238864.1  oxysterols receptor LXR-alpha isoform 4

    See identical proteins and their annotated locations for NP_001238864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform (4).
    Source sequence(s)
    AA644385, AI097478, AK302132, AK311590
    Consensus CDS
    CCDS73285.1
    UniProtKB/TrEMBL
    B4DXU5
    Related
    ENSP00000477707.1, ENST00000616973.4
    Conserved Domains (2) summary
    cd06954
    Location:216451
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:84184
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  5. NM_001363595.1NP_001350524.1  oxysterols receptor LXR-alpha isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC018410
    Consensus CDS
    CCDS86200.1
    Conserved Domains (2) summary
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:165340
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  6. NM_005693.4NP_005684.2  oxysterols receptor LXR-alpha isoform 1

    See identical proteins and their annotated locations for NP_005684.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AA644385, AI097478, AK290614, AK302132
    Consensus CDS
    CCDS7929.1
    UniProtKB/Swiss-Prot
    Q13133
    UniProtKB/TrEMBL
    B4DXU5, F1D8N1
    Related
    ENSP00000387946.2, ENST00000441012.7
    Conserved Domains (2) summary
    cd06954
    Location:210445
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    47248300..47269033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448299.1XP_024304067.1  oxysterols receptor LXR-alpha isoform X4

    Conserved Domains (1) summary
    cd06954
    Location:76375
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  2. XM_005252718.3XP_005252775.1  oxysterols receptor LXR-alpha isoform X13

    Conserved Domains (1) summary
    cl11397
    Location:76251
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. XM_024448292.1XP_024304060.1  oxysterols receptor LXR-alpha isoform X3

    Related
    ENSP00000433271.1, ENST00000481889.6
    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  4. XM_024448302.1XP_024304070.1  oxysterols receptor LXR-alpha isoform X12

    Conserved Domains (1) summary
    cd06954
    Location:1297
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  5. XM_024448288.1XP_024304056.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  6. XM_011519808.2XP_011518110.1  oxysterols receptor LXR-alpha isoform X14

    Conserved Domains (1) summary
    cd06954
    Location:1233
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  7. XM_005252713.3XP_005252770.1  oxysterols receptor LXR-alpha isoform X11

    See identical proteins and their annotated locations for XP_005252770.1

    UniProtKB/Swiss-Prot
    Q13133
    Related
    ENSP00000385801.1, ENST00000407404.5
    Conserved Domains (2) summary
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:210385
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  8. XM_024448294.1XP_024304062.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  9. XM_011519805.2XP_011518107.1  oxysterols receptor LXR-alpha isoform X5

    See identical proteins and their annotated locations for XP_011518107.1

    UniProtKB/Swiss-Prot
    Q13133
    UniProtKB/TrEMBL
    F1D8N1
    Conserved Domains (2) summary
    cd06954
    Location:210445
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  10. XM_024448298.1XP_024304066.1  oxysterols receptor LXR-alpha isoform X2

    Conserved Domains (2) summary
    cd06954
    Location:165400
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  11. XM_024448287.1XP_024304055.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  12. XM_005252706.1XP_005252763.1  oxysterols receptor LXR-alpha isoform X5

    See identical proteins and their annotated locations for XP_005252763.1

    UniProtKB/Swiss-Prot
    Q13133
    UniProtKB/TrEMBL
    F1D8N1
    Conserved Domains (2) summary
    cd06954
    Location:210445
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  13. XM_024448295.1XP_024304063.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  14. XM_024448301.1XP_024304069.1  oxysterols receptor LXR-alpha isoform X7

    Related
    ENSP00000385073.1, ENST00000405576.5
    Conserved Domains (2) summary
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:165340
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  15. XM_024448284.1XP_024304052.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  16. XM_024448291.1XP_024304059.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  17. XM_024448300.1XP_024304068.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  18. XM_024448285.1XP_024304053.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  19. XM_024448286.1XP_024304054.1  oxysterols receptor LXR-alpha isoform X1

    Conserved Domains (2) summary
    cd06954
    Location:210509
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:78178
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  20. XM_024448290.1XP_024304058.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  21. XM_024448297.1XP_024304065.1  oxysterols receptor LXR-alpha isoform X6

    Conserved Domains (1) summary
    cd06954
    Location:121420
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  22. XM_024448296.1XP_024304064.1  oxysterols receptor LXR-alpha isoform X4

    Conserved Domains (1) summary
    cd06954
    Location:76375
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  23. XM_011519807.1XP_011518109.1  oxysterols receptor LXR-alpha isoform X10

    See identical proteins and their annotated locations for XP_011518109.1

    Conserved Domains (1) summary
    cd06954
    Location:76311
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
  24. XM_024448289.1XP_024304057.1  oxysterols receptor LXR-alpha isoform X2

    Conserved Domains (2) summary
    cd06954
    Location:165400
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
  25. XM_011519806.1XP_011518108.1  oxysterols receptor LXR-alpha isoform X7

    UniProtKB/TrEMBL
    B5MBY7
    Conserved Domains (2) summary
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    cl11397
    Location:165340
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  26. XM_017017056.1XP_016872545.1  oxysterols receptor LXR-alpha isoform X8

  27. XM_017017057.1XP_016872546.1  oxysterols receptor LXR-alpha isoform X9

  28. XM_024448293.1XP_024304061.1  oxysterols receptor LXR-alpha isoform X3

    Conserved Domains (2) summary
    cd06954
    Location:165464
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:33133
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
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