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SH2D3A SH2 domain containing 3A [ Homo sapiens (human) ]

Gene ID: 10045, updated on 11-Jun-2021

Summary

Official Symbol
SH2D3Aprovided by HGNC
Official Full Name
SH2 domain containing 3Aprovided by HGNC
Primary source
HGNC:HGNC:16885
See related
Ensembl:ENSG00000125731 MIM:604721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSP1
Expression
Broad expression in stomach (RPKM 5.1), colon (RPKM 4.9) and 20 other tissues See more
Orthologs
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Genomic context

See SH2D3A in Genome Data Viewer
Location:
19p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6752160..6767513, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6752171..6767446, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985302 Neighboring gene G protein-coupled receptor 108 Neighboring gene microRNA 6791 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene Sharpr-MPRA regulatory region 13171 Neighboring gene uncharacterized LOC105372256 Neighboring gene adhesion G protein-coupled receptor E1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in JNK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH2 domain-containing protein 3A
Names
novel SH2-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386583.1NP_001373512.1  SH2 domain-containing protein 3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760, AC020954
    Conserved Domains (2) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:230381
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  2. NM_001386584.1NP_001373513.1  SH2 domain-containing protein 3A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008760, AC020954
    Conserved Domains (2) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:308457
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  3. NM_001386585.1NP_001373514.1  SH2 domain-containing protein 3A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008760, AC020954
    Conserved Domains (2) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:308457
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  4. NM_001386586.1NP_001373515.1  SH2 domain-containing protein 3A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008760, AC020954
    Conserved Domains (2) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:265338
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  5. NM_001386587.1NP_001373516.1  SH2 domain-containing protein 3A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008760, AC020954
    Conserved Domains (2) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:264415
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  6. NM_001386588.1NP_001373517.1  SH2 domain-containing protein 3A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008760, AC020954
    Conserved Domains (1) summary
    cl02485
    Location:187336
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  7. NM_001386589.1NP_001373518.1  SH2 domain-containing protein 3A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008760, AC020954
    Conserved Domains (1) summary
    cl02485
    Location:110261
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  8. NM_005490.3NP_005481.2  SH2 domain-containing protein 3A isoform 1

    See identical proteins and their annotated locations for NP_005481.2

    Status: VALIDATED

    Source sequence(s)
    BC006281
    Consensus CDS
    CCDS12173.1
    UniProtKB/Swiss-Prot
    Q9BRG2
    UniProtKB/TrEMBL
    A8K2M8
    Related
    ENSP00000245908.5, ENST00000245908.11
    Conserved Domains (2) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:309458
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6752160..6767513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527609.2XP_011525911.1  SH2 domain-containing protein 3A isoform X2

    See identical proteins and their annotated locations for XP_011525911.1

    Conserved Domains (2) summary
    cl02485
    Location:214392
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl15255
    Location:148
    SH2; Src homology 2 (SH2) domain
  2. XM_006722602.1XP_006722665.1  SH2 domain-containing protein 3A isoform X3

    Conserved Domains (1) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
  3. XM_005259467.1XP_005259524.1  SH2 domain-containing protein 3A isoform X1

    Conserved Domains (2) summary
    cd10337
    Location:8143
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:309487
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  4. XM_005259472.2XP_005259529.1  SH2 domain-containing protein 3A isoform X4

    See identical proteins and their annotated locations for XP_005259529.1

    UniProtKB/Swiss-Prot
    Q9BRG2
    Related
    ENSP00000393303.2, ENST00000437152.7
    Conserved Domains (1) summary
    cl02485
    Location:187365
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  5. XM_011527608.2XP_011525910.1  SH2 domain-containing protein 3A isoform X2

    See identical proteins and their annotated locations for XP_011525910.1

    Conserved Domains (2) summary
    cl02485
    Location:214392
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl15255
    Location:148
    SH2; Src homology 2 (SH2) domain
  6. XM_017026124.1XP_016881613.1  SH2 domain-containing protein 3A isoform X6

  7. XM_017026123.1XP_016881612.1  SH2 domain-containing protein 3A isoform X5

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