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CRK CRK proto-oncogene, adaptor protein [ Equus caballus (horse) ]

Gene ID: 100072356, updated on 17-Aug-2024

Summary

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Official Symbol
CRKprovided by VGNC
Official Full Name
CRK proto-oncogene, adaptor proteinprovided by VGNC
Primary source
VGNC:VGNC:51791
See related
Ensembl:ENSECAG00000011550
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 11 NC_009154.3 (45462018..45490682, complement)

Chromosome 11 - NC_009154.3Genomic Context describing neighboring genes Neighboring gene double C2 domain beta Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene myosin IC Neighboring gene inositol polyphosphate-5-phosphatase K

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009154.3 Chromosome 11 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adapter molecule crk

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009154.3 Reference EquCab3.0 Primary Assembly

    Range
    45462018..45490682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023653198.1 → XP_023508966.1  adapter molecule crk isoform X3

    UniProtKB/TrEMBL
    A0A9L0TFG8, A0A9L0TMS6
    Related
    ENSECAP00000085323.1, ENSECAT00000094283.1
    Conserved Domains (2) summary
    cd09926
    Location:5 → 122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135 → 189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

  2. XM_023653197.1 → XP_023508965.1  adapter molecule crk isoform X2

    Conserved Domains (3) summary
    cd09926
    Location:5 → 122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135 → 189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cl17036
    Location:237 → 260
    SH3; Src Homology 3 domain superfamily

  3. XM_023653196.1 → XP_023508964.1  adapter molecule crk isoform X1

    UniProtKB/TrEMBL
    F7BME5
    Related
    ENSECAP00000009410.2, ENSECAT00000011976.3
    Conserved Domains (3) summary
    cd09926
    Location:5 → 122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135 → 189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237 → 293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

  4. XM_023653199.1 → XP_023508967.1  adapter molecule crk isoform X4

    UniProtKB/TrEMBL
    A0A9L0TMS6
    Conserved Domains (2) summary
    cd09926
    Location:5 → 122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135 → 189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
Nucleotide Protein
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