2QTF,3KXI


Conserved Protein Domain Family
HflX

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cd01878: HflX 
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HflX GTPase family
HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.
Statistics
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PSSM-Id: 206666
Aligned: 122 rows
Threshold Bit Score: 187.667
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:3KXI: Sulfolobus solfataricus HflX family GTP binding protein (SsGBP); contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                       # ####                        
2QTF_A    139 TYGVEStIKFYKRRINKLMKELESIKIFKEKSIEsnkrnNIPSIGIVGYTNSGKTSLFNSLTglt--------------- 203 Sulfolobus solfata...
3KXI_A    139 TYGVEStIKFYKRRINKLMKELESIKIFKEKSIEsnkrnNIPSIGIVGYTNSGKTSLFNSLTglt--------------- 203 Sulfolobus solfata...
14590961  148 EYQVHQyLKHIKYRMGRIKGELEKIRAEREIRRKkreeeGFVLIALAGYTNAGKSTLLNALTged--------------- 212 Pyrococcus horikos...
14601780  143 MYAADQyLRHLRRRLVKIRRELDKMRSTRESRLSsraksGLKQVSIVGYASAGKTSLFNLLTged--------------- 207 Aeropyrum pernix K1
15669313  142 DYEVEKyYQKVKREIATIKRKLEKLREHRRVARKgr--aKFDTVGLIGYTNAGKTSLLNALTgen--------------- 204 Methanocaldococcus...
NP_281169 150 ERPAAQlKADYRQRITDRRAELDRLDDADDGLREarresGFDLVALAGYTNAGKSTLLRRLAddlavdendg-hgdrtdt 228 Halobacterium sp. ...
16554491  152 EYDESR-EQDIKARISRIRDELSNIEKTEQQRREtrresGFDLVALAGYTNAGKSTLLRRLAadvavdenddrhpdldtt 230 Halobacterium sp. ...
18312175  145 EYVIDAyYRHMVRRISTIRRKLEEIKRGRAMHIMkrkekGVPEVVLTGYTSAGKTTLFNSLVnen--------------- 209 Pyrobaculum aeroph...
20092422   87 DYEDAY-EQDLKKRISRIENELESAEKDDESLRAfrhrkGFSLVSFAGYTNAGKSTLFNAIVdes--------------- 150 Methanosarcina ace...
BAD86165  145 EYQTQQyLKHIRYRMGKIRDELERVKADREVKRKkrenaGFVLVALAGYTNAGKSTLLNALAden--------------- 209 Thermococcus kodak...
Feature 1                                                                                     
2QTF_A    204 qkvDTKLFTTMSPKRYAIPINNR-KIMLVDTVGFIRGIPPQIVDAFFVTLSEAKYSDALILVIDSTFSEnllietlqsSF 282 Sulfolobus solfata...
3KXI_A    204 qkvDTKLFTTMSPKRYAIPINNR-KIMLVDTVGFIRGIPPQIVDAFFVTLSEAKYSDALILVIDSTFSEnllietlqsSF 282 Sulfolobus solfata...
14590961  213 ieaKNQMFTTLDTTTRRFKVKGK-MLLVTDTVGFIDGLPPFIVEAFHSTLEEIVKADIIILVLDASEPWkeirrklfaSL 291 Pyrococcus horikos...
14601780  208 rpvGPEYFTTLQPKHSRITWGGVeGVLAADTVGFIRDVPPEIVEAFHATLAEVKHSDAIVFVIDAAEPPsdieeklhaGI 287 Aeropyrum pernix K1
15669313  205 kesKNQVFTTLTTTTRAIKGIKR-KILVTDTVGFIDDLPPFMIEAFLSTIEESADSDLILIVVDASDDIeeikrklkvNH 283 Methanocaldococcus...
NP_281169 229 aasRDRLFETLNTTTRRATVGER-RVLLTDTVGFVDDLPRWLLSSFRTTLAAAREADAVLLVVDATDDRegir--akvEA 305 Halobacterium sp. ...
16554491  231 aesQDDLFTTLGTTTRRMELARR-DVLLTDTVGFISDLPHWLVESFKSTLESVYQADLVLLVVDASEPLadiqeklatSH 309 Halobacterium sp. ...
18312175  210 klvDGRPFATLETYSRALDLWGK-RIVLTDTIGFIDDLPPLLIESFYSTLQEIIDADRILLVIDGSEPLeeitrkvetSV 288 Pyrobaculum aeroph...
20092422  151 veaQDKLFTTLVPTTRALDLGGR-KALLTDTVGFIEELPHWLVDAFKSTLDEIFLSDLILLVVDVSEKPetilqklstSH 229 Methanosarcina ace...
BAD86165  210 veaKNQMFTTLDTTTRRFRLGTK-RILATDTVGFIDGLPPFIVEAFHSTLEEIVKADIVLLVLDSSEPWgeirrkflaSL 288 Thermococcus kodak...
Feature 1                      ## #                               ###                
2QTF_A    283 EILREIGVSgkPILVTLNKIDkingdlykkldlv-eklskelyspifDVIPISALKrtNLELLRDKIYQLA 352 Sulfolobus solfataricus P2
3KXI_A    283 EILREIGVSgkPILVTLNKIDkingdlykkldlv-eklskelyspifDVIPISALKrtNLELLRDKIYQLA 352 Sulfolobus solfataricus
14590961  292 NVLRELKALdrPMIVALNKVDlisdedakekell-vretidgrantvGVARISAKLn-QLEELYNLIEVAL 360 Pyrococcus horikoshii OT3
14601780  288 DTLARIGALsaPMVIAANKIDalqppeigerial-iereasilphspPVIPISAKTgyGVDRLVRSIIKIV 357 Aeropyrum pernix K1
15669313  284 EILSKINCKa-PIITVFNKVDkitkekkrki-------leeldryivNPIFVSAKYdiNMDLLKEMIIEHL 346 Methanocaldococcus jannasch...
NP_281169 306 SRDELADAEg-TLVPVLNKRDaatdldakr--------rllaehaghAPVVTSATGaeGLDALRERLTDAL 367 Halobacterium sp. NRC-1
16554491  310 DTLYERNEA--PIVTVFNKTDrvedaalaek-------mealaalapAPVAVSARDasNLEELRERIDAAL 371 Halobacterium sp. NRC-1
18312175  289 KTLGEVGIGreRIIPVLNKVDkisvekvrdi-------rrglekyftWFVPVSALTgfGIEALKAVLFLQV 352 Pyrobaculum aerophilum str....
20092422  230 DTLWDRIQGv-PVITVLNKTDlleaseleaa-------meeigymapNPVFVSAKEklGMKELKAEIIKHL 292 Methanosarcina acetivorans C2A
BAD86165  289 QVLRELKALekPIIVALNKIDlieeadaeekvrliwelarergisleDVVKISAREg-RLEELMDALNRVV 358 Thermococcus kodakarensis KOD1

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