2QTF,3KXI


Conserved Protein Domain Family
HflX

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cd01878: HflX 
Click on image for an interactive view with Cn3D
HflX GTPase family
HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.
Statistics
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PSSM-Id: 206666
View PSSM: cd01878
Aligned: 122 rows
Threshold Bit Score: 187.667
Threshold Setting Gi: 15791345
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:3KXI: Sulfolobus solfataricus HflX family GTP binding protein (SsGBP); contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         # ####                        
2QTF_A      139 TYGVEStIKFYKRRINKLMKELESIKIFKEKSIEsnkrnNIPSIGIVGYTNSGKTSLFNSLTglt--------------- 203
3KXI_A      139 TYGVEStIKFYKRRINKLMKELESIKIFKEKSIEsnkrnNIPSIGIVGYTNSGKTSLFNSLTglt--------------- 203
gi 14590961 148 EYQVHQyLKHIKYRMGRIKGELEKIRAEREIRRKkreeeGFVLIALAGYTNAGKSTLLNALTged--------------- 212
gi 14601780 143 MYAADQyLRHLRRRLVKIRRELDKMRSTRESRLSsraksGLKQVSIVGYASAGKTSLFNLLTged--------------- 207
gi 15669313 142 DYEVEKyYQKVKREIATIKRKLEKLREHRRVARKgr--aKFDTVGLIGYTNAGKTSLLNALTgen--------------- 204
gi 15791345 150 ERPAAQlKADYRQRITDRRAELDRLDDADDGLREarresGFDLVALAGYTNAGKSTLLRRLAddlavdendg-hgdrtdt 228
gi 16554491 152 EYDESR-EQDIKARISRIRDELSNIEKTEQQRREtrresGFDLVALAGYTNAGKSTLLRRLAadvavdenddrhpdldtt 230
gi 18312175 145 EYVIDAyYRHMVRRISTIRRKLEEIKRGRAMHIMkrkekGVPEVVLTGYTSAGKTTLFNSLVnen--------------- 209
gi 20092422  87 DYEDAY-EQDLKKRISRIENELESAEKDDESLRAfrhrkGFSLVSFAGYTNAGKSTLFNAIVdes--------------- 150
gi 57160235 145 EYQTQQyLKHIRYRMGKIRDELERVKADREVKRKkrenaGFVLVALAGYTNAGKSTLLNALAden--------------- 209
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2QTF_A      204 qkvDTKLFTTMSPKRYAIPINNR-KIMLVDTVGFIRGIPPQIVDAFFVTLSEAKYSDALILVIDSTFSEnllietlqsSF 282
3KXI_A      204 qkvDTKLFTTMSPKRYAIPINNR-KIMLVDTVGFIRGIPPQIVDAFFVTLSEAKYSDALILVIDSTFSEnllietlqsSF 282
gi 14590961 213 ieaKNQMFTTLDTTTRRFKVKGK-MLLVTDTVGFIDGLPPFIVEAFHSTLEEIVKADIIILVLDASEPWkeirrklfaSL 291
gi 14601780 208 rpvGPEYFTTLQPKHSRITWGGVeGVLAADTVGFIRDVPPEIVEAFHATLAEVKHSDAIVFVIDAAEPPsdieeklhaGI 287
gi 15669313 205 kesKNQVFTTLTTTTRAIKGIKR-KILVTDTVGFIDDLPPFMIEAFLSTIEESADSDLILIVVDASDDIeeikrklkvNH 283
gi 15791345 229 aasRDRLFETLNTTTRRATVGER-RVLLTDTVGFVDDLPRWLLSSFRTTLAAAREADAVLLVVDATDDRegir--akvEA 305
gi 16554491 231 aesQDDLFTTLGTTTRRMELARR-DVLLTDTVGFISDLPHWLVESFKSTLESVYQADLVLLVVDASEPLadiqeklatSH 309
gi 18312175 210 klvDGRPFATLETYSRALDLWGK-RIVLTDTIGFIDDLPPLLIESFYSTLQEIIDADRILLVIDGSEPLeeitrkvetSV 288
gi 20092422 151 veaQDKLFTTLVPTTRALDLGGR-KALLTDTVGFIEELPHWLVDAFKSTLDEIFLSDLILLVVDVSEKPetilqklstSH 229
gi 57160235 210 veaKNQMFTTLDTTTRRFRLGTK-RILATDTVGFIDGLPPFIVEAFHSTLEEIVKADIVLLVLDSSEPWgeirrkflaSL 288
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                        ## #                               ###                
2QTF_A      283 EILREIGVSgkPILVTLNKIDkingdlykkldlv-eklskelyspifDVIPISALKrtNLELLRDKIYQLA 352
3KXI_A      283 EILREIGVSgkPILVTLNKIDkingdlykkldlv-eklskelyspifDVIPISALKrtNLELLRDKIYQLA 352
gi 14590961 292 NVLRELKALdrPMIVALNKVDlisdedakekell-vretidgrantvGVARISAKLn-QLEELYNLIEVAL 360
gi 14601780 288 DTLARIGALsaPMVIAANKIDalqppeigerial-iereasilphspPVIPISAKTgyGVDRLVRSIIKIV 357
gi 15669313 284 EILSKINCKa-PIITVFNKVDkitkekkrki-------leeldryivNPIFVSAKYdiNMDLLKEMIIEHL 346
gi 15791345 306 SRDELADAEg-TLVPVLNKRDaatdldakr--------rllaehaghAPVVTSATGaeGLDALRERLTDAL 367
gi 16554491 310 DTLYERNEA--PIVTVFNKTDrvedaalaek-------mealaalapAPVAVSARDasNLEELRERIDAAL 371
gi 18312175 289 KTLGEVGIGreRIIPVLNKVDkisvekvrdi-------rrglekyftWFVPVSALTgfGIEALKAVLFLQV 352
gi 20092422 230 DTLWDRIQGv-PVITVLNKTDlleaseleaa-------meeigymapNPVFVSAKEklGMKELKAEIIKHL 292
gi 57160235 289 QVLRELKALekPIIVALNKIDlieeadaeekvrliwelarergisleDVVKISAREg-RLEELMDALNRVV 358

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