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    GOSR1 golgi SNAP receptor complex member 1 [ Homo sapiens (human) ]

    Gene ID: 9527, updated on 3-Apr-2024

    Summary

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    Official Symbol
    GOSR1provided by HGNC
    Official Full Name
    golgi SNAP receptor complex member 1provided by HGNC
    Primary source
    HGNC:HGNC:4430
    See related
    Ensembl:ENSG00000108587 MIM:604026; AllianceGenome:HGNC:4430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28
    Summary
    This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.3), kidney (RPKM 5.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (30477408..30527592)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (31422038..31472230)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (28804426..28854610)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11994 Neighboring gene RNA, U6 small nuclear 990, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28705846-28706773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28715045-28715730 Neighboring gene Sharpr-MPRA regulatory region 2970 Neighboring gene carboxypeptidase D Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:28732022-28732693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11999 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:28863435-28863984 Neighboring gene arachidonate 12-lipoxygenase pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:28868427-28868928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:28878036-28878566 Neighboring gene TBC1 domain family member 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases. Li M, et al. Curr Protein Pept Sci, 2023. PMID 36924089
    2. Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Prognosis in Colorectal Cancers. Lee SH, et al. Int J Med Sci, 2017. PMID 28638266, Free PMC Article
    3. Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Worse Prognosis in Cervical Cancers. Cho U, et al. PLoS One, 2016. PMID 27611086, Free PMC Article
    4. Segregation of the Qb-SNAREs GS27 and GS28 into Golgi vesicles regulates intra-Golgi transport. Fusella A, et al. Traffic, 2013 May. PMID 23387339
    5. Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53. Sun NK, et al. Biochem J, 2012 Jun 1. PMID 22397410

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases.
      Title: Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases.
    2. these results indicate that GS28 nuclear predominant expression could serve as a prognostic marker for colorectal cancer (CRC) and may help in identifying aggressive forms of CRC
      Title: Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Prognosis in Colorectal Cancers.
    3. High nuclear expression of GS28 is associated with poor prognosis in early-stage cervical cancer patients. GS28 might be a novel prognostic marker and a potential therapeutic target in cervical cancer treatment.
      Title: Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Worse Prognosis in Cervical Cancers.
    4. Golgi vesicles, presumably with COPI, serve to inhibit intra-Golgi transport by the extraction of GS27 and GS28 from the Golgi cisternae, which blocks the formation of inter-cisternal connections
      Title: Segregation of the Qb-SNAREs GS27 and GS28 into Golgi vesicles regulates intra-Golgi transport.
    5. GS28 may potentiate cells to DNA-damage-induced apoptosis by inhibiting the ubiquitination and degradation of p53.
      Title: Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53.
    6. ORP7 negatively regulates GS28 protein stability via sequestration of GATE-16, and may mediate the effect of 25-OH on GS28 and Golgi function.
      Title: OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability.
    7. Apolipoprotein E, growth factor receptor-bound protein 2, Golgi SNAP receptor complex member 1, and glucosidase, beta, acid may play a neurodegenerative role in stress urinary incontinence development.
      Title: Microarray analysis of differentially expressed genes in vaginal tissues in postmenopausal women. The role of stress urinary incontinence.
    8. Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport.
      Title: GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.
    9. RINT-1 coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE complex comprising syntaxin 18.
      Title: RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inter-Golgi cisterna vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi medial cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in transport vesicle TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    Golgi SNAP receptor complex member 1
    Names
    28 kDa Golgi SNARE protein
    28 kDa cis-Golgi SNARE p28
    Golgi SNARE 28 kDa
    cis-golgi SNARE
    golgi integral membrane protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007024.2 → NP_001007025.1  Golgi SNAP receptor complex member 1 isoform 3

      See identical proteins and their annotated locations for NP_001007025.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional segment in one exon and lacks a small segment in another exon in the 5' region, as compared to variant 1. It uses a downstream AUG start codon, and the encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC011840, AF047438, AK000606, AK074298, BC040072, BC040471, BG654545, CB054624
      Consensus CDS
      CCDS45644.1
      UniProtKB/Swiss-Prot
      O95249
      Related
      ENSP00000462638.1, ENST00000467337.6
      Conserved Domains (1) summary
      cd15864
      Location:95 → 160
      SNARE_GS28; SNARE motif of GS28

    2. NM_001007025.2 → NP_001007026.1  Golgi SNAP receptor complex member 1 isoform 2

      See identical proteins and their annotated locations for NP_001007026.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame small segment of 6 nts in the 5' coding region, as compared to variant 1. The encoded isoform 2 thus lacks internal 2 aa, as compared to isoform 1.
      Source sequence(s)
      AC011840, AK000606, AK074298, BC040072, BC040471, BE785872, CB054624
      Consensus CDS
      CCDS45643.1
      UniProtKB/TrEMBL
      A8K5R6, E9PCW1
      Related
      ENSP00000414441.2, ENST00000451249.7
      Conserved Domains (1) summary
      cd15864
      Location:158 → 223
      SNARE_GS28; SNARE motif of GS28

    3. NM_004871.3 → NP_004862.1  Golgi SNAP receptor complex member 1 isoform 1

      See identical proteins and their annotated locations for NP_004862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011840, AK000606, AK074298, BC040072, BC040471, CB054624
      Consensus CDS
      CCDS11258.1
      UniProtKB/Swiss-Prot
      J3KST5, O75392, O95249
      UniProtKB/TrEMBL
      A8K5R6
      Related
      ENSP00000225724.5, ENST00000225724.9
      Conserved Domains (1) summary
      cd15864
      Location:160 → 225
      SNARE_GS28; SNARE motif of GS28

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      30477408..30527592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258070.6 → XP_005258127.1  Golgi SNAP receptor complex member 1 isoform X1

      UniProtKB/TrEMBL
      A8K5R6
      Conserved Domains (1) summary
      cd15864
      Location:210 → 275
      SNARE_GS28; SNARE motif of GS28

    2. XM_017025374.3 → XP_016880863.1  Golgi SNAP receptor complex member 1 isoform X3

      UniProtKB/TrEMBL
      A8K5R6

    3. XM_005258071.6 → XP_005258128.1  Golgi SNAP receptor complex member 1 isoform X2

      UniProtKB/TrEMBL
      A8K5R6
      Conserved Domains (1) summary
      cd15864
      Location:208 → 273
      SNARE_GS28; SNARE motif of GS28

    4. XM_047437109.1 → XP_047293065.1  Golgi SNAP receptor complex member 1 isoform X4

    5. XM_047437111.1 → XP_047293067.1  Golgi SNAP receptor complex member 1 isoform X7

    6. XM_047437110.1 → XP_047293066.1  Golgi SNAP receptor complex member 1 isoform X7

    7. XM_005258072.4 → XP_005258129.1  Golgi SNAP receptor complex member 1 isoform X7

      See identical proteins and their annotated locations for XP_005258129.1

      UniProtKB/Swiss-Prot
      O95249
      Conserved Domains (1) summary
      cd15864
      Location:95 → 160
      SNARE_GS28; SNARE motif of GS28

    8. XM_017025375.3 → XP_016880864.1  Golgi SNAP receptor complex member 1 isoform X5

      UniProtKB/TrEMBL
      K7EJC8
      Related
      ENSP00000465115.1, ENST00000581721.5

    9. XM_017025376.3 → XP_016880865.1  Golgi SNAP receptor complex member 1 isoform X6

      UniProtKB/TrEMBL
      K7EJC8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      31422038..31472230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317886.1 → XP_054173861.1  Golgi SNAP receptor complex member 1 isoform X7

    2. XM_054317883.1 → XP_054173858.1  Golgi SNAP receptor complex member 1 isoform X5

    3. XM_054317884.1 → XP_054173859.1  Golgi SNAP receptor complex member 1 isoform X6

    4. XM_054317879.1 → XP_054173854.1  Golgi SNAP receptor complex member 1 isoform X1

    5. XM_054317880.1 → XP_054173855.1  Golgi SNAP receptor complex member 1 isoform X2

    6. XM_054317881.1 → XP_054173856.1  Golgi SNAP receptor complex member 1 isoform X3

    7. XM_054317887.1 → XP_054173862.1  Golgi SNAP receptor complex member 1 isoform X7

    8. XM_054317885.1 → XP_054173860.1  Golgi SNAP receptor complex member 1 isoform X7

    9. XM_054317882.1 → XP_054173857.1  Golgi SNAP receptor complex member 1 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95249.1 GenPept UniProtKB/Swiss-Prot:O95249

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