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Gosr1 golgi SNAP receptor complex member 1 [ Mus musculus (house mouse) ]

Gene ID: 53334, updated on 9-May-2024

Summary

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Official Symbol
Gosr1provided by MGI
Official Full Name
golgi SNAP receptor complex member 1provided by MGI
Primary source
MGI:MGI:1858260
See related
Ensembl:ENSMUSG00000010392 AllianceGenome:MGI:1858260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GS28; GOSRI; GOS-28
Summary
Predicted to enable SNAP receptor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde transport, endosome to Golgi; and vesicle fusion. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Located in Golgi membrane. Orthologous to human GOSR1 (golgi SNAP receptor complex member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 9.6), placenta adult (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gosr1 in Genome Data Viewer
Location:
11 B5; 11 46.02 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76617428..76654404, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76726602..76763578, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix family, member a9 Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene STARR-positive B cell enhancer ABC_E9829 Neighboring gene STARR-positive B cell enhancer ABC_E3977 Neighboring gene carboxypeptidase D Neighboring gene STARR-seq mESC enhancer starr_30045 Neighboring gene predicted gene, 53688 Neighboring gene predicted gene, 40200

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. Xu Y, et al. J Biol Chem, 1998 Aug 21. PMID 9705316
  2. GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. Sagiv Y, et al. EMBO J, 2000 Apr 3. PMID 10747018, Free PMC Article
  3. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. Zhang T, et al. J Biol Chem, 2001 Jul 20. PMID 11323436
  4. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. Loh E, et al. J Cell Sci, 2005 Mar 15. PMID 15728249
  5. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. Kuliyev E, et al. J Neurosci, 2018 Mar 7. PMID 29437892, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in inter-Golgi cisterna vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in Golgi medial cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
Golgi SNAP receptor complex member 1
Names
28 kDa Golgi SNARE protein
28 kDa cis-Golgi SNARE p28
Cis-Golgi SNARE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356321.1 → NP_001343250.1  Golgi SNAP receptor complex member 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK133836, AK147799, AK161386, BQ032729, CB522161
    UniProtKB/TrEMBL
    Q80UU0
    Conserved Domains (1) summary
    cd15864
    Location:158 → 223
    SNARE_GS28; SNARE motif of GS28

  2. NM_016810.4 → NP_058090.2  Golgi SNAP receptor complex member 1 isoform 1

    See identical proteins and their annotated locations for NP_058090.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK133836, AK147799, AK161386, BQ032729
    Consensus CDS
    CCDS25070.1
    UniProtKB/Swiss-Prot
    O88630, Q91VU9
    UniProtKB/TrEMBL
    Q80UU0
    Related
    ENSMUSP00000010536.9, ENSMUST00000010536.9
    Conserved Domains (1) summary
    cd15864
    Location:160 → 225
    SNARE_GS28; SNARE motif of GS28

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76617428..76654404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88630.2 GenPept UniProtKB/Swiss-Prot:O88630

Gene LinkOut

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