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GOSR1 golgi SNAP receptor complex member 1 [ Homo sapiens (human) ]

Gene ID: 9527, updated on 12-Oct-2019

Summary

Official Symbol
GOSR1provided by HGNC
Official Full Name
golgi SNAP receptor complex member 1provided by HGNC
Primary source
HGNC:HGNC:4430
See related
Ensembl:ENSG00000108587 MIM:604026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28
Summary
This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.3), kidney (RPKM 5.6) and 25 other tissues See more
Orthologs

Genomic context

See GOSR1 in Genome Data Viewer
Location:
17q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (30477402..30527592)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (28804426..28853832)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 990, pseudogene Neighboring gene carboxypeptidase D Neighboring gene arachidonate 12-lipoxygenase pseudogene 1 Neighboring gene TBC1 domain family member 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNAP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
intra-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of vesicle targeting, to, from or within Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi medial cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex TAS
Traceable Author Statement
more info
PubMed 
cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
Golgi SNAP receptor complex member 1
Names
28 kDa Golgi SNARE protein
28 kDa cis-Golgi SNARE p28
Golgi SNARE 28 kDa
cis-golgi SNARE
golgi integral membrane protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007024.2NP_001007025.1  Golgi SNAP receptor complex member 1 isoform 3

    See identical proteins and their annotated locations for NP_001007025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional segment in one exon and lacks a small segment in another exon in the 5' region, as compared to variant 1. It uses a downstream AUG start codon, and the encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC011840, AF047438, AK000606, AK074298, BC040072, BC040471, BG654545, CB054624
    Consensus CDS
    CCDS45644.1
    UniProtKB/Swiss-Prot
    O95249
    Related
    ENSP00000462638.1, ENST00000467337.6
    Conserved Domains (1) summary
    cd15864
    Location:95160
    SNARE_GS28; SNARE motif of GS28
  2. NM_001007025.2NP_001007026.1  Golgi SNAP receptor complex member 1 isoform 2

    See identical proteins and their annotated locations for NP_001007026.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame small segment of 6 nts in the 5' coding region, as compared to variant 1. The encoded isoform 2 thus lacks internal 2 aa, as compared to isoform 1.
    Source sequence(s)
    AC011840, AK000606, AK074298, BC040072, BC040471, BE785872, CB054624
    Consensus CDS
    CCDS45643.1
    UniProtKB/Swiss-Prot
    O95249
    UniProtKB/TrEMBL
    E9PCW1
    Related
    ENSP00000414441.2, ENST00000451249.6
    Conserved Domains (1) summary
    cd15864
    Location:158223
    SNARE_GS28; SNARE motif of GS28
  3. NM_004871.3NP_004862.1  Golgi SNAP receptor complex member 1 isoform 1

    See identical proteins and their annotated locations for NP_004862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011840, AK000606, AK074298, BC040072, BC040471, CB054624
    Consensus CDS
    CCDS11258.1
    UniProtKB/Swiss-Prot
    O95249
    Related
    ENSP00000225724.5, ENST00000225724.9
    Conserved Domains (1) summary
    cd15864
    Location:160225
    SNARE_GS28; SNARE motif of GS28

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    30477402..30527592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258072.3XP_005258129.1  Golgi SNAP receptor complex member 1 isoform X6

    See identical proteins and their annotated locations for XP_005258129.1

    UniProtKB/Swiss-Prot
    O95249
    Conserved Domains (1) summary
    cd15864
    Location:95160
    SNARE_GS28; SNARE motif of GS28
  2. XM_017025375.2XP_016880864.1  Golgi SNAP receptor complex member 1 isoform X4

    Related
    ENSP00000465115.1, ENST00000581721.5
  3. XM_017025376.2XP_016880865.1  Golgi SNAP receptor complex member 1 isoform X5

  4. XM_005258071.5XP_005258128.1  Golgi SNAP receptor complex member 1 isoform X2

    Conserved Domains (1) summary
    cd15864
    Location:208273
    SNARE_GS28; SNARE motif of GS28
  5. XM_017025377.1XP_016880866.1  Golgi SNAP receptor complex member 1 isoform X7

  6. XM_017025374.2XP_016880863.1  Golgi SNAP receptor complex member 1 isoform X3

  7. XM_005258070.5XP_005258127.1  Golgi SNAP receptor complex member 1 isoform X1

    Conserved Domains (1) summary
    cd15864
    Location:210275
    SNARE_GS28; SNARE motif of GS28
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