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SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [ Gallus gallus (chicken) ]

Gene ID: 422808, updated on 6-Jun-2024

Summary

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Symbol
SEPSECSprovided by CGNC
Full Name
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthaseprovided by CGNC
Primary source
CGNC:10707
See related
Ensembl:ENSGALG00010010161
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See SEPSECS in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (73053333..73077162)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (73036039..73059868)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type containing 4 Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene leucine rich repeat LGI family member 2 Neighboring gene uncharacterized LOC121110519

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Priority in selenium homeostasis involves regulation of SepSecS transcription in the chicken brain. Li JL, et al. PLoS One, 2012. PMID 22536434, Free PMC Article
  2. The expression of chicken selenoprotein W, selenocysteine-synthase (SecS), and selenophosphate synthetase-1 (SPS-1) in CHO-K1 cells. Han YH, et al. Biol Trace Elem Res, 2012 Jul. PMID 22311084
  3. Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels. Xu JX, et al. Biol Trace Elem Res, 2016 Apr. PMID 26282526, Free PMC Article
  4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dietary low Se downregulated the mRNA expressions of Gpx1-4, Txnrd3, Sepn1, Selw, Sepx1, Selh, and SEPSECS.
    Title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.
  2. chicken SelW could be studied in vitro and that SecS and SPS-1 may have potential roles in SelW biosynthesis.
    Title: The expression of chicken selenoprotein W, selenocysteine-synthase (SecS), and selenophosphate synthetase-1 (SPS-1) in CHO-K1 cells.
  3. Selenium (Se) may regulate SepSecS mRNA stability in the avian brain and SepSecS plays an important role in Se homeostasis regulation.
    Title: Priority in selenium homeostasis involves regulation of SepSecS transcription in the chicken brain.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables O-phosphoseryl-tRNA(Sec) selenium transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in selenocysteine incorporation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
O-phosphoseryl-tRNA(Sec) selenium transferase
NP_001026329.2
XP_015141179.2
XP_046772228.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031158.2 → NP_001026329.2  O-phosphoseryl-tRNA(Sec) selenium transferase

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000074
    UniProtKB/TrEMBL
    F1NHJ1, Q5F3Q6
    Related
    ENSGALP00010013773.1, ENSGALT00010024186.1
    Conserved Domains (1) summary
    TIGR03531
    Location:12 → 458
    selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    73053333..73077162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015285693.4 → XP_015141179.2  O-phosphoseryl-tRNA(Sec) selenium transferase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y5V5, F1NHJ1, Q5F3Q6
    Related
    ENSGALP00010013757.1, ENSGALT00010024157.1
    Conserved Domains (1) summary
    TIGR03531
    Location:2 → 422
    selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    73036039..73059868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046916272.1 → XP_046772228.1  O-phosphoseryl-tRNA(Sec) selenium transferase isoform X1

    UniProtKB/TrEMBL
    F1NHJ1, Q5F3Q6
Nucleotide Protein Strain
Heading Accession and Version

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