3HL2,2Z67


Conserved Protein Domain Family
selenium_SpcS

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TIGR03531: selenium_SpcS 
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O-phosphoseryl-tRNA(Sec) selenium transferase
In the archaea and eukaryotes, the conversion of the mischarged serine to selenocysteine (Sec) on its tRNA is accomplished in two steps. This enzyme, O-phosphoseryl-tRNA(Sec) selenium transferase, acts second, after a phosphophorylation step catalyzed by a homolog of the bacterial SelA protein. [Protein synthesis, tRNA aminoacylation]
Statistics
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PSSM-Id: 211833
Aligned: 12 rows
Threshold Bit Score: 645.949
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3HL2_A        12 LVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLG--NCGVGEREGRVASALVARRHY 89  human
XP_001032036  12 IISKSYIDLSSQALNTRQNLIKVLLSQRCLPDDGWDDLSIEHFLQELAMMDTNNFPN--KMGVGEREGRVFSELVNKRHY 89  Tetrahymena the...
XP_625123     12 LIPSTYVQQGLNAKKARENLIRHFIEHQKWPEEGWDDATIEAFLSDLSQMDSNNFPS--NCSVGEREARIISNIVARRHF 89  honey bee
Q803A7        12 LVSASYVRQGLDARRGHEQLIRRLLDQGKCPEEGWSESTIELFLNELAVMDSNNFLG--NCGVGEREGRVASSLVARRHY 89  zebrafish
Q9HD40        12 LVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLG--NCGVGEREGRVASALVARRHY 89  human
XP_001418795  13 LLSKSYVNQGAQSLRAHDKVFARLLANRRMLGRGLNDVAIEFLVHKLSVMDSNNFID--NVGVGEREGRVFSDMVRRRCY 90  Ostreococcus lu...
Q18953         4 NFGKKEGEYSRLVSKSSNKLLNSLWEKKQIPEEGWSEHTLDLFLSWLSSHDTNNRVDmiPVGAGEREGRVLTPLVQRLHS 83  Caenorhabditis ...
Q58027         8 LIPKHMENRGKLTLKENLKIIENILEQRKAPENGIDEEHIKLLLRLLSFMDTDKDPN--VVQIGEREARVYTKLQRDGVF 85  Methanocaldococ...
Q6LZM9         9 LIPKNMEKRGELVLNEYLKEIEDVFNHRKIPENGIDDEKIKLFLKFLSMMDTDKDPK--SVRIGEREARTYSKIHEELSS 86  Methanococcus m...
Q8TXK0         4 LIPDHMLERGRTVLDSYREPVERLLSERRMPEEGWPDDVIATFLWELSRMDTDKDPK--AARIGEREARVASRLAEESVF 81  Methanopyrus ka...
XP_001455539  12 IIDDKYVKIASNSLNAKEKLFKLLLSQRQLPEEGFDDLTIEYLLNIFATMDTNNFSN--KVGVGERESRIFSALVQKRNY 89  Paramecium tetr...
2Z67_A        29 LIPKNXEKRGELVLNEYLKEIEDVFNHRKIPENGIDDEKIKLFLKFLSXXDTDKDPK--SVRIGEREARTYSKIHEELSS 106 Methanococcus m...
3HL2_A        90 RFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHtV-ANCFVVPMATGMSLTLCFLTLR----------HK 158 human
XP_001032036  90 YMAHGIGRSGDISAEQPKAAGSSLLLKLTEYLVKDTLKICGYQsI-KSVLIVPLATGMALSLVLSSLR----------GN 158 Tetrahymena the...
XP_625123     90 RMGHGIGRSSDLEEVQPKAAGSSLMYKLTNALVLEVIRYMGVKsI-AGCFLSPMATGMSLVLCMLTFK----------QD 158 honey bee
Q803A7        90 RLIHGIGRSGDIAAVQPKAAGSSLLNKITNSVVLDVLKLTGVRsV-SSCFVVPMATGMSLTLCFLTLR----------HR 158 zebrafish
Q9HD40        90 RFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHtV-ANCFVVPMATGMSLTLCFLTLR----------HK 158 human
XP_001418795  91 SMTHGIGRSGDITAEQPKACGSSAAHALAQCMARDALRLAGMRdLgKRALVLPLATGMTLTLVLSSLRlmvrnsadggVD 170 Ostreococcus lu...
Q18953        84 NLTHGIGRSGNLLEIQPKALGSSMLACLSNEFAKHALHLLGLHaV-KSCIVVPLCTGMSLSLCMTSWR----------RR 152 Caenorhabditis ...
Q58027        86 DFCHGVGRSGNLIDPQPKAPGASVMYKLTNKLLESFLKALGLK---VNAIATPVATGMSLALCLSAAR-----------K 151 Methanocaldococ...
Q6LZM9        87 GFCHGIGRSGNLVDPQPKASGASIMYALTNKILESFFKQLGLN---VHAIATPISTGMSISLCLSAAR-----------K 152 Methanococcus m...
Q8TXK0        82 GFCHGVGRSGTLVDPQPKAPGASIMYALTNRLVTDFLRRLGFR-I-EGAFVVPGATGLSIALCLSALG------------ 147 Methanopyrus ka...
XP_001455539  90 YMGHGIGRSGDLIASQPKAAGSSLIAKLTKHLAKDALKLSNYQ-I-NELLLVPVATGMAISLCLLALK----------SL 157 Paramecium tetr...
2Z67_A       107 GFCHGIGRSGNLVDPQPKASGASIXYALTNKILESFFKQLGLN---VHAIATPISTGXSISLCLSAAR-----------K 172 Methanococcus m...
3HL2_A       159 RPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKV-Q-ELGpDCILCIHSTTSCFAPRVPDRLE 236 human
XP_001032036 159 NFKKRYVIWPRIDQKTCLKCIYTSGLEPLVIENIQKEDKLTTNIEEIEKVI-K-EKQ-DEILCVLSTTSCFAPRIPDDIE 235 Tetrahymena the...
XP_625123    159 RPRAKYVLWPRIDQKSSFKSIITAGLEPIVIETKIIGDELKTDMQRLESQM-A-ALG-ESVACVLTTTSCFAPRACDSVD 235 honey bee
Q803A7       159 RPKARYILWPRIDQKSCFKSMVTAGFEPVVIENVLEGDELRTNLEEVERKI-E-EFGaENTLCVHSTTSCFAPRVPDRLE 236 zebrafish
Q9HD40       159 RPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKV-Q-ELGpDCILCIHSTTSCFAPRVPDRLE 236 human
XP_001418795 171 AAAPNVVIWCRLDQKTCVKAATCAGLEIVVIEPVLNGDQLDTNVHAIERAI-E-DVGvDRLVAVVTSTSCFAPRACDDVE 248 Ostreococcus lu...
Q18953       153 RPKAKYVVWLRIDQKSSLKSIYHAGFEPIIVEPIRDRDSLITDVETVNRII-E-QRG-EEILCVMTTTSCFAPRSPDNVE 229 Caenorhabditis ...
Q58027       152 KYNSNVVIYPYAAHKSPIKATSFIGMRMRLVETVLDGDIVKVEVSDIEDAI-RkEINeNNNPVVLSTLTFFPPRKSDDIK 230 Methanocaldococ...
Q6LZM9       153 KYGSNVVIYPYASHKSPIKAVSFVGMNMRLVETVLDGDRVYVPVEDIENAI-KkEIElGNRPCVLSTLTFFPPRNSDDIV 231 Methanococcus m...
Q8TXK0       148 --EGEEVIYPYAAHKSPIKAVRLAGFGMRVVDTEIEGDRIVVDPGDVEEAL-E---RsESPAAVLSTLTFFPPRSSDPLP 221 Methanopyrus ka...
XP_001455539 158 KPQAKYVLWPRIDQKTCLKCIQTANLIPIVIDSVIQDHVVTTNLDMLIQKV-N-EIGpDNIVCVLSTTSCFAPRIPDNIG 235 Paramecium tetr...
2Z67_A       173 KYGSNVVIYPYASHKSPIKAVSFVGXNXRLVETVLDGDRVYVPVEDIENAIkK-EIElGNRPCVLSTLTFFPPRNSDDIV 251 Methanococcus m...
3HL2_A       237 ELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAG--FNDSFIQEISKMYPGRA 314 human
XP_001032036 236 KIAQLCAKYNIGHVVNNAYGLQCTKIANSVNMGIKNGRVDCLISSTDKNLMVPVGGAFIYS--HSEKVIQEINQLYPGRA 313 Tetrahymena the...
XP_625123    236 SIAALCTQYNIPHLINNAYGLQSTRCMHLIQEASRKGRVDAFVQSTDKNFLVPVGGAIIGS--FDKNLLDRISKMYPGRA 313 honey bee
Q803A7       237 ELSVLCAKHDIPHIVNNAYGVQPSKCMHLIQQGARVGRIDAFVQSLDKNFVVPVGGAIIAG--FDENFIQEISKIYPGRA 314 zebrafish
Q9HD40       237 ELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAG--FNDSFIQEISKMYPGRA 314 human
XP_001418795 249 TVAKLCEKKNVAHVINNAYGVQSRVLCERVSKAWTVGRVDAVVQSTDKNFMVPVGGAVVCCgkRNEALVEAVARNYPGRA 328 Ostreococcus lu...
Q18953       230 AISAICAAHDVPHLVNNAYGLQSEETIRKIAAAHECGRVDAVVQSLDKNFQVPVGGAVIAA--FKQNHIQSIAQSYPGRA 307 Caenorhabditis ...
Q58027       231 EIAKICQDYDIPHIINGAYAIQNFYYIEKLKKALKY-RIDAVVSSSDKNLFTPIGGGIIYT--KDESFLKEISLTYPGRA 307 Methanocaldococ...
Q6LZM9       232 EIAKICENYDIPHIINGAYAIQNNYYLEKLKKAFKY-RVDAVVSSSDKNLLTPIGGGLVYS--TDAEFIKEISLSYPGRA 308 Methanococcus m...
Q8TXK0       222 EIAELCEEYGVPHVVNAAYGIQHEQYRDLLNRAIKRGRVDVVVSSTDKNLLTPVGGGIVYA--PDEETLREVSRAYPGRA 299 Methanopyrus ka...
XP_001455539 236 EIAKICKQFSIYHVVNNAYGLQCNKIANSINLGLAQGTVNLIVSSTDKNFMVPVGGALIYG--NDKKLIKQISELYPGRA 313 Paramecium tetr...
2Z67_A       252 EIAKICENYDIPHIINGAYAIQNNYYLEKLKKAFKY-RVDAVVSSSDKNLLTPIGGGLVYS--TDAEFIKEISLSYPGRA 328 Methanococcus m...
3HL2_A       315 SASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNE-RLLHTPHNPISLAMTLKTLdehR--------- 384 human
XP_001032036 314 SAGPILDVFITLLSMGKKGLKDLLSQRKENLQYLKDCLQKFAERHSE-RLLDIKENTISLALTLTTM---Keqiilekeq 389 Tetrahymena the...
XP_625123    314 SASSIMDVMITLLSLGMAGYKQLITQRKEMYSYLKEELGKLAARHDE-RLLDTKGNPISIGMTLQCL---Shq------- 382 honey bee
Q803A7       315 SASPSLDVLITLLTLGANGYKKLLADRKELYGHLAQELSALAARHGE-RLLKTPHNPISLAMSLNHL---Eah------- 383 zebrafish
Q9HD40       315 SASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNE-RLLHTPHNPISLAMTLKTL---Deh------- 383 human
XP_001418795 329 SASASMDMFITLLSMGEEHWLRLLDEREKLYDYMHAELSKVAEEEGE-RMLRTPGNPISMAMTLSCA---R--------- 395 Ostreococcus lu...
Q18953       308 SSVPSRDLVLTLLYQGQSAFLEPFGKQKQMFLKMRRKLISFAENIGE-CVYEVPENEISSAMTLSTI---P--------- 374 Caenorhabditis ...
Q58027       308 SANPIVNILISLLAIGTKDYLNLMKEQKECKKLLNELLEDLAKKKGE-KVLNV-ENPISSCITTK--------------- 370 Methanocaldococ...
Q6LZM9       309 SATPVVNTLVSLLSMGSKNYLELVKNQKNSKKLLDELLNDLSKKTGG-KFLDV-ESPIASCISVN--------------- 371 Methanococcus m...
Q8TXK0       300 SAAPVAHALISLLSLGMKGYRRLMRRQKECKALLDELLEDLEARRDDvRVLDV-DNPIASAVAVE--------------- 363 Methanopyrus ka...
XP_001455539 314 SAAPILDLFITFLSMGKSGYLQLQKERVENYAYFKEKLQIMTQKISE-QILNTPKNSISIGISLQNL---Kidqn---nq 386 Paramecium tetr...
2Z67_A       329 SATPVVNTLVSLLSXGSKNYLELVKNQKNSKKLLDELLNDLSKKTGG-KFLDV-ESPIASCISVN--------------- 391 Methanococcus m...
3HL2_A       385 --DKAVTQLGSMLFTRQVSGARVVPLGSMq-TVSGYTFRGFMSHTNNY-PCAYLNAASAIGMKMQDVDLFIKRLDRCL 458 human
XP_001032036 390 enEKDITSLGGILYSKRVMGSRILSNQTK--SVCGIKFKNYGSHSDSFtYLPYMTIACAIGMEKKEIDQFLLKLEDSF 465 Tetrahymena therm...
XP_625123    383 hdNKQVTMLGLMLFLRNVSGTRVITTTESk-HIVSHKFEGWGAHNSNY-PVPYLTAAAALGMKKSDVDMFIQRLDKAL 458 honey bee
Q803A7       384 -sSSAVTQLGSMLFTRQVSGARVVPLGVQq-TVSGHTFSGFMSHSEAY-PCPYLNAASAIGITKGDVTVCMKRLGKCL 458 zebrafish
Q9HD40       384 -rDKAVTQLGSMLFTRQVSGARVVPLGSMq-TVSGYTFRGFMSHTNNY-PCAYLNAASAIGMKMQDVDLFIKRLDRCL 458 human
XP_001418795 396 --GISPTMFGSMLFSRCVSGTRVVAPGEVk-TVGGIEFHGFGASHSAY-PETYFTAAAAIGTTRADVDRFASVLRKTF 469 Ostreococcus luci...
Q18953       375 --PAKQTLFGSILFAKGITGARVVTSSQSktTIEGCEFINFGSHTTEQ-HGGYLNIACSVGMTDHELEELFTRLTSSY 449 Caenorhabditis el...
Q58027       371 ---KDPLDVAGKLYNLRVTGPRGVRRND---KFGTCYLKEYPYD--------YIVVNSAIGVKKEDIYKVIEKLDEVL 434 Methanocaldococcu...
Q6LZM9       372 ---SDPVEIAAKLYNLRVTGPRGIKKTD---HFGNCYLGTYTHD--------YIVMNAAIGVRTEDIVNSVSKLEKIL 435 Methanococcus mar...
Q8TXK0       364 --GHDPVDLAARLYVRRVTGPRGVRADD---PFGTSRLRGYHSN--------YITINAAIGVREEDVKTAVERLEREL 428 Methanopyrus kand...
XP_001455539 387 eeKNQITKLGAILYSKKVMGSRVITNKKNk-VVCGIEFKNYGSHCDNY-FTPYITVACAIGLTKQEIDTFVQEFEKAY 462 Paramecium tetrau...
2Z67_A       392 ---SDPVEIAAKLYNLRVTGPRGIKKTD---HFGNCYLGTYTHD--------YIVXNAAIGVRTEDIVNSVSKLEKIL 455 Methanococcus mar...
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