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    MCM3 minichromosome maintenance complex component 3 [ Homo sapiens ]

    Gene ID: 4172, updated on 11-May-2012
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    Summary

    Official Symbol
    MCM3provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 3provided by HGNC
    Primary source
    HGNC:6945
    Locus tag
    RP1-108C2.3
    See related
    Ensembl:ENSG00000112118; HPRD:04072; MIM:602693; Vega:OTTHUMG00000014844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCC5; P1.h; RLFB; P1-MCM3; MGC1157
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p12
    Sequence :
    Chromosome: 6; NC_000006.11 (52128812..52149582, complement)
    See MCM3 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene 1 Neighboring gene interleukin 17F Neighboring gene progestin and adipoQ receptor family member VIII Neighboring gene EF-hand domain (C-terminal) containing 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A cohesin-RAD21 interactome. Panigrahi AK, et al. Biochem J, 2012 Mar 15. PMID 22145905.
    2. Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Fedorova OA, et al. Biochem Biophys Res Commun, 2011 Dec 16. PMID 22079093.
    3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    4. Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle. Li J, et al. J Biol Chem, 2011 Nov 18. PMID 21965652.
    5. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.

    See all (90) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. excess of MCM3 up-regulates the phosphorylation of CHK1 Ser-345 and CDK2 Thr-14.
      Title: Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle.
    2. MCM3 gene expression is decreased in follicular variant of papillary thyroid carcinoma, contrary to expectation.
      Title: Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
    3. deregulation of MCM2, MCM3 and MCM7 expression might be involved in medulloblastoma tumorigenesis
      Title: Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion.
    4. Using U373MG cells we found that HCMV IE86 protein was bound to Mcm3, but did not inhibit the cellular DNA synthesis.
      Title: Human cytomegalovirus IE86 protein binds to cellular Mcm3 protein but does not inhibit its binding to the Epstein-Barr virus oriP in U373MG-p220.2 cells.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    6. MCM3 may be a more reliable proliferation marker than Ki-67 in accessing the growth of tumor and evaluating tumor aggressiveness of papillary thyroid carcinoma.
      Title: Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma.
    7. These data reveal that CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 complex.
      Title: Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex.
    8. MCM3 is overexpressed in human astrocytic tumors and elicits a cancer-restricted humoral immune response in some patients with brain neoplasms
      Title: Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma.
    9. analysis of carboxyl-terminal MCM3 phosphorylation sites and their motifs
      Title: Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
    10. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with this protein
      Title: The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3.
    Submit: New GeneRIF Correction See all (14)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002379.2 NP_004517.2 MCM2    BIND  PubMed Mcm2 interacts with Mcm3. 
    NP_002379.2 NP_004517.2 MCM2    BIND  PubMed MCM2 interacts with MCM3. 
    NP_002379.2 NP_006730.2 MCM5    BIND  PubMed Mcm3 interacts with Mcm5. 
    NP_002379.2 NP_006730.2 MCM5    BIND  PubMed MCM3 interacts with MCM5. 
    NP_002379.2 NP_005907.3 MCM7    BIND  PubMed Mcm3 interacts with Mcm7. 
    NP_002379.2 MCM7    BIND  PubMed MCM3 interacts with MCM7. 
    NP_002379.2 NC_001345.1     BIND  PubMed Human MCM3 interacts with Epstein-Barr virus (EBV) OriP. 
    P25205 O75419 CDC45    HPRD  PubMed  
    P25205 Q99459 CDC5L    HPRD  PubMed  
    P25205 Q99741 CDC6    HPRD  PubMed  
    P25205 O00311 CDC7    HPRD  PubMed  
    P25205 P24941 CDK2    HPRD  PubMed  
    P25205 Q9UBU7 DBF4    HPRD  PubMed  
    P25205 Q96CS2 HAUS1    HPRD  PubMed  
    P25205 Q7L590 MCM10    HPRD  PubMed  
    P25205 P49736 MCM2    HPRD  PubMed  
    P25205 O60318 MCM3AP    HPRD  PubMed  
    P25205 P33991 MCM4    HPRD  PubMed  
    P25205 P33992 MCM5    HPRD  PubMed  
    P25205 Q14566 MCM6    HPRD  PubMed  
    P25205 P33993 MCM7    HPRD  PubMed  
    P25205 Q13416 ORC2    HPRD  PubMed  
    P25205 O43929 ORC4    HPRD  PubMed  
    P25205 O43913 ORC5    HPRD  PubMed  
    P25205 P53350 PLK1    HPRD  PubMed  
    P25205 P24928 POLR2A    HPRD  PubMed  
    P25205 P30153 PPP2R1A    HPRD  PubMed  
    P25205 P30154 PPP2R1B    HPRD  PubMed  
    P25205 P43351 RAD52    HPRD  PubMed  
    P25205 P42224 STAT1    HPRD  PubMed  
    P25205 Q9Y5B9 SUPT16H    HPRD  PubMed  
    BioGRID:110340 BioGRID:112251 CCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110340 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110340 BioGRID:113915 CDC45    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:110340 BioGRID:113914 CDC7    BioGRID  PubMed Biochemical Activity 
    BioGRID:110340 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110340 BioGRID:116129 DBF4    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:108343 ENSA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:108348 EPAS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110340 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110340 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110340 BioGRID:117486 L3MBTL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110340 BioGRID:113852 LZTR1    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:110339 MCM2    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:114406 MCM3AP    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110340 BioGRID:110342 MCM5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110340 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Two-hybrid 
    BioGRID:110340 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:128982 MMS22L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:111041 ORC2    BioGRID  PubMed Co-fractionation 
    BioGRID:110340 BioGRID:111042 ORC4    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:111043 ORC5    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:111098 PAK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:111404 PMS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:116440 PNKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:116327 PTP4A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:112038 RPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:110340 BioGRID:114045 SMARCA5    BioGRID  PubMed Co-localization 
    BioGRID:110340 BioGRID:112507 SNCG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:112627 SSRP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110340 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:117444 SYF2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110340 BioGRID:110863 TONSL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:119068 WRAP73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110340 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the MCM3 gene: The MCM3 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
    • Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Assembly of the pre-replicative complex, organism-specific biosystemDNA replication pre-initiation in eukaryotic cells begins with the formation of the pre-replicative complex (pre-RC) during the late M phase and continues in the G1 phase of the mitotic cell cycle, a...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • DNA Replication, organism-specific biosystem (from WikiPathways)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
      DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
    • DNA replication, organism-specific biosystem (from KEGG)
      DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
    • DNA replication, conserved biosystem (from KEGG)
      DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
    • DNA strand elongation, organism-specific biosystem (from REACTOME)
      DNA strand elongation, organism-specific biosystemAccurate and efficient genome duplication requires coordinated processes to replicate two template strands at eucaryotic replication forks. Knowledge of the fundamental reactions involved in replicat...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • M/G1 Transition, organism-specific biosystem (from REACTOME)
      M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
    • MCM complex, organism-specific biosystem (from KEGG)
      MCM complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
    • Unwinding of DNA, organism-specific biosystem (from REACTOME)
      Unwinding of DNA, organism-specific biosystemDNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M ph...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA replication TAS
    Traceable Author Statement
    more info
    		  
    DNA strand elongation involved in DNA replication TAS
    Traceable Author Statement
    more info
    		  
    DNA-dependent DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    M/G1 transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    MCM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    alpha DNA polymerase:primase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    DNA replication licensing factor MCM3
    Names
    DNA replication licensing factor MCM3
    p102
    RLF subunit beta
    hRlf beta subunit
    DNA replication factor MCM3
    cervical cancer proto-oncogene 5
    minichromosome maintenance deficient 3
    replication licensing factor, beta subunit
    MCM3 minichromosome maintenance deficient 3
    DNA polymerase alpha holoenzyme-associated protein P1
    NP_002379.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002388.3 → NP_002379.2  DNA replication licensing factor MCM3

      Status: REVIEWED

      Source sequence(s)
      BC001626, BI463632
      Consensus CDS
      CCDS4940.1
      UniProtKB/Swiss-Prot
      P25205
      Related
      ENSP00000229854, OTTHUMP00000016600, ENST00000229854, OTTHUMT00000040897
      Conserved Domains (2) summary
      smart00350
      Location:109 – 654
      Blast Score: 1892
      MCM; minichromosome maintenance proteins
      cl09099
      Location:396 – 454
      Blast Score: 103
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      52128812..52149582, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      51960041..51980813, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL034343.17 CAB75298.1
      CAD92644.1
    genomic AY621074.1 AAT27321.1
    genomic CH471081.1 EAX04366.1
      EAX04367.1
    genomic HH769478.1 CBX85467.1
    mRNA AK222586.1 BAD96306.1
    mRNA AK299566.1 BAG61508.1
    mRNA AK300754.1 BAG62421.1
    mRNA AK301704.1 BAG63176.1
    mRNA AK312928.1 BAG35772.1
    mRNA AY032603.1 AAK56392.1
    mRNA BC001626.1 AAH01626.1
    mRNA BC003509.1 AAH03509.2
    mRNA BI463632.1 None
    mRNA D38073.1 BAA07267.1
    mRNA X62153.2 CAA44078.2
    other-genetic DQ893654.2 ABM84580.1
    other-genetic DQ895840.2 ABM86766.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25205.3 GenPept UniProtKB/Swiss-Prot:P25205
    Q53HJ4 GenPept UniProtKB/TrEMBL:Q53HJ4
    Q7Z6P5 GenPept UniProtKB/TrEMBL:Q7Z6P5
    Q8NHX6 GenPept UniProtKB/TrEMBL:Q8NHX6
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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      Supplemental Content

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