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Mcm3 minichromosome maintenance complex component 3 [ Mus musculus (house mouse) ]

Gene ID: 17215, updated on 8-Dec-2022

Summary

Official Symbol
Mcm3provided by MGI
Official Full Name
minichromosome maintenance complex component 3provided by MGI
Primary source
MGI:MGI:101845
See related
Ensembl:ENSMUSG00000041859 AllianceGenome:MGI:101845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P1; Mcmd; p1.m; P1-MCM3
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in DNA strand elongation involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication initiation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; limb; myocardium layer; neural ectoderm; and retina. Orthologous to human MCM3 (minichromosome maintenance complex component 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 48.6), liver E14.5 (RPKM 44.8) and 18 other tissues See more
Orthologs
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Genomic context

See Mcm3 in Genome Data Viewer
Location:
1; 1 A4
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (20873188..20890536, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (20802966..20820312, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 17A Neighboring gene interleukin 17F Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene Neighboring gene predicted gene, 24723

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated DNA replication initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
 
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA replication licensing factor MCM3
Names
DNA polymerase alpha holoenzyme-associated protein P1
mini chromosome maintenance deficient
minichromosome maintenance deficient 3
NP_032589.1
XP_030107786.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008563.3NP_032589.1  DNA replication licensing factor MCM3

    See identical proteins and their annotated locations for NP_032589.1

    Status: VALIDATED

    Source sequence(s)
    AC156980, AC159614
    Consensus CDS
    CCDS14843.1
    UniProtKB/Swiss-Prot
    P25206, Q61492
    UniProtKB/TrEMBL
    Q3UI57
    Related
    ENSMUSP00000059192.10, ENSMUST00000053266.11
    Conserved Domains (3) summary
    smart00350
    Location:109654
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:17129
    MCM_N; MCM N-terminal domain
    cl21455
    Location:340479
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    20873188..20890536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251926.2XP_030107786.1  DNA replication licensing factor MCM3 isoform X1

    Conserved Domains (1) summary
    smart00350
    Location:63608
    MCM; minichromosome maintenance proteins