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MCM3 minichromosome maintenance complex component 3 [ Homo sapiens (human) ]

Gene ID: 4172, updated on 13-Mar-2020

Summary

Official Symbol
MCM3provided by HGNC
Official Full Name
minichromosome maintenance complex component 3provided by HGNC
Primary source
HGNC:HGNC:6945
See related
Ensembl:ENSG00000112118 MIM:602693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCC5; P1.h; RLFB; P1-MCM3
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]
Expression
Ubiquitous expression in lymph node (RPKM 33.0), appendix (RPKM 23.5) and 24 other tissues See more
Orthologs

Genomic context

See MCM3 in Genome Data Viewer
Location:
6p12.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (52264015..52284742, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52128812..52149679, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 20 pseudogene 1 Neighboring gene interleukin 17F Neighboring gene progestin and adipoQ receptor family member 8 Neighboring gene VISTA enhancer hs2064 Neighboring gene EF-hand domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev co-localizes with minichromosome maintenance complex component 3 (MCM3) in the cytoplasmic and nucleoplasmic compartments of cells PubMed
Tat tat HIV-1 Tat upregulates the expression of minichromosome maintenance complex component 3 (MCM3) in Jurkat cells PubMed
tat Interaction of HIV-1 Tat with MCM3 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
Vpr vpr HIV-1 Vpr downregulates MCM3 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation TAS
Traceable Author Statement
more info
PubMed 
DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
alpha DNA polymerase:primase complex TAS
Traceable Author Statement
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear chromosome, telomeric region HDA PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM3
Names
DNA polymerase alpha holoenzyme-associated protein P1
DNA replication factor MCM3
MCM3 minichromosome maintenance deficient 3
RLF subunit beta
cervical cancer proto-oncogene 5
hRlf beta subunit
minichromosome maintenance deficient 3
p102
replication licensing factor, beta subunit
NP_001257401.2
NP_001353298.1
NP_001353299.1
NP_001353300.1
NP_001353301.1
NP_001353302.1
NP_001353303.1
NP_001353304.1
NP_002379.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270472.3NP_001257401.2  DNA replication licensing factor MCM3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Consensus CDS
    CCDS75468.1
    Related
    ENSP00000229854.6, ENST00000229854.12
    Conserved Domains (1) summary
    smart00350
    Location:63608
    MCM; minichromosome maintenance proteins
  2. NM_001366369.2NP_001353298.1  DNA replication licensing factor MCM3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Conserved Domains (2) summary
    smart00350
    Location:109654
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:19104
    MCM_N; MCM N-terminal domain
  3. NM_001366370.2NP_001353299.1  DNA replication licensing factor MCM3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Conserved Domains (2) summary
    smart00350
    Location:109671
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:19104
    MCM_N; MCM N-terminal domain
  4. NM_001366371.2NP_001353300.1  DNA replication licensing factor MCM3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Conserved Domains (2) summary
    smart00350
    Location:109637
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:19104
    MCM_N; MCM N-terminal domain
  5. NM_001366372.2NP_001353301.1  DNA replication licensing factor MCM3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Conserved Domains (2) summary
    smart00350
    Location:109637
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:19104
    MCM_N; MCM N-terminal domain
  6. NM_001366373.2NP_001353302.1  DNA replication licensing factor MCM3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Conserved Domains (1) summary
    cl25443
    Location:6481
    MCM_OB; MCM OB domain
  7. NM_001366374.2NP_001353303.1  DNA replication licensing factor MCM3 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Conserved Domains (1) summary
    cl25443
    Location:1451
    MCM_OB; MCM OB domain
  8. NM_001366375.2NP_001353304.1  DNA replication licensing factor MCM3 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Conserved Domains (2) summary
    COG1241
    Location:17165
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
    cl25443
    Location:177373
    MCM_OB; MCM OB domain
  9. NM_002388.6NP_002379.4  DNA replication licensing factor MCM3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL034343
    Consensus CDS
    CCDS4940.2
    Related
    ENSP00000472940.2, ENST00000596288.7
    Conserved Domains (2) summary
    smart00350
    Location:109654
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:19104
    MCM_N; MCM N-terminal domain

RNA

  1. NR_158963.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL034343
  2. NR_158964.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL034343
  3. NR_158965.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL034343
  4. NR_158966.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL034343

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    52264015..52284742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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