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    Tns2 tensin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315326, updated on 2-May-2024

    Summary

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    Official Symbol
    Tns2provided by RGD
    Official Full Name
    tensin 2provided by RGD
    Primary source
    RGD:1310917
    See related
    Ensembl:ENSRNOG00000010588 AllianceGenome:RGD:1310917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tenc1
    Summary
    Predicted to enable identical protein binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; and peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within several processes, including collagen metabolic process; multicellular organismal homeostasis; and response to muscle activity. Predicted to be located in focal adhesion. Orthologous to human TNS2 (tensin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 169.3), Heart (RPKM 103.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q36
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135108401..135126505)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133229746..133247889)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143702623..143720995)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479613 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC134479789 Neighboring gene SPRY domain containing 3 Neighboring gene insulin-like growth factor binding protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characteristic changes in carbohydrate profile in the kidneys of hereditary nephrotic mice (ICGN strain). Tamura K, et al. J Vet Med Sci, 2000 Apr. PMID 10823724
    2. Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. Eom T, et al. J Cell Biol, 2014 Oct 27. PMID 25332164, Free PMC Article
    3. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Moon KD, et al. Biochim Biophys Acta, 2012 Feb. PMID 22019427, Free PMC Article
    4. Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression. Yam JW, et al. Cancer Res, 2006 Sep 1. PMID 16951145
    5. C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy. Koh A, et al. Mol Cell Biol, 2013 Apr. PMID 23401856, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within collagen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organismal-level homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to muscle activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tensin-2
    Names
    tensin like C1 domain containing phosphatase (tensin 2)
    tensin-like C1 domain-containing phosphatase
    NP_001101584.2
    XP_008764087.1
    XP_008764091.2
    XP_017450825.1
    XP_017450826.1
    XP_017450827.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108114.2 → NP_001101584.2  tensin-2

      Status: VALIDATED

      Source sequence(s)
      BF419140, JAXUCZ010000007
      UniProtKB/TrEMBL
      M0R671
      Related
      ENSRNOP00000096207.1, ENSRNOT00000118793.1
      Conserved Domains (6) summary
      cd09927
      Location:1127 → 1240
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:779 → 1143
      PHA03247; large tegument protein UL36; Provisional
      cd00029
      Location:32 → 79
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1264 → 1396
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:297 → 424
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:132 → 290
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135108401..135126505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595336.3 → XP_017450825.1  tensin-2 isoform X1

      UniProtKB/TrEMBL
      F7FBH3, M0R671
      Related
      ENSRNOP00000014033.5

    2. XM_008765869.3 → XP_008764091.2  tensin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEG8, M0R671
      Related
      ENSRNOP00000090796.1
      Conserved Domains (6) summary
      cd09927
      Location:1127 → 1240
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:779 → 1143
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1264 → 1396
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:297 → 424
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cd20887
      Location:30 → 83
      C1_TNS2; protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins
      cl28904
      Location:132 → 290
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_008765865.3 → XP_008764087.1  tensin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AKK0, M0R671
      Related
      ENSRNOP00000094945.1
      Conserved Domains (6) summary
      cd09927
      Location:1104 → 1217
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:166 → 284
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:9 → 56
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1241 → 1373
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:274 → 401
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      pfam15265
      Location:918 → 1092
      FAM196; FAM196 family

    4. XM_017595338.3 → XP_017450827.1  tensin-2 isoform X4

      UniProtKB/TrEMBL
      M0R671

    5. XM_017595337.3 → XP_017450826.1  tensin-2 isoform X4

      UniProtKB/TrEMBL
      M0R671
    Nucleotide Protein Strain
    Heading Accession and Version

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