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Tns2 tensin 2 [ Mus musculus (house mouse) ]

Gene ID: 209039, updated on 12-May-2024

Summary

Official Symbol
Tns2provided by MGI
Official Full Name
tensin 2provided by MGI
Primary source
MGI:MGI:2387586
See related
Ensembl:ENSMUSG00000037003 AllianceGenome:MGI:2387586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nep; nph; Tenc1; C1-ten
Summary
Predicted to enable several functions, including identical protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Acts upstream of or within several processes, including collagen metabolic process; multicellular organismal homeostasis; and response to muscle activity. Predicted to be located in focal adhesion. Is expressed in genitourinary system; hand mesenchyme; hindlimb digit mesenchyme; sensory organ; and skeleton. Used to study Pierson syndrome. Orthologous to human TNS2 (tensin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 60.8), subcutaneous fat pad adult (RPKM 26.0) and 17 other tissues See more
Orthologs
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Genomic context

See Tns2 in Genome Data Viewer
Location:
15 F2; 15 57.29 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102006910..102024836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102098475..102116401)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41405 Neighboring gene STARR-seq mESC enhancer starr_39815 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene predicted gene, 53915 Neighboring gene SPRY domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E482 Neighboring gene insulin-like growth factor binding protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
nephrosis
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Spontaneous (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tensin-2
Names
C1 domain-containing phosphatase and tensin homolog
C1 domain-containing phosphatase and tensin-like protein
tensin-like C1 domain-containing phosphatase
NP_001342565.1
NP_001403134.1
NP_001403135.1
NP_705761.2
XP_006520754.1
XP_006520756.1
XP_030104299.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355636.2NP_001342565.1  tensin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110512
    Consensus CDS
    CCDS88852.1
    UniProtKB/TrEMBL
    A0A2R8VHQ0
    Related
    ENSMUSP00000041087.10, ENSMUST00000046144.10
    Conserved Domains (6) summary
    cd09927
    Location:11341247
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:189307
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:3279
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12711403
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:297424
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:7251123
    Atrophin-1; Atrophin-1 family
  2. NM_001416205.1NP_001403134.1  tensin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110512
    Related
    ENSMUSP00000155830.2, ENSMUST00000228958.2
  3. NM_001416206.1NP_001403135.1  tensin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110512
    Related
    ENSMUSP00000155309.2, ENSMUST00000230474.2
  4. NM_153533.4NP_705761.2  tensin-2 isoform 1

    See identical proteins and their annotated locations for NP_705761.2

    Status: VALIDATED

    Source sequence(s)
    AC110512
    Consensus CDS
    CCDS37224.1
    UniProtKB/Swiss-Prot
    Q3TZ93, Q3UGR8, Q8CGB6, Q8CJ95, Q8R122
    UniProtKB/TrEMBL
    A0A2R8VHQ0
    Related
    ENSMUSP00000129146.2, ENSMUST00000169627.9
    Conserved Domains (6) summary
    cd09927
    Location:11271240
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:189307
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:3279
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12641396
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:297424
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    pfam15265
    Location:9411115
    FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102006910..102024836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248439.1XP_030104299.1  tensin-2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8VHQ0
    Conserved Domains (6) summary
    cd09927
    Location:11351248
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7261124
    PHA03247; large tegument protein UL36; Provisional
    cd00029
    Location:3380
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12721404
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:298425
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:133291
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_006520691.3XP_006520754.1  tensin-2 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHQ0
    Conserved Domains (6) summary
    cd09927
    Location:11341247
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7251123
    PHA03247; large tegument protein UL36; Provisional
    cd00029
    Location:3279
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12711403
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:297424
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:132290
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. XM_006520693.4XP_006520756.1  tensin-2 isoform X4

    UniProtKB/TrEMBL
    A0A2R8VHQ0
    Conserved Domains (6) summary
    cd09927
    Location:11111224
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:7021100
    PHA03247; large tegument protein UL36; Provisional
    cd00029
    Location:956
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12481380
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:274401
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:109267
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily