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TNS2 tensin 2 [ Homo sapiens (human) ]

Gene ID: 23371, updated on 20-Jan-2019

Summary

Official Symbol
TNS2provided by HGNC
Official Full Name
tensin 2provided by HGNC
Primary source
HGNC:HGNC:19737
See related
Ensembl:ENSG00000111077 MIM:607717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1TEN; TENC1; C1-TEN
Summary
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 68.0), ovary (RPKM 31.0) and 23 other tissues See more
Orthologs

Genomic context

See TNS2 in Genome Data Viewer
Location:
12q13.13
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (53046980..53064379)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53440810..53458163)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 8 Neighboring gene KRT18 locus control region Neighboring gene keratin 18 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC283335 Neighboring gene microRNA 6757 Neighboring gene SPRY domain containing 3 Neighboring gene insulin like growth factor binding protein 6 Neighboring gene sterol O-acyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16320, KIAA1075, DKFZp686D13244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
collagen metabolic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tensin-2
Names
C1 domain-containing phosphatase and tensin homolog
tensin like C1 domain containing phosphatase (tensin 2)
tensin-like C1 domain-containing phosphatase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015319.2NP_056134.2  tensin-2 isoform 1

    See identical proteins and their annotated locations for NP_056134.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF518728, BC054099, BX647126
    Consensus CDS
    CCDS8842.1
    UniProtKB/Swiss-Prot
    Q63HR2
    Related
    ENSP00000319756.3, ENST00000314276.7
    Conserved Domains (5) summary
    cd09927
    Location:11461259
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:199319
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:4289
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12831415
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:307434
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  2. NM_170754.2NP_736610.2  tensin-2 isoform 2

    See identical proteins and their annotated locations for NP_736610.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform 2) that is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF518729, BC054099, BX647126
    Consensus CDS
    CCDS8843.1
    UniProtKB/Swiss-Prot
    Q63HR2
    Related
    ENSP00000319684.6, ENST00000314250.10
    Conserved Domains (5) summary
    cd09927
    Location:11361249
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:189309
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:3279
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12731405
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:297424
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  3. NM_198316.1NP_938072.1  tensin-2 isoform 3

    See identical proteins and their annotated locations for NP_938072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a distinct 5' UTR and coding region, compared to variant 1, resulting in the use of a downstream translational start and a protein (isoform 3) that contains a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF417490, BC054099, BX647126
    Consensus CDS
    CCDS8844.1
    UniProtKB/Swiss-Prot
    Q63HR2
    UniProtKB/TrEMBL
    A0A024RB48
    Related
    ENSP00000369232.3, ENST00000379902.7
    Conserved Domains (4) summary
    cd09927
    Location:10121125
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:65185
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:11491281
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173300
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    53046980..53064379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019089.1XP_016874578.1  tensin-2 isoform X4

  2. XM_011538079.1XP_011536381.1  tensin-2 isoform X5

    Conserved Domains (5) summary
    cd09927
    Location:11301243
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:183303
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:2673
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12671399
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:291418
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  3. XM_017019088.1XP_016874577.1  tensin-2 isoform X3

  4. XM_006719302.3XP_006719365.1  tensin-2 isoform X1

    Conserved Domains (5) summary
    cd09927
    Location:11551268
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:199319
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:4289
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12921424
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:307434
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  5. XM_006719303.1XP_006719366.1  tensin-2 isoform X2

    Conserved Domains (5) summary
    cd09927
    Location:11451258
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:189309
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:3279
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:12821414
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:297424
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RNA

  1. XR_001748642.1 RNA Sequence

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