Tekt4 tektin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tekt4provided by RGD
Official Full Name: tektin 4provided by RGD
Primary source: RGD:1308075
See related: Ensembl:ENSRNOG00000018792 AllianceGenome:RGD:1308075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tek4; Tektin4; RGD1308075
Summary: Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Predicted to act upstream of or within regulation of brood size. Predicted to be located in sperm midpiece and sperm principal piece. Predicted to be active in microtubule cytoskeleton and sperm flagellum. Orthologous to human TEKT4 (tektin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 340.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14992284..14997460)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14487760..14492936)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14828642..14833818)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Tektin 4 is not associated with axonemal tubulins but instead associated with Outer Dense Fibers in rodent spermatozoa.
Title: Tektin 4 is located on outer dense fibers, not associated with axonemal tubulins of flagella in rodent spermatozoa.
Tektin4 protein was predominantly localized in the flagella of spermatozoa, suggesting that it might works as a flagellar component requisite for flagellar stability or sperm motility
Title: Molecular cloning of a new member of TEKTIN family, Tektin4, located to the flagella of rat spermatozoa.

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General gene information

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Markers

RH130246 (e-PCR)
- UniSTS:213533

d10mit6 (e-PCR)
- UniSTS:120628

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium movement involved in cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect regulation of brood size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tektin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.