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Tekt4 tektin 4 [ Mus musculus (house mouse) ]

Gene ID: 71840, updated on 23-Mar-2023

Summary

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Official Symbol
Tekt4provided by MGI
Official Full Name
tektin 4provided by MGI
Primary source
MGI:MGI:1919090
See related
Ensembl:ENSMUSG00000024175 AllianceGenome:MGI:1919090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700010L19Rik
Summary
Acts upstream of or within cilium movement involved in cell motility and regulation of brood size. Located in sperm midpiece and sperm principal piece. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human TEKT4 (tektin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 138.3) See more
Orthologs
human all
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Genomic context

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See Tekt4 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25673523..25695576)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25454549..25476602)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tryptase gamma 1 Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617 Neighboring gene somatostatin receptor 5 Neighboring gene predicted gene, 53993 Neighboring gene predicted gene, 33727

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. Roy A, et al. FASEB J, 2007 Apr. PMID 17244819
  2. Tektin 4 is located on outer dense fibers, not associated with axonemal tubulins of flagella in rodent spermatozoa. Iida H, et al. Mol Reprod Dev, 2006 Jul. PMID 16596631
  3. Tektin 3 is required for progressive sperm motility in mice. Roy A, et al. Mol Reprod Dev, 2009 May. PMID 18951373, Free PMC Article
  4. A heat-shock protein 40, DNAJB13, is an axoneme-associated component in mouse spermatozoa. Guan J, et al. Mol Reprod Dev, 2008 Sep. PMID 18247331
  5. SHARPIN negatively associates with TRAF2-mediated NFκB activation. Liang Y. PLoS One, 2011. PMID 21829440, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Tektin 4 is not associated with axonemal tubulins but instead associated with Outer Dense Fibers in rodent spermatozoa.
    Title: Tektin 4 is located on outer dense fibers, not associated with axonemal tubulins of flagella in rodent spermatozoa.
  2. TEKT4 is necessary for the proper coordinated beating of the sperm flagellum and male reproductive physiology
    Title: Absence of tektin 4 causes asthenozoospermia and subfertility in male mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144759, MGC144760

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within cilium movement involved in cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of brood size IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tektin-4
Names
testicular microtubules-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027951.1 → NP_082227.1  tektin-4

    See identical proteins and their annotated locations for NP_082227.1

    Status: PROVISIONAL

    Source sequence(s)
    AY485267
    Consensus CDS
    CCDS28519.1
    UniProtKB/Swiss-Prot
    Q149S1, Q9DAH3
    UniProtKB/TrEMBL
    A0A0R4J051
    Related
    ENSMUSP00000025002.2
    Conserved Domains (1) summary
    pfam03148
    Location:56 → 434
    Tektin; Tektin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25673523..25695576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250057.1 → XP_030105917.1  tektin-4 isoform X2

    Related
    ENSMUST00000234104.2
    Conserved Domains (1) summary
    pfam03148
    Location:1 → 225
    Tektin; Tektin family

  2. XM_006524948.3 → XP_006525011.1  tektin-4 isoform X1

    Conserved Domains (1) summary
    pfam03148
    Location:46 → 305
    Tektin; Tektin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q149S1.2 GenPept UniProtKB/Swiss-Prot:Q149S1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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