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TEKT4 tektin 4 [ Homo sapiens (human) ]

Gene ID: 150483, updated on 2-Nov-2024

Summary

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Official Symbol
TEKT4provided by HGNC
Official Full Name
tektin 4provided by HGNC
Primary source
HGNC:HGNC:31012
See related
Ensembl:ENSG00000163060 AllianceGenome:HGNC:31012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in cilium assembly and flagellated sperm motility. Predicted to act upstream of with a positive effect on regulation of brood size. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

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See TEKT4 in Genome Data Viewer
Location:
2q11.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (94871430..94876823)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95377957..95383351)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95537175..95542568)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 20 family member A8, pseudogene Neighboring gene RNA, U6 small nuclear 1320, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95535972-95536485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:95536999-95537512 Neighboring gene SOWAHC pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:95539413-95540274 Neighboring gene uncharacterized LOC442028 Neighboring gene MT-CO1 pseudogene 48 Neighboring gene MT-CO3 pseudogene 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Expression of TEKT4 protein decreases in the ejaculated spermatozoa of idiopathic asthenozoospermic men]. Wu WB, et al. Zhonghua Nan Ke Xue, 2012 Jun. PMID 22774605
  2. Enriched variations in TEKT4 and breast cancer resistance to paclitaxel. Jiang YZ, et al. Nat Commun, 2014 May 13. PMID 24823476
  3. TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway. Zheng Z, et al. Endocr Pathol, 2018 Dec. PMID 30251060
  4. Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor. Ge LP, et al. Oncogene, 2021 Mar. PMID 33654196
  5. SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Gui M, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191189, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
    Title: Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
  2. Our study revealed that TEKT4 shows important biological implications in papillary thyroid cancer
    Title: TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway.
  3. TEKT4 germline variations in a high cis linkage are biologically relevant, as ectopic expression of variant TEKT4 deregulates microtubule stability, antagonizes paclitaxel-induced stabilizing effect of microtubules and increases paclitaxel resistance.
    Title: Enriched variations in TEKT4 and breast cancer resistance to paclitaxel.
  4. The expression of TEKT4 is significantly decreased in the ejaculated sperm of idiopathic asthenozoospermia patients.
    Title: [Expression of TEKT4 protein decreases in the ejaculated spermatozoa of idiopathic asthenozoospermic men].
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC27019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axonemal microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tektin-4
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286559.2 → NP_001273488.1  tektin-4 isoform 2

    See identical proteins and their annotated locations for NP_001273488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC097374, AK097438
    Related
    ENST00000468063.1
    Conserved Domains (1) summary
    pfam03148
    Location:2 → 241
    Tektin; Tektin family

  2. NM_144705.4 → NP_653306.1  tektin-4 isoform 1

    See identical proteins and their annotated locations for NP_653306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC097374, BC021716, BI832036
    Consensus CDS
    CCDS2005.1
    UniProtKB/Swiss-Prot
    Q8WW24
    UniProtKB/TrEMBL
    A0A384MEB7
    Related
    ENSP00000295201.4, ENST00000295201.5
    Conserved Domains (1) summary
    pfam03148
    Location:44 → 423
    Tektin; Tektin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    94871430..94876823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510670.3 → XP_011508972.1  tektin-4 isoform X1

    Conserved Domains (1) summary
    pfam03148
    Location:44 → 464
    Tektin; Tektin family

  2. XM_005263876.4 → XP_005263933.1  tektin-4 isoform X2

    Conserved Domains (1) summary
    pfam03148
    Location:44 → 312
    Tektin; Tektin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    95377957..95383351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340654.1 → XP_054196629.1  tektin-4 isoform X1

  2. XM_054340655.1 → XP_054196630.1  tektin-4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WW24.1 GenPept UniProtKB/Swiss-Prot:Q8WW24

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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