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    Gpr176 G protein-coupled receptor 176 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117257, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Gpr176provided by RGD
    Official Full Name
    G protein-coupled receptor 176provided by RGD
    Primary source
    RGD:621718
    See related
    Ensembl:ENSRNOG00000005971 AllianceGenome:RGD:621718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr; Gm1012; RBU-15
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and circadian behavior. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human GPR176 (G protein-coupled receptor 176). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 34.0), Uterus (RPKM 32.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (125690750..125791172, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (105236794..105337664, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110042853..110140756, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fibrous sheath interacting protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120101637 Neighboring gene uncharacterized LOC134486139 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a novel putative G protein-coupled receptor from rat aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP messenger pathway. Ishizaka N, et al. Biochim Biophys Acta, 1994 Jun 21. PMID 8018717
    2. cDNA cloning of a putative G protein-coupled receptor from brain. Hata S, et al. Biochim Biophys Acta, 1995 Mar 14. PMID 7893747
    3. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Doi M, et al. Nat Commun, 2016 Feb 17. PMID 26882873, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 176
    Names
    G-protein coupled receptor AGR9
    putative G protein coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270986.1 → NP_001257915.1  probable G-protein coupled receptor 176

      See identical proteins and their annotated locations for NP_001257915.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q63231, Q64017
      UniProtKB/TrEMBL
      A6HPA4
      Related
      ENSRNOP00000007882.3, ENSRNOT00000007882.5
      Conserved Domains (1) summary
      pfam00001
      Location:57 → 318
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      125690750..125791172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283010.1 → XP_063139080.1  probable G-protein coupled receptor 176 isoform X2

    2. XM_017591434.3 → XP_017446923.1  probable G-protein coupled receptor 176 isoform X1

    3. XM_039104132.2 → XP_038960060.1  probable G-protein coupled receptor 176 isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:4 → 34
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 218
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_039104129.2 → XP_038960057.1  probable G-protein coupled receptor 176 isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:4 → 34
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 218
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_063283011.1 → XP_063139081.1  probable G-protein coupled receptor 176 isoform X4

    6. XM_063283013.1 → XP_063139083.1  probable G-protein coupled receptor 176 isoform X4

    7. XM_063283012.1 → XP_063139082.1  probable G-protein coupled receptor 176 isoform X4

    8. XM_039104128.2 → XP_038960056.1  probable G-protein coupled receptor 176 isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:21 → 47
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1 → 276
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64017.2 GenPept UniProtKB/Swiss-Prot:Q64017

    Gene LinkOut

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