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Gpr176 G protein-coupled receptor 176 [ Mus musculus (house mouse) ]

Gene ID: 381413, updated on 12-May-2024

Summary

Official Symbol
Gpr176provided by MGI
Official Full Name
G protein-coupled receptor 176provided by MGI
Primary source
MGI:MGI:2685858
See related
Ensembl:ENSMUSG00000040133 AllianceGenome:MGI:2685858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1012
Summary
Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and circadian behavior. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in brain and genitourinary system. Orthologous to human GPR176 (G protein-coupled receptor 176). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 1.1), CNS E18 (RPKM 1.0) and 21 other tissues See more
Orthologs
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Genomic context

See Gpr176 in Genome Data Viewer
Location:
2 E5; 2 59.4 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118107577..118205022, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118277096..118374549, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene thrombospondin 1 Neighboring gene fibrous sheath-interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_05456 Neighboring gene STARR-positive B cell enhancer ABC_E7849 Neighboring gene STARR-positive B cell enhancer mm9_chr2:118089004-118089305 Neighboring gene STARR-seq mESC enhancer starr_05457 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene STARR-seq mESC enhancer starr_05459 Neighboring gene STARR-positive B cell enhancer ABC_E1594 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E9525 Neighboring gene signal recognition particle 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

General protein information

Preferred Names
G-protein coupled receptor 176
Names
G-protein coupled receptor AGR9
probable G-protein coupled receptor 176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201367.3NP_958755.1  G-protein coupled receptor 176

    See identical proteins and their annotated locations for NP_958755.1

    Status: VALIDATED

    Source sequence(s)
    AL845495, AL929163
    Consensus CDS
    CCDS16575.1
    UniProtKB/Swiss-Prot
    Q80UC4, Q80WT4
    Related
    ENSMUSP00000037586.3, ENSMUST00000039160.3
    Conserved Domains (1) summary
    pfam00001
    Location:57318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118107577..118205022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251820.2XP_030107680.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:434
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1218
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_011239648.3XP_011237950.1  G-protein coupled receptor 176 isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:1642
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1271
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily