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Gpr176 G protein-coupled receptor 176 [ Mus musculus (house mouse) ]

Gene ID: 381413, updated on 26-Sep-2022

Summary

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Official Symbol
Gpr176provided by MGI
Official Full Name
G protein-coupled receptor 176provided by MGI
Primary source
MGI:MGI:2685858
See related
Ensembl:ENSMUSG00000040133 AllianceGenome:MGI:2685858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1012
Summary
Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and circadian behavior. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in brain and genitourinary system. Orthologous to human GPR176 (G protein-coupled receptor 176). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 1.1), CNS E18 (RPKM 1.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr176 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118107577..118205022, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118277096..118374549, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene thrombospondin 1 Neighboring gene fibrous sheath-interacting protein 1 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene signal recognition particle 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176. Wang T, et al. Sci Rep, 2020 Mar 10. PMID 32157140, Free PMC Article
  2. Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity. Yamaguchi Y, et al. Biol Pharm Bull, 2022. PMID 35908898
  3. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Doi M, et al. Nat Commun, 2016 Feb 17. PMID 26882873, Free PMC Article
  4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  5. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
    Title: Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
  2. Gpr176 is an suprachiasmatic nucleus-enriched orphan G-protein-coupled receptors that sets the pace of circadian behavior.
    Title: Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC62396

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled receptor 176
Names
G-protein coupled receptor AGR9
probable G-protein coupled receptor 176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201367.3 → NP_958755.1  G-protein coupled receptor 176

    See identical proteins and their annotated locations for NP_958755.1

    Status: VALIDATED

    Source sequence(s)
    AL845495, AL929163
    Consensus CDS
    CCDS16575.1
    UniProtKB/Swiss-Prot
    Q80UC4, Q80WT4
    Related
    ENSMUSP00000037586.3, ENSMUST00000039160.3
    Conserved Domains (1) summary
    pfam00001
    Location:57 → 318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118107577..118205022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251820.2 → XP_030107680.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:4 → 34
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 218
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_011239648.3 → XP_011237950.1  G-protein coupled receptor 176 isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:16 → 42
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1 → 271
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WT4.1 GenPept UniProtKB/Swiss-Prot:Q80WT4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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