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GPR176 G protein-coupled receptor 176 [ Homo sapiens (human) ]

Gene ID: 11245, updated on 8-Jul-2021

Summary

Official Symbol
GPR176provided by HGNC
Official Full Name
G protein-coupled receptor 176provided by HGNC
Primary source
HGNC:HGNC:32370
See related
Ensembl:ENSG00000166073 MIM:612183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB-954
Summary
Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
Expression
Broad expression in brain (RPKM 2.2), testis (RPKM 1.7) and 22 other tissues See more
Orthologs
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Genomic context

See GPR176 in Genome Data Viewer
Location:
15q14-q15.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (39795049..39920939, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40091209..40212467, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370785 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene uncharacterized LOC105370941 Neighboring gene uncharacterized LOC105370786 Neighboring gene GPR176 divergent transcript Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene H3 histone pseudogene 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in circadian behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein coupled receptor 176
Names
probable G-protein coupled receptor 176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271854.2NP_001258783.1  G-protein coupled receptor 176 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC012377, AC023908
    Consensus CDS
    CCDS61589.1
    UniProtKB/Swiss-Prot
    Q14439
    Related
    ENSP00000299092.3, ENST00000299092.3
    Conserved Domains (1) summary
    pfam00001
    Location:78318
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001271855.2NP_001258784.1  G-protein coupled receptor 176 isoform 3

    See identical proteins and their annotated locations for NP_001258784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC023908
    Consensus CDS
    CCDS61588.1
    UniProtKB/Swiss-Prot
    Q14439
    Related
    ENSP00000439361.1, ENST00000543580.7
    Conserved Domains (1) summary
    pfam00001
    Location:13274
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_007223.3NP_009154.1  G-protein coupled receptor 176 isoform 1

    See identical proteins and their annotated locations for NP_009154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC012377, AC023908
    Consensus CDS
    CCDS10051.1
    UniProtKB/Swiss-Prot
    Q14439
    Related
    ENSP00000453076.1, ENST00000561100.2
    Conserved Domains (1) summary
    pfam00001
    Location:58319
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    39795049..39920939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021878.2XP_016877367.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:114
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_017021874.2XP_016877363.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:114
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_024449835.1XP_024305603.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:114
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_017021875.2XP_016877364.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:114
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_017021876.1XP_016877365.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:114
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_017021877.1XP_016877366.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:114
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_011521168.3XP_011519470.1  G-protein coupled receptor 176 isoform X1

    See identical proteins and their annotated locations for XP_011519470.1

    Conserved Domains (1) summary
    pfam00001
    Location:26287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  8. XM_017021873.2XP_016877362.1  G-protein coupled receptor 176 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:26287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  9. XM_011521167.3XP_011519469.1  G-protein coupled receptor 176 isoform X1

    See identical proteins and their annotated locations for XP_011519469.1

    Conserved Domains (1) summary
    pfam00001
    Location:26287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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