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    Zfp866 zinc finger protein 866 [ Mus musculus (house mouse) ]

    Gene ID: 330788, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp866provided by MGI
    Official Full Name
    zinc finger protein 866provided by MGI
    Primary source
    MGI:MGI:3584369
    See related
    Ensembl:ENSMUSG00000043090 AllianceGenome:MGI:3584369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830167H18Rik; D330038O06Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; heart; oocyte; sensory organ; and trunk somite. Orthologous to human ZNF670 (zinc finger protein 670) and ZNF844 (zinc finger protein 844). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.4), CNS E14 (RPKM 6.8) and 28 other tissues See more
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    Genomic context

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    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70213974..70227561, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69761324..69774911, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 963 Neighboring gene STARR-positive B cell enhancer ABC_E6642 Neighboring gene STARR-seq mESC enhancer starr_21745 Neighboring gene predicted gene, 19893 Neighboring gene STARR-positive B cell enhancer ABC_E6643 Neighboring gene STARR-positive B cell enhancer ABC_E6644 Neighboring gene ATPase type 13A1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:72332338-72332525 Neighboring gene Gem-interacting protein Neighboring gene predicted gene, 33695

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Potential readthrough

    Included gene: Zfp963

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 866

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177899.3 → NP_808567.2  zinc finger protein 866

      See identical proteins and their annotated locations for NP_808567.2

      Status: VALIDATED

      Source sequence(s)
      AC157564, AK052363, AK137334, CO042014
      Consensus CDS
      CCDS40361.1
      UniProtKB/TrEMBL
      D3Z1K0, Q6PGD2
      Related
      ENSMUSP00000119781.2, ENSMUST00000137573.2
      Conserved Domains (5) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      COG5048
      Location:160 → 503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:456 → 481
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70213974..70227561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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