U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    KAT2B lysine acetyltransferase 2B [ Homo sapiens (human) ]

    Gene ID: 8850, updated on 5-Mar-2024

    Summary

    Official Symbol
    KAT2Bprovided by HGNC
    Official Full Name
    lysine acetyltransferase 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:8638
    See related
    Ensembl:ENSG00000114166 MIM:602303; AllianceGenome:HGNC:8638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAF; PCAF; P/CAF
    Summary
    CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 17.7), bone marrow (RPKM 16.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KAT2B in Genome Data Viewer
    Location:
    3p24.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (20040446..20154404)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (20044513..20158472)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (20081938..20195896)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2C like domain containing 1 Neighboring gene uncharacterized LOC124909352 Neighboring gene SAP18 pseudogene 3 Neighboring gene CRISPRi-validated cis-regulatory element chr3.1018 Neighboring gene ribosomal protein L39 pseudogene 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:20081563-20082533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_67745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19583 Neighboring gene MPRA-validated peak4562 silencer Neighboring gene microRNA 3135a Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14135 Neighboring gene shugoshin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19584 Neighboring gene SGO1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19585 Neighboring gene RNY4 pseudogene 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
    EBI GWAS Catalog
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    EBI GWAS Catalog
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Acetylation of HIV-1 Tat by P/CAF at Lys28 and binding of P/CAF to Lys50 acetylated Tat regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA PubMed
    tat Acetylation of HIV-1 Tat by P/CAF at Lysine 28 enhances Tat binding to CDK9, indicating P/CAF may regulate Tat-mediated transactivation of the HIV-1 LTR PubMed
    tat HIV-1 Tat is acetylated by P/CAF on Lysine 28 PubMed
    tat Small-molecule inhibitors inbihit PCAF bromodomain/Tat-AcK50 protein-peptide interaction, potentially leads for the anti-HIV/AIDS therapeutic strategy PubMed
    tat The K19A, K29R, and K41A mutations decrease HIV-1 Tat binding to PCAF, whereas the K12Q and K12R mutations increase the binding PubMed
    tat HIV-1 Tat recruits P/CAF, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation PubMed
    tat HIV-1 Tat interaction with P/CAF and other histone acetyl transferases is preferentially important for Tat-mediated transactivation of integrated, but not unintegrated, HIV-1 LTR promoter PubMed
    tat HIV-1 Tat forms a ternary complex with p300 and P/CAF PubMed
    tat HIV-1 Tat synergizes with P/CAF to activate the HIV-1 LTR promoter PubMed
    tat Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF PubMed
    tat Binding of HIV-1 Tat to P/CAF inhibits acetylation of p53 on Lysine320 leading to repression of p53-mediated promoter transactivation, suggesting a mechanism whereby Tat may impair tumor suppressor functions and favor neoplasia establishment during AIDS PubMed
    tat The bromodomain (amino acids 712-832) of P/CAF mediates its binding to amino acids 20-40 of non-acetylated HIV-1 Tat, to amino acids 48-57 in the arginine rich motif of Lys50 acetylated Tat, while Lys28 acetylation of Tat abrogates P/CAF binding to Tat PubMed
    tat HIV-1 Tat inhibits the transcriptional activation activity of P/CAF PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables diamine N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K9 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone acetyltransferase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to parathyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in internal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in limb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of centriole replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of rRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling TAS
    Traceable Author Statement
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ATAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in actomyosin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase KAT2B
    Names
    CREBBP-associated factor
    K(lysine) acetyltransferase 2B
    histone acetylase PCAF
    histone acetyltransferase PCAF
    p300/CBP-associated factor
    spermidine acetyltransferase KAT2B
    NP_003875.3
    XP_005265585.1
    XP_047305103.1
    XP_054204252.1
    XP_054204253.1
    XP_054204254.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003884.5NP_003875.3  histone acetyltransferase KAT2B

      See identical proteins and their annotated locations for NP_003875.3

      Status: REVIEWED

      Source sequence(s)
      AC099057
      Consensus CDS
      CCDS2634.1
      UniProtKB/Swiss-Prot
      Q6NSK1, Q92831
      Related
      ENSP00000263754.4, ENST00000263754.5
      Conserved Domains (3) summary
      cd05509
      Location:727826
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:487826
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:75325
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      20040446..20154404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449147.1XP_047305103.1  histone acetyltransferase KAT2B isoform X2

    2. XM_005265528.5XP_005265585.1  histone acetyltransferase KAT2B isoform X1

      Conserved Domains (2) summary
      pfam00583
      Location:550622
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:74325
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      20044513..20158472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348278.1XP_054204253.1  histone acetyltransferase KAT2B isoform X2

    2. XM_054348277.1XP_054204252.1  histone acetyltransferase KAT2B isoform X1

    3. XM_054348279.1XP_054204254.1  histone acetyltransferase KAT2B isoform X2