Kat2b K(lysine) acetyltransferase 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kat2bprovided by MGI
Official Full Name: K(lysine) acetyltransferase 2Bprovided by MGI
Primary source: MGI:MGI:1343094
See related: Ensembl:ENSMUSG00000000708 AllianceGenome:MGI:1343094
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcaf; p/CAF; A930006P13Rik
Summary: Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in internal peptidyl-lysine acetylation and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of gluconeogenesis; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 12.8), bladder adult (RPKM 11.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 27.86 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (53873802..53979749)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (53566774..53672721)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCOA2 coordinates with the transcriptional KAT2B-NF-kappaB partner to trigger inflammation response in acute kidney injury.
Title: NCOA2 coordinates with the transcriptional KAT2B-NF-κB partner to trigger inflammation response in acute kidney injury.
Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice.
Title: Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice.
Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.
Title: Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.
MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12.
Title: MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12.
Study reveals that SIRT6 regulates BMP signaling in a PCAF dependent manner, and that this regulation might extend beyond osteogenic differentiation and have significant implications in undiscovered cellular processes.
Title: SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling.
histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of mesenchymal stem cells.
Title: Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis.
These results uncover p300 as a direct target of mTORC1 and suggest that the mTORC1-p300 pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism
Title: mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
Title: The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy.
Title: Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 and PCAF to the NKX2.5, beta-MHC, Cx43 promoters and attenuated H3K9 hyperacetylation.
Title: Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kat2b (e-PCR), detects polymorphism
- UniSTS:516624

AI461839 (e-PCR)
- UniSTS:181036

Homology

Homologs of the Kat2b gene: The Kat2b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 487 organisms have orthologs with human gene Kat2b
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activity	EXP Inferred from Experiment more info	PubMed
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables diamine N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables histone H3K9 acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IDA Inferred from Direct Assay more info	PubMed
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info
enables peptide-lysine-N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables transcription regulator activator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription regulator activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of gluconeogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in histone H3 acetylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in histone H3 acetylation	ISO Inferred from Sequence Orthology more info
involved_in histone H3 acetylation	NAS Non-traceable Author Statement more info	PubMed
involved_in histone acetylation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within internal peptidyl-lysine acetylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in internal peptidyl-lysine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in internal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromatin binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gluconeogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of histone H3-K9 acetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein acetylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of RNA splicing	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of protein ADP-ribosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
located_in I band	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
located_in actomyosin	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone acetyltransferase KAT2B

Names: histone acetylase PCAF; histone acetyltransferase PCAF; lysine acetyltransferase 2B; p300/CBP-associated factor; spermidine acetyltransferase KAT2B

NP_001177775.1

EC 2.3.1.48

EC 2.3.1.57

NP_064389.2

EC 2.3.1.48

EC 2.3.1.57

XP_006523883.1

EC 2.3.1.48

EC 2.3.1.57

XP_036016288.1

EC 2.3.1.48

EC 2.3.1.57

XP_036016289.1

EC 2.3.1.48

EC 2.3.1.57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190846.1 → NP_001177775.1 histone acetyltransferase KAT2B isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC140263, AK030070

Conserved Domains (4) summary

cd05509
Location:630 → 729

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:390 → 729

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:453 → 525

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:8 → 229

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
NM_020005.4 → NP_064389.2 histone acetyltransferase KAT2B isoform 1

See identical proteins and their annotated locations for NP_064389.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC131785, AC140263, BC082581

Consensus CDS

CCDS28880.1

UniProtKB/Swiss-Prot

Q640M9, Q9JHD1

UniProtKB/TrEMBL

B2RR30

Related

ENSMUSP00000000724.9, ENSMUST00000000724.15

Conserved Domains (4) summary

cd05509
Location:708 → 807

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:468 → 807

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:531 → 603

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:56 → 307

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RNA

NR_151733.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC131785, AC140263

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

53873802..53979749

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523820.5 → XP_006523883.1 histone acetyltransferase KAT2B isoform X1

Conserved Domains (3) summary

cd05509
Location:569 → 668

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:329 → 668

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam06466
Location:1 → 168

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
XM_036160396.1 → XP_036016289.1 histone acetyltransferase KAT2B isoform X3

Conserved Domains (2) summary

COG5076
Location:329 → 440

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam06466
Location:1 → 168

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
XM_036160395.1 → XP_036016288.1 histone acetyltransferase KAT2B isoform X2

Conserved Domains (2) summary

COG5076
Location:468 → 579

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam06466
Location:56 → 307

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain