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Kat2b K(lysine) acetyltransferase 2B [ Mus musculus (house mouse) ]

Gene ID: 18519, updated on 12-May-2024

Summary

Official Symbol
Kat2bprovided by MGI
Official Full Name
K(lysine) acetyltransferase 2Bprovided by MGI
Primary source
MGI:MGI:1343094
See related
Ensembl:ENSMUSG00000000708 AllianceGenome:MGI:1343094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcaf; p/CAF; A930006P13Rik
Summary
Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in internal peptidyl-lysine acetylation and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of gluconeogenesis; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 12.8), bladder adult (RPKM 11.9) and 28 other tissues See more
Orthologs
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Genomic context

See Kat2b in Genome Data Viewer
Location:
17 C; 17 27.86 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (53873802..53979749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (53566774..53672721)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42830 Neighboring gene tumor protein, translationally-controlled, pseudogene 7 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42833 Neighboring gene STARR-seq mESC enhancer starr_42835 Neighboring gene STARR-seq mESC enhancer starr_42837 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42842 Neighboring gene STARR-seq mESC enhancer starr_42845 Neighboring gene STARR-positive B cell enhancer ABC_E8685 Neighboring gene shugoshin 1 Neighboring gene predicted gene, 31532

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diamine N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3K9 acetyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables histone H3K9 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
Inferred from Direct Assay
more info
PubMed 
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
 
enables peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide-lysine-N-acetyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within internal peptidyl-lysine acetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in internal peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein acetylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of protein ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
located_in I band IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in actomyosin IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone acetyltransferase KAT2B
Names
histone acetylase PCAF
histone acetyltransferase PCAF
lysine acetyltransferase 2B
p300/CBP-associated factor
spermidine acetyltransferase KAT2B
NP_001177775.1
NP_064389.2
XP_006523883.1
XP_036016288.1
XP_036016289.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190846.1NP_001177775.1  histone acetyltransferase KAT2B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC140263, AK030070
    Conserved Domains (4) summary
    cd05509
    Location:630729
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:390729
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:453525
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:8229
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
  2. NM_020005.5NP_064389.2  histone acetyltransferase KAT2B isoform 1

    See identical proteins and their annotated locations for NP_064389.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131785, AC140263
    Consensus CDS
    CCDS28880.1
    UniProtKB/Swiss-Prot
    Q3U142, Q640M9, Q9JHD1
    UniProtKB/TrEMBL
    B2RR30
    Related
    ENSMUSP00000000724.9, ENSMUST00000000724.15
    Conserved Domains (4) summary
    cd05509
    Location:708807
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:468807
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:531603
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:56307
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RNA

  1. NR_151733.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131785, AC140263

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    53873802..53979749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523820.5XP_006523883.1  histone acetyltransferase KAT2B isoform X1

    Conserved Domains (3) summary
    cd05509
    Location:569668
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:329668
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:1168
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
  2. XM_036160396.1XP_036016289.1  histone acetyltransferase KAT2B isoform X3

    Conserved Domains (2) summary
    COG5076
    Location:329440
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:1168
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
  3. XM_036160395.1XP_036016288.1  histone acetyltransferase KAT2B isoform X2

    Conserved Domains (2) summary
    COG5076
    Location:468579
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:56307
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RNA

  1. XR_001782056.3 RNA Sequence